2. Immunology/Inflammation
  3. Interleukin Related PD-1/PD-L1
  4. Tolododekin alfa

Tolododekin alfa 是一种将 IL-12 和 Aluminum Hydroxide (HY-B1521) 锚定结合的药物偶联物。Tolododekin alfa 可促进效应性 CD8+ T 细胞向肿瘤部位募集，增强 γ-干扰素的产生，提升 PD-L1 的表达，并在小鼠肿瘤模型中诱导持续的促炎基因表达。Tolododekin alfa 可用于晚期实体瘤的相关研究。

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Tolododekin alfa

Tolododekin alfa Chemical Structure

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Tolododekin alfa 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tolododekin alfa is a drug conjugate that anchors and combines IL-12 with Aluminum Hydroxide (HY-B1521). Tolododekin alfa promotes the recruitment of effector CD8+ T cells to tumor sites, enhances the production of γ-interferon, upregulates the expression of PD-L1, and induces sustained pro-inflammatory gene expression in mouse tumor models. Tolododekin alfa can be used for research related to advanced solid tumors[1].

反应种属

Human
IC50 & Target[1]

IL-12

 

体内研究
(In Vivo)

Tolododekin alfa 可在小鼠肿瘤内长期滞留数周，且无毒性迹象[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

3595  [NCBI]

Accession

Q99665
靶点

IL12RB2
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tolododekin alfa 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tolododekin alfaANK-101ANK101ANK 101Interleukin RelatedPD-1/PD-L1ILPD-1/Programmed death-ligand 1aluminum hydroxideInterleukin 12interferon-γCD8+ T cellsPD-L1murine tumor modelsInhibitorinhibitorinhibit

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目录号：
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