2. Others
  3. Drug Derivative
  4. Xanthofulvin

Xanthofulvin (SM-216289) 是 semaphorin 3A 抑制剂。Xanthofulvin 可阻断其与受体结合、抑制生长锥塌陷，体内能加速大鼠嗅神经再生。Xanthofulvin 可用于创伤性神经元损伤的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Xanthofulvin

Xanthofulvin Chemical Structure

CAS No. : 151466-15-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Xanthofulvin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Xanthofulvin (SM-216289) is an inhibitor of semaphorin 3A. Xanthofulvin blocks its binding to receptors, inhibits growth cone collapse, and accelerates olfactory nerve regeneration in rats in vivo. Xanthofulvin can be used in studies related to traumatic neuronal injury[1][2].

体外研究
(In Vitro)

Xanthofulvin (0-1 μg/mL; 2 h) 可强效抑制 Semaphorin3A (Sema3A) 诱导的体外培养 E7 鸡背根神经节神经元生长锥塌陷，其 IC50 为 0.09 μg/mL，且在无 Sema3A 存在的情况下，不会改变 DRG 细胞的形态[1]。
Xanthofulvin (0.16-2 μM; 0-2 h) 可强效抑制 Sema3A 诱导的 E7 鸡背根神经节 (DRG) 外植体的生长锥塌陷，其 IC50 为 0.16 μM，且在低于 2 μM 的浓度下可完全阻断塌陷[2]。
Xanthofulvin (0-4.0 μM; 0-2 days) 可剂量依赖性地阻断与表达 Sema3A 的 COS7 细胞共培养的 E8 鸡背根神经节 (DRG) 外植体中由 Sema3A 诱导的轴突排斥作用[2]。
Xanthofulvin (5-500 μM; 48 h) 在浓度高达 500 μM、孵育 48 h 的条件下，对 COS7 细胞无细胞毒性[2]。
Xanthofulvin 可剂量依赖性地抑制 Sema3A-AP 与表达 NP-1 的 COS7 细胞的结合，其 IC50 为 2.9 μM，且在 5 μM 时可显著降低结合作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Xanthofulvin 相关抗体:

Cell Cytotoxicity Assay[2]

Cell Line: COS7 cells
Concentration: 5 μM; 50 μM; 500 μM
Incubation Time: 48 h
Result: Showed no growth inhibition of COS7 cells at concentrations up to 500 μM.
体内研究
(In Vivo)

Xanthofulvin (每日 6 μg/6 μL；通过套管和渗透泵在损伤部位持续局部给药) 可显著加速轴突切断大鼠的嗅神经再生[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (male, 6.5 weeks old, olfactory nerve axotomy model)[2]
Dosage: 6 μg/6 μl/day
Administration: local continuous via cannula and osmotic pump at the injury site
Result: Achieved a mean olfactory nerve regeneration score of 8.3 at 2 weeks post-axotomy.
Achieved a mean olfactory nerve regeneration score of 5.2 at 3 weeks post-axotomy, which was significantly lower than the vehicle control group.
分子量

578.43

Formula

C28H18O14
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Xanthofulvin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xanthofulvin151466-15-8SM-216289SM216289SM 216289Drug DerivativeDrug derivativetraumatic neuronal injurydorsal root ganglia neuronsolfactory nerve regenerationCOS7 cellssemaphorin 3Arat modelE7 chick dorsal root ganglia neuronschitin synthase IIneuropilin-1E14 rat DRG explantsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Xanthofulvin
目录号：
HY-N14827
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z