2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Mas-related G-protein-coupled Receptor (MRGPR) Calcium Channel Glycosidase
  4. XAT-13

XAT-13 是一种具有口服活性的抗过敏剂。XAT-13 可结合 MRGPRX2 的活性口袋，抑制 C48/80 诱导的钙内流 (Calcium influx)、β-hexosaminidase 释放。XAT-13 可用于假性变态反应疾病的研究。

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XAT-13

XAT-13 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

XAT-13 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of MRGPRX2, and inhibits C48/80-induced calcium influx and β-hexosaminidase release. XAT-13 can be used for the research of pseudo-allergic diseases[1].

IC50 & Target[1]

MRGPRX2

 

体外研究
(In Vitro)

XAT-13 (最高浓度 100 μmol/L) 在 LAD2 细胞中无细胞毒性[1]。
XAT-13 (25-100 μmol/L) 呈剂量依赖性抑制 C48/80 诱导的 LAD2 细胞中 β-hexosaminidase 释放，其 IC50 为 57.27 ± 0.13 μmol/L，且效力优于 Imperatorin (HY-N0285)[1]。
XAT-13 (25-100 μmol/L) 可剂量依赖性地抑制 C48/80 诱导的 MRGPRX2-HEK293 细胞内钙内流[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

XAT-13 相关抗体:
体内研究
(In Vivo)

XAT-13 (4-16 mg/kg；灌胃) 对 C48/80 诱导的小鼠局部过敏具有抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C48/80-induced local allergy[1]
Dosage: 4, 8, 16 mg/kg
Administration: p.o.
Result: Attenuated the hind paws thickness.
Resulted in statistically significant differences in serum histamine levels.
分子量

336.34

Formula

C20H16O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

XAT-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XAT-13XAT13XAT 13Mas-related G-protein-coupled Receptor (MRGPR)Calcium ChannelGlycosidaseCa2+ channelsCa channelsMRGPRX2-HEK293 cellsMRGPRX2β-hexosaminidaseLAD2 cellsIL-8MCP-1mast cell degranulationhistaminecalcium influxpseudo allergic diseasesInhibitorinhibitorinhibit

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目录号：
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