2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. VUF-6884

VUF-6884 (Compound 7j) 是一种组胺受体 (Histamine Receptor) 配体，对人源 H4R 和 H1R 具有活性，其针对人源 H4R 的 pEC50 为 7.70、pKi 为 7.55，针对人源 H1R 的 pEC50 为 8.17、pKi 为 8.11。VUF-6884 可竞争性结合人源 H4R 的正构结合位点，从而取代组胺；同时在人源 H1R 上表现出反向激动活性。

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VUF-6884

VUF-6884 Chemical Structure

CAS No. : 3455-10-5

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VUF-6884 相关抗体

Top Publications Citing Use of Products

查看 Histamine Receptor 亚型特异性产品:

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VUF-6884 (Compound 7j) is a histamine receptor (Histamine Receptor) ligand with activity toward human H4R and H1R. Its pEC50 and pKi values against human H4R are 7.70 and 7.55, respectively, while those against human H1R are 8.17 and 8.11, respectively. VUF-6884 competitively binds to the orthosteric binding site of human H4R to displace histamine, and exhibits inverse agonist activity at human H1R[1].

分子量

327.81

Formula

C18H18ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VUF-6884 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VUF-68843455-10-5VUF6884VUF 6884Histamine Receptorhuman H1Rhuman H4Rhistamine receptor ligandhuman H2Rorthosteric binding siteinverse agonistic propertiesCRE-β-galactosidase reporter genehistaminehuman H3RSK-N-MC cellsInhibitorinhibitorinhibit

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目录号：
HY-124912
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