2. Anti-infection
  3. Parasite
  4. Trypaflavin bromide

Trypaflavin (bromide) 是一种口服有效的吖啶类化合物，也是一种抗疟 (antimalarial) 剂。Trypaflavin (bromide) 可以侵入生殖细胞。Trypaflavin (bromide) 会诱导未受精卵细胞发生畸变。Trypaflavin (bromide) 会增加染色体畸变的频率。Trypaflavin (bromide) 具有较弱的致突变性。Trypaflavin (bromide) 对利什曼原虫 (Leishmania) 具有高毒性，可导致前鞭毛体立即裂解。

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Trypaflavin bromide

Trypaflavin bromide Chemical Structure

CAS No. : 857613-80-0

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Other Forms of Trypaflavin bromide:

Trypaflavin bromide 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

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生物活性

Trypaflavin (bromide) is an orally active acridine compound and antimalarial agent. Trypaflavin (bromide) invades germ cells. Trypaflavin (bromide) induces aberrations in unfertilized oocytes. Trypaflavin (bromide) increases the frequency of chromosomal aberrations. Trypaflavin (bromide) shows weak mutagenicity. Trypaflavin (bromide) is highly toxic to Leishmania, causing immediate lysis of the leptomonads[1][2].

体内研究
(In Vivo)

Trypaflavin (50 mg/kg; p.o.; single acute dose; day 7 post conception) (bromide) 对妊娠 C3H 小鼠的 F1 代雌性子代诱导显性致死突变，诱导突变频率为 13.25[1]。
Trypaflavin (2 mg/kg/day; p.o.; 50 days) (bromide) 可轻微升高雌性 C3H 小鼠的着床前卵丢失率和死胎植入率，但不会诱发显著的显性致死突变；同时可使雌性 NMRI 小鼠 MII 期卵母细胞的总染色体畸变率小幅升高至 21.1%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H (female; parental generation; pregnant; prenatal in utero treatment to target oogonia/early meiotic oocyte stages); C3H F1 (female; 10 weeks old at mating)[1]
Dosage: 50 mg/kg
Administration: p.o.; single acute dose; day 7, 11, 14, or 15 post conception
Result: Induced significant mutagenic effects only with day 7 post conception treatment: Increased preimplantation egg loss to 24.9%.
Increased dead implants per female to 1.4.
Decreased living embryos per female to 7.2.
Induced dominant lethal mutations of 13.25.
Showed no significant effects with treatment on days 11, 14, or 15 post conception.
Animal Model: C3H (female; 3 weeks old at study start)[1]
Dosage: 2 mg/kg/day
Administration: p.o.; daily; 50 days
Result: Increased preimplantation egg loss to 13.3%.
Increased dead implants per female to 2.2.
Induced dominant lethal mutations of -1.27.
Animal Model: NMRI (female; 3 weeks old at study start)[1]
Dosage: 2 mg/kg/day
Administration: p.o.; daily; at least 50 days
Result: Increased the frequency of aberrant metaphase-II oocytes to 21.1%, aneuploidies to 13.5%, structural aberrations including gaps to 9.3%, and structural aberrations excluding gaps to 8.1%.
Increased yield of all aberration types (aneuploidies, gaps, breaks and fragments, satellite associations, deletions, interchanges).
分子量

304.19

Formula

C14H14BrN3
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Trypaflavin bromide 相关分类

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Keywords:

Trypaflavin857613-80-0 Parasitepregnant miceC3H miceLeishmania tropicaaneuploidiesmetaphase-II oocyte chromosomesmale mouse germ cellsBaghdad boilfibroblastNMRI miceleptomonadsInhibitorinhibitorinhibit

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