눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
6,6-디메틸-3-아자비시클로[3.1.0]헥산보세프레비르핵심중간체 C화학적 특성, 용도, 생산
용도
6,6-DiMethyl-3-azabicyclo[3.1.0]hexane Boceprevir is a Key interMediate.
Synthesis
6,6-Dimethyl-3-aza-bicyclo[3.1.01]hexane was synthesised using carbonic anhydride (II) as the starting material. First, in the presence of a nitrogen source, compound II reacted with the catalyst (4-N,N-dimethylaminopyridine) to form the intermediate 6,6-Dimethyl-3-aza-bicyclo[3.1.0]hexane-2,4-dione (III). Finally, compound III was mixed with a THF solution of LiAlH₄ to continue the reaction. The reaction route is as follows:
![6,6-디메틸-3-아자비시클로[3.1.0]헥산보세프레비르핵심중간체](CAS/GIF/943516-54-9.gif)
![synthesis of 6,6-Dimethyl-3-aza-bicyclo[3.1.01]hexane](http://hg.y866.cn/chemistry/NewsImg/2025-12-30/6390271125377549316037104.png "synthesis of 6,6-Dimethyl-3-aza-bicyclo[3.1.01]hexane")