双氯芬酸二乙胺
| 中文名称 | 双氯芬酸二乙胺 |
|---|---|
| 中文同义词 | 双氯芬酸二乙胺 5G;2-(2,6-二氯苯胺)苯乙酸二乙胺盐;双氯芬酸二乙胺盐原料药;湖北双氯芬酸二乙胺盐原料药;医药级双氯芬酸二乙胺盐;双氯芬酸二乙胺盐原料药生产厂家;双氯芬酸二乙胺;2-((2,6-二氯苯基)氨基)苯乙酸二乙胺盐 |
| 英文名称 | Diclofenac diethylamine |
| 英文同义词 | 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with n-ethylethanamine;Diclofenac Diethyl Amine Salt;2-[2-(2,6-dichloroanilino)phenyl]acetic acid;Diclofenac diethylamine, >=99%;Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, compd. with N-ethylethanamine (1:1);2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with n-ethylethanamine (1:1);DICLOFENAC DIETHYLAMINE;n-ethylethanamine 2-[(2,6-dichlorophenyl)amino]benzeneacetate |
| CAS号 | 78213-16-8 |
| 分子式 | C18H22Cl2N2O2 |
| 分子量 | 369.29 |
| EINECS号 | 616-599-2 |
| 相关类别 | 解热镇痛抗炎药;原料;化合物：原料药：解热镇痛类;医药原料药;医药原料;小分子抑制剂;解热镇痛类;神经系统用药;食品添加剂;解热镇痛;原料药;解热镇痛原料药;API;中间体;科研试剂;原料;其他类;化工原料;化学试剂 |
| Mol文件 | 78213-16-8.mol |
| 结构式 |  |
双氯芬酸二乙胺 性质
| 熔点 | 145-148°C |
|---|---|
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | DMF：30mg/mL； DMSO：10mg/mL；乙醇：30mg/mL； PBS（pH 7.2）：2 mg/mL |
| 形态 | 结晶固体 |
| 颜色 | 白色至米白色 |
| 稳定性 | 吸湿性 |
| InChI | InChI=1S/C14H11Cl2NO2.C4H11N/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;1-3-5-4-2/h1-7,17H,8H2,(H,18,19);5H,3-4H2,1-2H3 |
| InChIKey | ZQVZPANTCLRASL-UHFFFAOYSA-N |
| SMILES | C1(=CC=CC=C1CC(=O)O)NC1C(Cl)=CC=CC=1Cl.N(CC)CC |
| CAS 数据库 | 78213-16-8(CAS DataBase Reference) |
|
Human COX-2 1.3 nM (IC 50 , in CHO cells) |
Human COX-1 4 nM (IC 50 , in CHO cells) |
Ovine COX-2 0.84 μM (IC 50 ) |
Ovine COX-1 5.1 μM (IC 50 ) |
Diclofenac diethylamine抗炎，退热，和镇痛作用的主要作用机制被认为是通过抑制环氧合酶(COX)，从而抑制前列腺素合成。它通过抑制细菌DNA合成发挥出抑菌活性。COX的抑制也会减少胃上皮细胞中的前列腺素，使其对胃酸的腐蚀更敏感。这也是diclofenac diethylamine的主要副作用。Diclofenac diethylamine阻断COX2-同工酶(大约10倍)，具有低到中度的选择性，因此，diclofenac diethylamine造成的胃肠疾病的发生率比消炎痛和阿司匹林低。
Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal
51
Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days.
Diclofenac (10 mg/kg; administered via oral route just prior to induction of inflammation) shows in vivo anti-inflammatory activity in Wistar rats.
| Animal Model: | Male Sprague-Dawley rats (150±200 g) |
| Dosage: | 3 mg/kg |
| Administration: | Oral administration, b.i.d., for 5 days |
| Result: | Resulted in a significant increase in faecal 51 Cr excretion. |
| Animal Model: | Wistar rats (150-175 g) bearing Formalin-induced rat foot paw edema model |
| Dosage: | 10 mg/kg |
| Administration: | Administered via oral route just prior to induction of inflammation |
| Result: | Showed in vivo anti-inflammatory activity (% edema inhibition=29.2, 1 h; 22.2, 3 h; 20, 6 h). |
安全信息
双氯芬酸二乙胺 化学药品说明书
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/09/19 | S3063 | 双氯芬酸二乙胺 Diclofenac Diethylamine | 78213-16-8 | 50mg | 791.41元 |
| 2025/05/22 | HY-15036A | 双氯芬酸二乙胺 Diclofenac diethylamine | 78213-16-8 | 500mg | 350元 |