2. Protein Tyrosine Kinase/RTK TGF-beta/Smad Stem Cell/Wnt
  3. VEGFR RUNX
  4. Zinc borate

Zinc borate 是一种生物活性无机物，具有成骨诱导、促血管生成、抗氧化、抗诱变及细胞毒性等特性。在骨组织工程领域，Zinc borate 常被掺入壳聚糖支架中。Zinc borate 通过释放锌离子和硼离子，诱导人牙髓干细胞向成骨细胞分化、上调骨相关基因表达并促进钙沉积。Zinc borate 还通过上调血管内皮生长因子等关键因子来促进血管形成。Zinc borate 表现出清除自由基的抗氧化能力，并能特异性降低特定条件下的致突变性。Zinc borate 会降低小鼠成纤维细胞的存活率，但其可用于骨组织工程相关研究。

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Zinc borate

Zinc borate Chemical Structure

CAS No. : 1332-07-6

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Zinc borate 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Zinc borate is a bioactive inorganic substance with properties including osteogenic induction, pro-angiogenesis, antioxidation, antimutagenesis and cytotoxicity. In the field of bone tissue engineering, Zinc borate is often incorporated into chitosan scaffolds. By releasing zinc ions and borate ions, Zinc borate induces the differentiation of human dental pulp stem cells into osteoblasts, upregulates the expression of bone-related genes and promotes calcium deposition. Zinc borate also promotes angiogenesis by upregulating key factors such as vascular endothelial growth factor. Zinc borate exhibits antioxidant capacity to scavenge free radicals, and can specifically reduce mutagenicity under specific conditions. Zinc borate reduces the survival rate of mouse fibroblasts, but it can still be used in studies related to bone tissue engineering[1][2].

IC50 & Target

RUNX2

 

体外研究
(In Vitro)

Zinc borate (1.0% (w/v); 7-21 d) 负载于壳聚糖支架时，可支持脱落乳牙干细胞 (SHEDs)，使细胞存活率显著提升，在 570 nm 处的吸光度值分别约为 0.29、0.41 和 0.57；还使 ALP 活性显著上调[1]。
Zinc borate (1.0% (w/v); 7-21 d) 在壳聚糖支架中可支持 SHEDs，使其在成骨分化过程中显著上调成骨相关基因 (Runx2，OPN 和 OCN) 及血管生成相关基因 (VEGF、Ang-1) 的表达[1]。
Zinc borate (1 mg/mL; 30 min) 在无细胞实验中表现出较低的 DPPH 自由基清除活性，在 1 mg/mL 时的抑制率为 13.50%[2]。
Zinc borate (0.04-0.2 mg; 72 h) 对 4-NPD 诱导的鼠伤寒沙门氏菌 TA98 菌株致突变性表现出低抗突变活性，但在 TA100 菌株中对叠氮化钠诱导的致突变性无抗突变活性[2]。
Zinc borate (0.3-76.19 µg/mL; 24-72 h) 对小鼠成纤维细胞 L929 表现出细胞毒性，其在 24 h 时的 IC50 值为 40.70 µg/mL，在 72 h 时为 32.93 µg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Zinc borate 相关抗体:

Real Time qPCR[1]

Cell Line: stem cells from human exfoliated deciduous teeth (SHEDs)
Concentration: 1.0% (w/v)
Incubation Time: 7, 14, 21 days (cell culture); 45 cycles (RT-PCR)
Result: Showed the highest expression of Runx2 after 14 days of culture.
Showed the highest expression of OPN and OCN after 21 days of culture.
Exhibited high expression of VEGF and Ang-1 across culture time points.
Had all gene expression levels significantly higher than those in pure chitosan scaffolds.

Immunofluorescence[1]

Cell Line: stem cells from human exfoliated deciduous teeth (SHEDs)
Concentration: 1.0% (w/v)
Incubation Time: 7, 21 days (cell culture); 1 h (primary antibody incubation); 1 h (secondary antibody incubation)
Result: Showed notable expression of the early osteoblastic marker BMP-2 after 7 days of culture.
Showed notable expression of the late osteoblastic marker OCN after 21 days of culture.
分子量

313.76

Formula

Zn3(BO3)2
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
纯度 & 产品资料
参考文献

Zinc borate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zinc borate1332-07-6VEGFRRUNXVascular endothelial growth factor receptorRunt-related transcription factorsSHEDsDPPH free radicalsvascular endothelial growth factor4-nitro-o-phenylenediaminechitosan scaffoldsSalmonella typhimurium TA98 strainmouse fibroblast cellsSalmonella typhimurium TA100 strainhuman dental stem cellsangiopoietin-1Inhibitorinhibitorinhibit

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