2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Ferroptosis Reactive Oxygen Species (ROS)
  4. YL3147

YL3147 是一种铁死亡 (ferroptosis) 抑制剂。YL3147 也是自由基捕获抗氧化剂，可直接阻止脂质过氧化的扩散，阻断铁死亡。YL3147 在小鼠心肌病模型中发挥显著的心脏保护作用。YL3147 可用于心肌病的相关研究。

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YL3147

YL3147 Chemical Structure

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YL3147 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YL3147 is a ferroptosis inhibitor. YL3147 also acts as a radical-trapping antioxidant that directly prevents the spread of lipid peroxidation and blocks ferroptosis. YL3147 exerts significant cardioprotective effects in mouse cardiomyopathy models. YL3147 can be used in studies related to cardiomyopathy[1].

体外研究
(In Vitro)

YL3147 (48 h) 可保护 ES-2 、AC16、HT1080 、PANC-1 细胞免受 Erastin (HY-15763) 诱导的铁死亡，EC50 分别为 0.8、0.8 、0.43 和0.92 nM[1]。
YL3147 (0.01-1 μM; 10-12 h) 可有效减轻 Erastin (HY-15763) 诱导的 ES-2 和 AC16 细胞脂质过氧化，和 ES-2 细胞内 ROS 生成[1]。
YL3147 (72 h) 对多种人正常细胞系的细胞毒性较低，其 CC50 值大于 10 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YL3147 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: multiple normal human cell lines (BEAS-2B, HUVEC, AC16, GES-1, HK-2, HaCaT, ARPE-19, hTERT-HPNE)
Concentration: /
Incubation Time: 72 h
Result: Exhibited minimal cytotoxicity, with CC50 values >10 μM across all tested normal cell lines.
药代动力学
(Parmacokinetics)
Species Dose Route AUC0-t AUC0-∞ Cmax CL Vz/F T1/2 Tmax MRT0-t Bioavailability
Mice[1] 10 mg/kg p.o. 3794.61 μg/L·h 3800.28 μg/L·h 584.18 μg/L 2.63 L/h/kg 9.28 L/kg 2.44 h 1.00 h 4.65 h 53.04 %
Mice[1] 10 mg/kg i.v. 7022.24 μg/L·h 7078.71 μg/L·h 2537.57 μg/L 1.49 L/h/kg 6.94 L/kg 3.35 h 0.08 h 4.31 h /
Mice[1] 10 mg/kg i.p. 5033.34 μg/L·h 5050.96 μg/L·h 549.69 μg/L 1.98 L/h/kg 8.31 L/kg 2.91 h 0.25 h 6.08 h /
体内研究
(In Vivo)

YL3147 (10-30 mg/kg; i.p.; single dose/3 weeks) 在 Doxorubicin (HY-15142A) 诱导的急慢性心肌病小鼠模型中具有心脏保护作用[1]。
YL3147 (200 mg/kg; p.o.; single dose) 在 BALB/c 小鼠中耐受性良好，未检测到急性毒性或器官损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (8-week-old male; acute Doxorubicin-induced cardiomyopathy model)[1]
Dosage: 10 mg/kg; 30 mg/kg
Administration: i.p.; single dose 2 hours prior to doxorubicin
Result: Significantly improved cardiac function, including increased ejection fraction, cardiac output, and stroke volume, relative to vehicle-treated mice.
Prolonged survival and reduced mortality relative to vehicle-treated mice.
Markedly reduced doxorubicin-induced elevation in serum lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) levels.
Suppressed increases in myocardial malondialdehyde (MDA) content and mRNA levels of cardiac stress gene Myh7 and ferroptosis-related marker Ptgs2.
Preserved cardiomyocyte structure, attenuated cardiac fibrosis, and reduced 4-hydroxynonenal (4-HNE) immunopositivity in heart tissue.
Animal Model: C57BL/6 (8-week-old male; chronic doxorubicin-induced cardiomyopathy model)[1]
Dosage: 30 mg/kg
Administration: i.p.; daily; 3 consecutive weeks, starting 3 days before first doxorubicin dose
Result: Reduced mortality and attenuated weight loss relative to vehicle-treated mice.
Attenuated doxorubicin-induced ventricular remodeling, with improved ejection fraction, fractional shortening, cardiac output, and stroke volume relative to vehicle-treated mice.
Reduced serum levels of cardiac injury markers LDH and CK-MB relative to vehicle-treated mice.
Decreased myocardial MDA content and attenuated upregulation of Myh7 and Ptgs2 mRNA expression relative to vehicle-treated mice.
Preserved cardiomyocyte architecture, reduced cardiac fibrosis, and lowered tissue lipid peroxidation (4-HNE immunopositivity) relative to vehicle-treated mice.
Caused no significant changes in body weight, cardiac function parameters, serum organ damage markers (ALT, AST, creatinine), or histopathological architecture of major organs when used as monotherapy.
分子量

402.51

Formula

C25H27FN4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YL3147 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YL3147YL 3147YL-3147FerroptosisReactive Oxygen Species (ROS)HT1080 cellsferroptosisES-2 cellscardiomyopathylipid peroxidationAC16 cellsInhibitorinhibitorinhibit

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