2. Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Others
  3. Ferroptosis Reactive Oxygen Species (ROS) Drug Derivative
  4. WMK-2

WMK-2 是一种 1,2,4,5-四氧杂环己烷衍生物和铁死亡 (ferroptosis) 诱导剂，具有广谱抗癌活性。WMK-2 可产生羟基自由基和脂质活性氧 (ROS)，从而诱导癌细胞及癌症干细胞发生铁死亡。WMK-2 可用于癌症的相关研究。

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WMK-2

WMK-2 Chemical Structure

CAS No. : 2814563-63-6

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WMK-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WMK-2 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer with broad-spectrum anticancer activity. WMK-2 generates hydroxyl radicals and lipid ROS to induce ferroptosis in cancer cells and cancer stem cells. WMK-2 can be used for the research of cancer[1].

体外研究
(In Vitro)

WMK-2 (37b) 对多种癌细胞系展现出强效且广谱的抗增殖活性。它可强效抑制 MDA-MB-231、HCT116、T47D、HepG2、HeLa、HEK293、MCF7、PLC、U2OS 和 Huh7 细胞，对应的 IC50 值分别为 0.38、0.6、0.62、0.7、1.6、1.6、2.4、2.7、3.4 和 3.8 μM。同时，WMK-2 对正常细胞表现出良好的选择性，针对 NIH3T3、bEnd.3 和 MDCK 细胞的 IC50 值分别为 4.6 μM、5.2 μM 和 9.5 μM，对应的选择性指数大于 7.6[1]。
WMK-2 (48 h) 可抑制贴壁型 HeyA8 卵巢癌细胞的活力，其 IC50 为 1.4 μM；孵育 48 h 后，对 HeyA8 卵巢癌干细胞球的活力抑制 IC50 为 1.1 μM，相对于非癌变 NIH3T3 细胞的选择性指数大于 11[1]。
WMK-2 可在 HeyA8 卵巢癌干细胞和 MDA-MB-231 乳腺癌细胞中诱导铁死亡[1]。
WMK-2 (1 μM; 6 h) 可在 MDA-MB-231 乳腺癌细胞中诱导显著的脂质 ROS 生成，证实其与铁死亡相关的脂质过氧化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WMK-2 相关抗体:
体内研究
(In Vivo)

WMK-2 (37b) (腹腔注射，5-10 mg/kg) 可有效抑制 MDA-MB-231 乳腺癌和 HEYA8 CSC 卵巢癌异种移植裸鼠的肿瘤生长，且未观察到组织病理学异常[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (female, HEYA8 CSC xenograft model)[1]
Dosage: 5 mg/kg; 10 mg/kg
Administration: i.p.
Result: Effectively inhibited ovarian tumor growth compared with vehicle control.
Showed well-tolerated safety profile with no abnormal behavior or weight loss noted during treatment period.
分子量

726.68

Formula

C38H49BrNO6P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WMK-2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WMK-22814563-63-6WMK2WMK 2FerroptosisReactive Oxygen Species (ROS)Drug DerivativeDrug derivativeovarian cancercolon cancercancer cellscancer stem cellsferroptosisHeLaliver cancercervical cancerMDA-MB-231breast cancerInhibitorinhibitorinhibit

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