1. Anti-infection
  2. Antibiotic Fungal
  3. WF-3161

WF-3161 (FR900261) 是一种从真菌 Petriella guttulata 中分离得到的具有抗肿瘤活性的环四肽类抗生素。WF-3161 可抑制 Trichophyton asteroides 的生长,其 MIC 为 3 μg/mL。WF-3161 适用于 P-388 白血病相关研究。

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WF-3161

WF-3161 Chemical Structure

CAS No. : 86402-37-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WF-3161 (FR900261) is a cyclic tetrapeptide antibiotic isolated from the fungus Petriella guttulata with anti-tumor activity. WF-3161 inhibits the growth of Trichophyton asteroides with an MIC of 3 μg/mL. WF-3161 is applicable to research related to P-388 leukemia[1].

体外研究
(In Vitro)

WF-3161 (FR900261) (处理 48 至 72 h) 可抑制 Trichophyton asteroides 的生长,其 MIC 为 3 μg/mL[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

WF-3161 (FR900261) (6.3-100 mg/kg/天;腹腔注射;每日 1 次;肿瘤植入后第 1、2、3、4 天) 可呈剂量依赖性延长荷 P-388 白血病 BDF1 小鼠的生存期,其中最高测试剂量 (100 mg/kg/天,腹腔注射×4 天) 的 T/C 比值达 175%[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BDF1 (7-week-old female; intraperitoneal implantation of 1×106 P-388 lymphocytic leukemia cells)[1]
Dosage: 6.3-100 mg/kg/day
Administration: i.p.; once daily; days 1, 2, 3, and 4 post-tumor implantation
Result: Produced a median survival time (MST) of 17.5 days, a T/C ratio of 175%, and 10/10 survivors on day 5 at 100 mg/kg/day.
Produced an MST of 10.0 days, a T/C ratio of 100%, and 10/10 survivors on day 5 at 6.3 mg/kg/day.
Caused reduction in body weight at 100 mg/kg/day.
分子量

568.70

Formula

C31H44N4O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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