2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. ZL-1218

ZL-1218 是一种靶向 CCR8 的选择性人源化抗体。ZL-1218 能诱导抗体依赖性细胞介导的细胞毒性作用，从而通过自然杀伤细胞清除表达 CCR8 的调节性 T 细胞。ZL-1218 可阻断 CCR8 的配体 CCL1 与其受体结合，并通过抑制 CCR8+ 细胞的趋化作用，从而减少 Treg 的募集。 ZL-1218 能够剂量依赖性地减少瘤内 Treg 细胞数量。当其与抗 anti-PD 抗体联用时，抗肿瘤活性得到增强。ZL-1218 可用于实体瘤的相关研究。

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ZL-1218

ZL-1218 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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3.  试用装只面向终端客户。

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ZL-1218 相关抗体

Top Publications Citing Use of Products

查看 CCR 亚型特异性产品:

查看所有亚型
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZL-1218 is a selective humanized IgG1 antibody, targeting CCR8. ZL-1218 induces antibody-dependent cellular cytotoxicity (ADCC), leading to NK cell-mediated depletion of CCR8-expressing regulatory T cells (Tregs). ZL-1218 blocks the binding of the CCR8 ligand CCL1 to CCR8 and reduces Treg recruitment by inhibiting the chemotaxis of CCR8+ cells. ZL-1218 reduces intratumoral Treg levels in a dose-dependent manner. ZL-1218 exerts enhanced antitumor activity when combined with the anti-PD-1 antibody. ZL-1218 can be used for solid tumour research[1][2][3].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target[1]

CCR8

 

体外研究
(In Vitro)

ZL-1218 在小鼠解离肿瘤细胞中耗竭约 50% 的调节性 T 细胞[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZL-1218 相关抗体:
体内研究
(In Vivo)

ZL-1218 在携带同系肿瘤的人源化 CCR8 基因敲入小鼠模型中可减少瘤内调节性 T 细胞、以剂量依赖方式抑制肿瘤生长；同时，在不影响外周 Treg 细胞的情况下，提高瘤内 CD8+T 细胞与 Treg 细胞的比例[1][2]。
ZL-1218 (100 mg/kg，静脉注射，五周) 在非人灵长类动物中具有良好的安全性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

1237  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZL-1218 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZL-1218ZL1218ZL 1218CCRCC chemokine receptorhumanized antibodyADCCT cellsantitumor activitycancerInhibitorinhibitorinhibit

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产品名称：
ZL-1218
目录号：
HY-P991944
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