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  3. Drug Derivative
  4. U-78517 dihydrochloride

U-78517 dihydrochloride 是 Trolox (HY-101445) 的类似物，是一种强效抗氧化剂。U-78517 dihydrochloride 可抑制 DCVC (HY-19717) 诱导的脂质过氧化，清除 DPPH、氧自由基及氮自由基。U-78517 dihydrochloride 可减轻缺氧条件下离体心肌细胞的损伤。U-78517 dihydrochloride 可用于缺氧损伤、脑缺血及心血管疾病的研究。

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U-78517 dihydrochloride

U-78517 dihydrochloride Chemical Structure

CAS No. : 133681-84-2

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Other Forms of U-78517 dihydrochloride:

U-78517 dihydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

U-78517 dihydrochloride, a Trolox (HY-101445) analog, is a potent antioxidant. U-78517 dihydrochloride inhibits DCVC (HY-19717)-induced lipid peroxidation, scavenges DPPH, oxygen- and nitrogen-based free radicals. U-78517 dihydrochloride attenuates hypoxic injury in iaolated cardiac myocytes. U-78517 dihydrochloride can be used for the research of hypoxic injury, cerebral ischemia, and cardiovascular disease[1][2][3].

体外研究
(In Vitro)

U-78517 (compound U-78517F) (100 µM；0-3 小时) dihydrochloride 完全抑制 DCVC 诱导的脂质过氧化，但未能减轻兔肾皮质切片的细胞损伤[1]。
U-78517F (0.3-3 μM；90 分钟) dihydrochloride 可维持肌膜完整性，减轻缺氧诱导的新生大鼠心肌细胞肌酸激酶和乳酸脱氢酶的释放 (EC50 = 1.7 μM)，但不能防止 ATP 耗竭[2]。
U-78517 (0-0.02 mM) dihydrochloride 以浓度依赖性方式清除超氧阴离子自由基 (IC50 = 6.0 μM)[3]。
U-78517 (0.4-0.8 mM) dihydrochloride 以浓度依赖性方式清除羟基自由基 (IC50 = 600 μM)[3]。
U-78517 (100 μM；1 分钟) dihydrochloride 可直接清除 DPPH 自由基，消除 EPR 信号并改变溶液颜色[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

U-78517 dihydrochloride 相关抗体:
分子量

593.63

Formula

C30H46Cl2N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

U-78517 dihydrochloride 相关分类

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Keywords:

U-78517133681-84-2U78517U 78517Drug DerivativeDrug derivativehypoxic injuryneonatal myocytesDCVC-induced lipid peroxidationrabbit renal cortical slicescerebral ischemiaDCVC-dependent cytotoxicitycreatine kinasecardiac myocytesnitrogen-based free radicalshypoxiaoxygen-based free radicalslactate dehydrogenasehydroxyl radicalslazaroidcardiovascular diseasefree radical interactionssuperoxide radicalssarcolemmal integrityDPPH radicalsInhibitorinhibitorinhibit

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产品名称：
U-78517 dihydrochloride
目录号：
HY-164295A
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