2. Epigenetics
  3. Histone Methyltransferase
  4. ZJH-16

ZJH-16 (Compound 11e) 是一种具有口服活性的 EED 抑制剂 (IC50 = 2.72 nM，Kd = 4.4 nM)。ZJH-16 抑制淋巴瘤细胞的生长，降低 H3K27 三甲基化水平。ZJH-16 在淋巴瘤动物模型中抑制肿瘤生长。ZJH-16 可用于淋巴瘤等癌症的研究。

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ZJH-16

ZJH-16 Chemical Structure

CAS No. : 2877017-58-6

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ZJH-16 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZJH-16 (Compound 11e) is an orally active EED inhibitor (IC50 = 2.72 nM, Kd = 4.4 nM). ZJH-16 inhibits the growth of lymphoma cells and reduces H3K27 trimethylation levels. ZJH-16 inhibits tumor growth in lymphoma animal models. ZJH-16 can be used for research on lymphoma and other cancers[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
KARPAS-422 IC50
0.22 μM
Compound: 11e; ZJH-16
Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay
Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay
[PMID: 36580346]
Pfeiffer IC50
0.13 μM
Compound: 11e; ZJH-16
Antiproliferative activity against human Pfeiffer cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay
Antiproliferative activity against human Pfeiffer cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay
[PMID: 36580346]
分子量

330.34

Formula

C18H14N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZJH-16 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZJH-162877017-58-6ZJH16ZJH 16Histone MethyltransferaseInhibitorinhibitorinhibit

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