2. Apoptosis
  3. Apoptosis
  4. Z19024498

Z19024498 是一种热增敏剂。Z19024498 可在热应激条件下抑制 SAFB 颗粒形成。Z19024498 可增强热应激诱导的凋亡 (Apoptosis)。Z19024498 协同热应激对宫颈癌具有抗癌活性。

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Z19024498

Z19024498 Chemical Structure

CAS No. : 1005147-23-8

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Z19024498 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Z19024498 is a heat sensitizer. Z19024498 inhibits SAFB granule formation under heat stress conditions. Z19024498 enhances heat stress-induced Apoptosis. Z19024498 exerts anticancer activity against cervical cancer in synergy with heat stress[1].

体外研究
(In Vitro)

Z19024498 (37°C 预孵育 1 h，随后在 43°C 热应激条件下共同孵育 1 h，之后在无该化合物的 37°C 环境下恢复 24 h) 可显著增强热应激诱导的 HeLa 细胞生长抑制[1]。
Z19024498 (0-20 μM；37°C 预孵育 1 h，随后与 43°C 热应激共孵育 1 h) 可抑制热应激 HeLa 细胞中独立 SAFB 颗粒的形成 (IC50 = 10.7 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Z19024498 相关抗体:

Cell Viability Assay[1]

Cell Line: HeLa, H1299, AsPC1, HepG2, HEK293T
Concentration: 0-25 μM (GI50 determination); 5 μM (post-heat stress incubation)
Incubation Time: 37 °C for 1 h, followed by incubation at 43 °C for 1 h, followed by 24 h incubation at 37°C with 5 μM compound
Result: Achieved a GI50 of 5.3 μM (37°C) and 3.1 μM (43°C), with a TER of 1.7 in HeLa cells.
Achieved a GI50 of 4.1 μM (37°C) and 1.6 μM (43°C), with a TER of 2.6 in H1299 cells.
Achieved a GI50 of 18.7 μM (37°C) and 15.6 μM (43°C), with a TER of 1.2 in AsPC1 cells.
Achieved a GI50 of 40.8 μM (37°C) and 3.4 μM (43°C), with a TER of 12 in HepG2 cells.
Achieved a GI50 of 10.5 μM (37°C) and 6.0 μM (43°C), with a TER of 1.8 in HEK293T cells.
Produced all TER values >1.0, indicating synergistic enhancement of hyperthermic effects.
体内研究
(In Vivo)

Z19024498 (3 mg/kg；腹腔注射；2 次) 单独使用可轻度缩小 HeLa 异种移植瘤小鼠的肿瘤体积并延长其生存期，且与热应激联合使用时可产生显著的肿瘤生长抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c-nu/nu nude mice (6-week-old female; HeLa cell xenograft)[1]
Dosage: 3 mg/kg
Administration: i.p.; twice (days 0 and 8, 1 hour before hyperthermia)
Result: Reduced tumor volume compared with DMSO-treated mice.
Extended lifespan slightly compared with DMSO-treated controls.
Combined with hyperthermia, significantly suppressed tumor growth compared with DMSO, Z19024498 alone, or hyperthermia alone, with significantly reduced tumor volumes on day 14 and significantly lower tumor weight on day 28 compared with hyperthermia alone.
Extended lifespan slightly compared with hyperthermia alone when combined with hyperthermia.
Caused no changes in body weight, indicating minimal to no physiological toxicity.
分子量

332.23

Formula

C14H19Cl2N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Z19024498 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z190244981005147-23-8Z 19024498Z-19024498Apoptosiscervical cancerSAFB granulesHeLa cellspancreatic adenocarcinomaHSF1 granulesheat shock transcription factor 1apoptosislung cancerxenograft modelsscaffold attachment factor BInhibitorinhibitorinhibit

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