2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. α-Glucosidase-IN-43

α-Glucosidase-IN-43 (compound AS14) 是 α-葡萄糖苷酶抑制剂 (IC50: 4.32 μM)，具有急性降血糖活性。α-Glucosidase-IN-43 具有安全性和体内效力，它对小鼠正常成纤维细胞无毒，并能够拯救链脲佐菌素 (HY-13753) 诱导糖尿病大鼠。α-Glucosidase-IN-43 可用于糖尿病患者餐后高血糖的研究。

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α-Glucosidase-IN-43

α-Glucosidase-IN-43 Chemical Structure

CAS No. : 3018963-27-1

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α-Glucosidase-IN-43 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor (IC50: 4.32 μM) with acute hypoglycemic activity. α-Glucosidase-IN-43 exhibits safety and in vivo efficacy, is nontoxic to normal mouse fibroblasts, and is able to rescue streptozotocin (HY-13753)-induced diabetic rats. α-Glucosidase-IN-43 can be used to study postprandial hyperglycemia in diabetic patients[1].

IC50 & Target

IC50: 4.32 μM (α-Glucosidase)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
L929 IC50
> 100 μM
Compound: AS14
Cytotoxicity against mouse L929 cells assessed reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against mouse L929 cells assessed reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 37984299]
分子量

461.55

Formula

C27H31N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

α-Glucosidase-IN-43 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-433018963-27-1GlycosidaseCoumarinDiabetes mellitusThymolTriazoleα-glucosidaseInhibitorinhibitorinhibit

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