2. Cell Cycle/DNA Damage Cytoskeleton Immunology/Inflammation
  3. Microtubule/Tubulin Interleukin Related
  4. Tubulin polymerization-IN-90

Tubulin polymerization-IN-90 是一种微管蛋白 (tubulin) 聚合抑制剂。Tubulin polymerization-IN-90 可通过结合 β-微管蛋白上的诺考达唑结合位点来干扰微管蛋白聚合。Tubulin polymerization-IN-90 可诱导以四次跨膜蛋白 CD63 为标记的细胞外囊泡释放。Tubulin polymerization-IN-90 诱导细胞释放 IL-8。Tubulin polymerization-IN-90 降低癌细胞的活力。Tubulin polymerization-IN-90 可用于急性 T 淋巴细胞白血病等癌症的研究。

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Tubulin polymerization-IN-90

Tubulin polymerization-IN-90 Chemical Structure

CAS No. : 3006800-41-2

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Tubulin polymerization-IN-90 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Tubulin polymerization-IN-90 is a tubulin polymerization inhibitor. Tubulin polymerization-IN-90 disrupts tubulin polymerization by binding to the nocodazole-binding site on β-tubulin. Tubulin polymerization-IN-90 induces the release of extracellular vesicles marked by the tetraspanin CD63. Tubulin polymerization-IN-90 induces the release of IL-8 from cells. Tubulin polymerization-IN-90 reduces the viability of cancer cells. Tubulin polymerization-IN-90 can be used in the research of cancers such as acute T-lymphoblastic leukemia[1].

体外研究
(In Vitro)

Tubulin polymerization-IN-90 (Compound 39) (10 μM; 48 h) 可显著增强 CD63 Tluc-CD9 EmGFP THP-1 细胞中 CD63 细胞外囊泡释放报告基因的活性[1]。
Tubulin polymerization-IN-90 (1-10 μM) 可呈剂量依赖性抑制微管蛋白聚合[1]。
Tubulin polymerization-IN-90 (0.001-0.1 μM；20 h) 可抑制野生型 CEM T 细胞的活力，其 IC50 为 0.09 μM；同时可抑制 CEM-178 TUBB 突变细胞的活力，IC50 为 0.11 μM[1]。
Tubulin polymerization-IN-90 (20 μM) 可诱导人外周血单个核细胞 (hPBMCs) 显著释放人白细胞介素-8 (IL-8)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-90 相关抗体:

Cell Viability Assay[1]

Cell Line: Wild-type CEM T cells, CEM-178 TUBB mutant cells
Concentration: Serially diluted concentrations
Incubation Time: 20 h
Result: Inhibited cell viability with an IC50 of 0.09 μM in wild-type CEM cells and an IC50 of 0.11 μM in CEM-178 mutant cells, showing minimal difference in cytotoxicity between the two cell lines.
分子量

354.43

Formula

C21H14N4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin polymerization-IN-90 相关分类

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Keywords:

Tubulin polymerization-IN-903006800-41-2Microtubule/TubulinInterleukin RelatedILtubulin polymerization inhibitorCEM T cellsacute T-lymphoblastic leukemiaInhibitorinhibitorinhibit

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