2. Anti-infection
  3. HIV Reverse Transcriptase
  4. VRX-480773

VRX-480773 是一种高效的非核苷类逆转录酶抑制剂 (NNRTI)，用于 HIV 感染。VRX-480773 对 HIV-1 具有高度特异性，其对野生型 HIV-1 的 EC50 为 0.14 nM，不抑制 HIV-2、HBV 或 HCV，且对人 DNA 聚合酶 α/β 无影响。VRX-480773 对 Efavirenz (HY-10572) 耐药毒株仍有抑制性，其 EC50 大多 < 1 nM。VRX-480773 可用于研究艾滋病。

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VRX-480773

VRX-480773 Chemical Structure

CAS No. : 878670-89-4

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VRX-480773 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC50 for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC50s mostly < 1 nM. VRX-480773 can be used for research on AIDS[1].

IC50 & Target[1]

HIV-1 (WT)

0.14 nM (EC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa CC50
>= 3 μM
Compound: 24; VRX-480773
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by cellTiter-glo assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by cellTiter-glo assay
[PMID: 36708678]
MT4 CC50
5.821 μM
Compound: VRX-480773
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 4 days MTT method
Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 4 days MTT method
[PMID: 26162497]
MT4 EC50
0.00014 μM
Compound: VRX-480773
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method
[PMID: 26162497]
MT4 EC50
0.00023 μM
Compound: VRX-480773
Antiviral activity against HIV1 RES056 expressing reverse transcriptase K103N + Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method
Antiviral activity against HIV1 RES056 expressing reverse transcriptase K103N + Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity incubated for 4 days by MTT method
[PMID: 26162497]
MT4 EC50
0.14 μM
Compound: VRX-480733
Antiviral activity against HIV1 infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity by MTT assay
Antiviral activity against HIV1 infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity by MTT assay
[PMID: 23084898]
MT4 EC50
0.14 μM
Compound: VRX-480773
Antiviral activity against HIV1 3B in human MT4 cells assessed as protection of cell against virus-induced cytopathogenicity
Antiviral activity against HIV1 3B in human MT4 cells assessed as protection of cell against virus-induced cytopathogenicity
[PMID: 18824350]
MT4 EC50
0.14 μM
Compound: VRX-480773
Antiviral activity against HIV-1 3B infected in human MT4 cells assessed as inhibition of virus-induced syncytium formation after 5 days by MTT assay
Antiviral activity against HIV-1 3B infected in human MT4 cells assessed as inhibition of virus-induced syncytium formation after 5 days by MTT assay
[PMID: 21872971]
MT4 EC50
0.14 μM
Compound: VRX-480773
Antiviral activity against HIV-1 3B infected human MT4 cells assessed as inhibition in viral syncytium formation by MTT assay
Antiviral activity against HIV-1 3B infected human MT4 cells assessed as inhibition in viral syncytium formation by MTT assay
[PMID: 22883027]
MT4 EC50
0.23 μM
Compound: VRX-480733
Antiviral activity against HIV1 RES056 harboring reverse transcriptase K103N/Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity by MTT assay
Antiviral activity against HIV1 RES056 harboring reverse transcriptase K103N/Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathicity by MTT assay
[PMID: 23084898]
MT4 EC50
0.23 μM
Compound: VRX-480773
Antiviral activity against HIV-1 3B harboring RT K103N and Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced syncytium formation after 5 days by MTT assay
Antiviral activity against HIV-1 3B harboring RT K103N and Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced syncytium formation after 5 days by MTT assay
[PMID: 21872971]
MT4 EC50
0.23 μM
Compound: VRX-480773
Antiviral activity against HIV-1 RES056 harboring RT K103N/Y181C mutant gene infected human MT4 cells assessed as inhibition in viral syncytium formation by MTT assay
Antiviral activity against HIV-1 RES056 harboring RT K103N/Y181C mutant gene infected human MT4 cells assessed as inhibition in viral syncytium formation by MTT assay
[PMID: 22883027]
分子量

592.92

Formula

C23H19BrClN5O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VRX-480773 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VRX-480773878670-89-4VRX480773VRX 480773HIVReverse TranscriptaseHuman immunodeficiency virusNNRTIHIV-1drug resistancereverse transcriptase inhibitorcross-resistancepharmacokineticsantiviral activityInhibitorinhibitorinhibit

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产品名称：
VRX-480773
目录号：
HY-19869
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