2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Vobramitamab duocarmazine

Vobramitamab duocarmazine  (Synonyms: AEX4089DC1; MGC018)

目录号: HY-145636
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Vobramitamab duocarmazine (AEX4089DC1; MGC018)，一种靶向 B7-H3 (CD276) 的人源化抗体-药物偶联物 (ADC)。Vobramitamab duocarmazine 由可裂解接头-Duocarmycin 有效负载，Vc-seco-DUBA (HY-128957)，与抗 B7-H3 人源化 IgG1κ 单克隆抗体偶联。Vobramitamab duocarmazine 具有抗肿瘤活性。

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Vobramitamab duocarmazine

Vobramitamab duocarmazine Chemical Structure

CAS No. : 2490556-51-7

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Vobramitamab duocarmazine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vobramitamab duocarmazine (AEX4089DC1; MGC018), a humanized antibody-drug conjugate (ADC) targeted against B7-H3 (CD276). Vobramitamab duocarmazine is comprised of the cleavable linker-Duocarmycin payload, Vc-seco-DUBA (HY-128957), conjugated to an anti-B7-H3 humanized IgG1κ monoclonal antibody. Vobramitamab duocarmazine has antineoplastic activity[1].

体外研究
(In Vitro)

Vobramitamab duocarmazine (MGC018；持续 7 天) 对B7-H3阳性的人类肿瘤细胞系 (包括 MDA-MB-468、A375.S2、PA-1、Calu-6、NCI-H1703、Hs700T、LN-229 和 SW48 癌细胞) 具有细胞毒性，IC50 值范围为 181-1447 pM。Vobramitamab duocarmazine 与 B7-H3 阳性肿瘤细胞共培养时，表现出对靶细胞阴性肿瘤细胞的旁观者杀伤作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vobramitamab duocarmazine 相关抗体:
体内研究
(In Vivo)

Vobramitamab duocarmazine (MGC018; 3-6 mg/kg; 静脉注射; 单次给药) 可剂量依赖性地抑制 MDA-MB-468 三阴性乳腺癌异种移植瘤的生长[1]。
Vobramitamab duocarmazine (MGC018; 3-10 mg/kg; 静脉注射; 单次给药) 可导致肿瘤快速消退，肿瘤体积减少 98%。在三阴性乳腺癌患者来源的异种移植 (PDX) 模型中[1]。
Vobramitamab duocarmazine (MGC018；3-10 mg/kg；静脉注射；单剂量) 在 PA-1 卵巢癌异种移植模型中显示出抗肿瘤活性。使用 Vobramitamab duocarmazine 分别以 10、6 和 3 mg/kg 的剂量治疗后，观察到肿瘤体积分别减少了 89%、91% 和 43%[1]。
Vobramitamab duocarmazine (MGC018；1-3 mg/kg；静脉注射；单次给药) 在 A375.S2 黑色素瘤异种移植模型中显示出抗肿瘤活性[1]。
Vobramitamab duocarmazine (MGC018；3-10 mg/kg；静脉注射；单次给药) 在 Calu-6 肺癌异种移植模型中显示出抗肿瘤活性。使用 Vobramitamab duocarmazine 分别以 10 mg/kg、6 mg/kg 和 3 mg/kg 的剂量治疗后，观察到肿瘤体积分别缩小了 91%、84% 和 72%[1]。
Vobramitamab duocarmazine (MGC018；3 mg/kg；每周一次，共 3 次或每两周一次，共 2 次；静脉注射) 对 B7-H3 表达异质性的患者来源前列腺癌和头颈癌异种移植模型显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 nude (homozygous) mice (Crl:CD1-Foxn1nu) and female SCID/CES1c KO mice (5-7 weeks old) injected with MDA-MB-468 cells[1]
Dosage: 3 mg/kg, 6 mg/kg
Administration: Tail vein injection; a single-dose
Result: Led to a dose-dependent decrease in tumor growth of MDA-MB-468 triple-negative breast cancer xenografts.
Animal Model: Female Athymic Nude-Foxn1nu mice (triple-negative breast cancer models)[1]
Dosage: 3 mg/kg
Administration: Tail vein injection; once a week; for 2 weeks
Result: Led to a rapid tumor regression, with a 98% reduction in tumor volume.
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Vobramitamab duocarmazine 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Vobramitamab duocarmazine2490556-51-7AEX4089DC1 MGC018MGC018MGC 018MGC-018Antibody-Drug Conjugates (ADCs)Antibody-Drug ConjugateshumanizedADCB7-H3CD276antineoplastic activityVc-seco-DUBAInhibitorinhibitorinhibit

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