2. Others Membrane Transporter/Ion Channel Cell Cycle/DNA Damage
  3. Drug Derivative GLUT DNA/RNA Synthesis
  4. Triptolide-6-succinate-β-D-glucose

Triptolide-6-succinate-β-D-glucose (Compound 2) 是 Triptolide (HY-32735) 的葡萄糖共轭衍生物。Triptolide-6-succinate-β-D-glucose 是一种靶向葡萄糖转运蛋白 ( GLUT) 的肿瘤选择性前药。Triptolide-6-succinate-β-D-glucose 可诱导 RNA 聚合酶 II (RNA polymerase II) 的 RPB 亚基降解。Triptolide-6-succinate-β-D-glucose 抑制 HEK293T 细胞增殖，其 IC50 值为 268 nM。Triptolide-6-succinate-β-D-glucose 可用于癌症研究，如前列腺癌。

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Triptolide-6-succinate-β-D-glucose

Triptolide-6-succinate-β-D-glucose Chemical Structure

CAS No. : 2003231-25-0

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Triptolide-6-succinate-β-D-glucose 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Triptolide-6-succinate-β-D-glucose (Compound 2) is a glucose-conjugated derivative of Triptolide (HY-32735). Triptolide-6-succinate-β-D-glucose is a tumor-selective prodrug targeting glucose transporters ( GLUT). Triptolide-6-succinate-β-D-glucose can induce the degradation of the RPB subunit of RNA polymerase II. Triptolide-6-succinate-β-D-glucose inhibits the proliferation of HEK293T cells with an IC50 value of 268 nM. Triptolide-6-succinate-β-D-glucose can be used for the research of cancer, such as prostatic cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
2.354 μM
Compound: TG1beta
Cytotoxicity against human HCT-116 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells incubated for 72 hrs by MTT assay
[PMID: 35617856]
HT-29 IC50
2.889 μM
Compound: TG1beta
Cytotoxicity against human HT-29 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells incubated for 72 hrs by MTT assay
[PMID: 35617856]
HUVEC IC50
8.137 μM
Compound: TG1beta
Cytotoxicity against HUVEC incubated for 72 hrs by MTT assay
Cytotoxicity against HUVEC incubated for 72 hrs by MTT assay
[PMID: 35617856]
HaCaT IC50
1.633 μM
Compound: TG1beta
Cytotoxicity against human HaCaT cells incubated for 72 hrs by MTT assay
Cytotoxicity against human HaCaT cells incubated for 72 hrs by MTT assay
[PMID: 35617856]
L02 IC50
1.378 μM
Compound: TG1beta
Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay
[PMID: 35617856]
MDA-MB-231 IC50
2.28 μM
Compound: TG1beta
Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
[PMID: 35617856]
NCI-H1975 IC50
1.859 μM
Compound: TG1beta
Cytotoxicity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
[PMID: 35617856]
NCI-H460 IC50
2.722 μM
Compound: TG1beta
Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay
[PMID: 35617856]
SW-620 IC50
5.512 μM
Compound: TG1beta
Cytotoxicity against human SW-620 cells incubated for 72 hrs by MTT assay
Cytotoxicity against human SW-620 cells incubated for 72 hrs by MTT assay
[PMID: 35617856]
分子量

622.61

Formula

C30H38O14
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Triptolide-6-succinate-β-D-glucose 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Triptolide-6-succinate-β-D-glucose2003231-25-0Drug DerivativeGLUTDNA/RNA SynthesisDrug derivativeGlucose transporterInhibitorinhibitorinhibit

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