2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. WYE-103914

WYE-103914 是一种口服活性的 α7 nAChR (EC50 = 0.49 µM for rat α7 nAChR, EC50 = 0.57 µM for human α7 nAChR) 激动剂。WYE-103914 在多个认知模型中表现出增强记忆的能力。WYE-103914 与抗精神病药物联合应用。WYE-103914 可用于精神分裂症的研究。

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WYE-103914

WYE-103914 Chemical Structure

CAS No. : 1204607-09-9

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WYE-103914 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WYE-103914 is an orally active α7 nAChR (EC50 = 0.49 µM for rat α7 nAChR, EC50 = 0.57 µM for human α7 nAChR) agonist. WYE-103914 exhibits the ability to enhance memory in multiple cognitive models. WYE-103914 is used in combination with antipsychotic drugs. WYE-103914 can be used for research on schizophrenia[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
1.3 μM
Compound: 16
Binding affinity to human ERG expressed in CHO cells
Binding affinity to human ERG expressed in CHO cells
[PMID: 20465311]
GH4-C1 EC50
0.07 μM
Compound: 16
Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR
Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR
[PMID: 20465311]
GH4-C1 EC50
490 nM
Compound: 16
Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells by whole cell patch-clamp electrophysiology
Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells by whole cell patch-clamp electrophysiology
[PMID: 20465311]
HEK293 IC50
> 30 μM
Compound: 16
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay
Agonist activity at human 5HT3A receptor expressed in HEK293 cells by FLIPR assay
[PMID: 20465311]
分子量

370.46

Formula

C21H27FN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WYE-103914 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WYE-1039141204607-09-9WYE103914WYE 103914nAChRNicotinic acetylcholine receptorsα7 nAChRantipsychoticschizophreniaInhibitorinhibitorinhibit

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