Roscovitine
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Roscovitine 속성
- 녹는점
- 106～107℃
- 끓는 점
- 577.5±60.0 °C(Predicted)
- 밀도
- 1.3
- 저장 조건
- -20°C
- 용해도
- DMSO(가온 시 최대 10mg/ml) 또는 에탄올(최대 10mg/ml)에 용해됩니다.
- 산도 계수 (pKa)
- 14.56±0.10(Predicted)
- 물리적 상태
- 흰색에서 회백색 고체
- 색상
- 하얀색
- 생물학적 소스
- synthetic (organic)
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다.
- InChI
- InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
- InChIKey
- BTIHMVBBUGXLCJ-OAHLLOKOSA-N
- SMILES
- C(O)[C@H](NC1=NC(NCC2=CC=CC=C2)=C2C(=N1)N(C(C)C)C=N2)CC
- CAS 데이터베이스
- 186692-46-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 안전지침서 | 22-24/25 | ||
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| WGK 독일 | 3 | ||
| HS 번호 | 29335990 | ||
| 스토리지 클래스 | 11 - Combustible Solids |
| 그림문자(GHS): |
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| 신호 어: | Warning | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Roscovitine C화학적 특성, 용도, 생산
정의
ChEBI: 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.일반 설명
A potent, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks) that exhibits about ten-fold greater efficacy towards p34cdk1 and p33cdk2 and twenty-fold greater efficacy towards p33cdk5 relative to Olomoucine (Cat. No. 495620). Inhibits p34cdk1/cyclin B (IC50 = 650 nM), p33cdk2/cyclin A (IC50 = 700 nM), p33cdk2/cyclin E (IC50 = 700 nM), and p33cdk5/p35 (IC50 = 200 nM) by competing for the ATP binding domain of the kinases. Exhibits reduced sensitivity towards related kinases including ERK1 and ERK2 (IC50 = 34 μM and 14 μM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 μM, including p34cdk4/cyclin D1 and p40cdk6/cyclin D2. Compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. A 50 mM (5 mg/282 μl) solution of Roscovitine (Cat. No. 557364) in DMSO is also available.Anticancer Research
Roscovitine a derivative of olomoucine which is isolated from Raphanus sativus isunder clinical trials (Shoeb 2006).Roscovitine 준비 용품 및 원자재
원자재
준비 용품
Roscovitine 공급 업체
글로벌( 265)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29830 | 58 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49977 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32470 | 58 |
| Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 |
16728589@qq.com | CHINA | 272 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
Roscovitine 관련 검색:
셀루메티닙 PD0332991이세티오네이트 셀리시클립 (S)-로스코비틴
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
PD 0332991 HCl
Dasatinib
Alisertib (MLN8237)
Brivanib
BML-259
Roscovitine
NS-398
S-ROSCOVITINE 98% (HPLC),ROSCOVITINE, (S)-ISOMER,(S)-ROSCOVITINE
RS-ROSCOVITINE 98% (HPLC)
ROSCOVITINE, 99+%
ROSCOVITINE, IMMOBILIZED
(R)-ROSCOVITINE, >95%
OLOMOUCINE II