2. Anti-infection
  3. HIV
  4. TNK-651

TNK-651 是一种非核苷类 HIV-1 逆转录酶抑制剂。TNK-651 对 HIV-1 SF33 株和非核苷类逆转录酶抑制剂 (NNRTI) 耐药的 HIV-1 A17 株均表现出抑制作用。TNK-651 可用于 HIV-1 感染研究。

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TNK-651

TNK-651 Chemical Structure

CAS No. : 175739-42-1

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TNK-651 相关抗体

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HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TNK-651 is a non-nucleoside HIV-1 reverse transcriptase inhibitor. TNK-651 exhibits inhibitory effects on both the HIV-1 SF33 strain and the NNRTI-resistant HIV-1 A17 strain. TNK-651 can be used for the study of HIV-1 infection[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CEM-SS CC50
> 20 μM
Compound: 3, TNK-651
Cytotoxicity in human CEM-SS cells after 6 days by MTS assay
Cytotoxicity in human CEM-SS cells after 6 days by MTS assay
[PMID: 21499541]
CEM-SS EC50
0.013 μM
Compound: 3, TNK-651
Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by MTS assay
Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by MTS assay
[PMID: 21499541]
MT4 CC50
84.596 μM
Compound: 2, TNK-651
Cytotoxicity against human MT4 cells after 3 days by XTT assay
Cytotoxicity against human MT4 cells after 3 days by XTT assay
[PMID: 23540737]
MT4 CC50
84.6 μM
Compound: 18, TNK-651
Cytotoxicity against human MT4 cells after 3 days by XTT assay
Cytotoxicity against human MT4 cells after 3 days by XTT assay
[PMID: 22283377]
MT4 EC50
0.022 μM
Compound: 18, TNK-651
Antiviral activity against HIV1 SF33 infected in human MT4 cells assessed as inhibition of viral p24 antigen production after 7 days by ELISA
Antiviral activity against HIV1 SF33 infected in human MT4 cells assessed as inhibition of viral p24 antigen production after 7 days by ELISA
[PMID: 22283377]
MT4 EC50
0.022 μM
Compound: 2, TNK-651
Antiviral activity against Human immunodeficiency virus 1 SF33 infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA
Antiviral activity against Human immunodeficiency virus 1 SF33 infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA
[PMID: 23540737]
MT4 EC50
2.398 μM
Compound: 2, TNK-651
Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 harboring reverse transcriptase K103N mutation infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA
Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 harboring reverse transcriptase K103N mutation infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA
[PMID: 23540737]
MT4 EC50
> 10 μM
Compound: 18, TNK-651
Antiviral activity against NNRTI-resistant HIV1 A17 expressing reverse transcriptase K103N and Y181C mutant infected in human MT4 cells assessed as inhibition of viral p24 antigen production after 7 days by ELISA
Antiviral activity against NNRTI-resistant HIV1 A17 expressing reverse transcriptase K103N and Y181C mutant infected in human MT4 cells assessed as inhibition of viral p24 antigen production after 7 days by ELISA
[PMID: 22283377]
MT4 EC50
> 10 μM
Compound: 2, TNK-651
Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 A17 double mutant infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA
Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 A17 double mutant infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA
[PMID: 23540737]
MT4 EC50
> 10 μM
Compound: 2, TNK-651
Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 harboring reverse transcriptase Y181C mutation infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA
Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 harboring reverse transcriptase Y181C mutation infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA
[PMID: 23540737]
PBMC CC50
> 10 μM
Compound: 4b, ZW-IV-55-1, TNK651
Cytotoxicity against human PBMC
Cytotoxicity against human PBMC
[PMID: 17608468]
TZM CC50
65.812 μM
Compound: 2, TNK-651
Cytotoxicity against human TZM-bl cells
Cytotoxicity against human TZM-bl cells
[PMID: 23540737]
分子量

364.44

Formula

C22H24N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TNK-651 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNK-651175739-42-1TNK651TNK 651HIVHuman immunodeficiency virusHIV-1infectionInhibitorinhibitorinhibit

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产品名称：
TNK-651
目录号：
HY-10893
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