107-16-4 (羟基乙腈,Glycolonitrile)

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Section I.Chemical Product and Company Identification
    Chemical Name        Glycolonitrile    
    (ca. 52% in Water, ca. 9.7mol/L) (stabilized with H2SO4)
    Portland OR
    Acetonitrile, 2-hydroxy- (CA INDEX NAME);
    Synonym
    Formaldehyde Cyanhydrin; Hydroxyacetonitrile
    Chemical Formula        C2H3NO    
    107-16-4
    CAS Number

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Section II.        Composition and Information on Ingredients    
    Chemical Name        CAS Number Percent (%)        TLV/PEL        Toxicology Data    
    Glycolonitrile        107-16-4        Not available. Not available.        Rat LD50 (oral) 8 mg/kg    
    (ca. 52% in Water, ca. 9.7mol/L) (stabilized with H2SO4)
    Rabbit LD50 (dermal) 5 mg/kg
    Mouse LD50 (intraperitoneal) 3
    mg/kg

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Section III. Hazards Identification
    Acute Health Effects        Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.    
    Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
    eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
    occasionally, blistering.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
    Chronic Health Effects        CARCINOGENIC EFFECTS : Not available.    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or
    many human organs.

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Section IV.        First Aid Measures    
    Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
    Eye Contact
    minutes. Get medical attention.
    In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
    Skin Contact
    before reuse. Thoroughly clean shoes before reuse. Get medical attention.
    Inhalation        If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or    
    waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
    improve.
    Ingestion        INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.    
    Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
    resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
    material was ingested; the absence of such signs, however, is not conclusive.

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Section V.        Fire and Explosion Data    
    Not available.
    Combustible.        Auto-Ignition    
    Flammability
    Flammable Limits        Not available.    
    Flash Points        69°C (156.2°F)    
    Combustion Products        These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2).    
    WARNING: Very toxic cyanide gas may be produced in a fire. Do not inhale.
    Fire Hazards        Not available.    
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards
    Risks of explosion of the product in presence of static discharge: Not available.
    Fire Fighting Media        SMALL FIRE: Use DRY chemical powder.    
    and Instructions        LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.    
    Consult with local fire authorities before attempting large scale fire-fighting operations.
    Continued on Next Page
    Glycolonitrile
    (ca. 52% in Water, ca. 9.7mol/L) (stabilized with H2SO4)

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Section VI.        Accidental Release Measures    
    Spill Cleanup        Highly toxic material. Combustible material. Irritating material. Lachrymatory material.    
    Keep away from heat. Mechanical exhaust required. Stop leak if without risk. DO NOT get water inside container. DO NOT
    Instructions
    touch spilled material. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if
    needed. Consult federal, state, and/or local authorities for assistance on disposal.

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Section VII. Handling and Storage
    Handling and Storage        HIGHLY TOXIC. COMBUSTIBLE. IRRITANT. LACHRYMATORY. Keep locked up. Keep away from heat. Mechanical    
    exhaust required. Avoid excessive heat and light. DO NOT ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable
    Information
    protective clothing. If ingested, seek medical advice immediately and show the container or the label. Treat symptomatically
    and supportively.
    Always store away from incompatible compounds such as oxidizing agents.

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Section VIII. Exposure Controls/Personal Protection
    Engineering Controls        Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective    
    threshold limit value. Ensure that eyewash station and safety shower is proximal to the work-station location.
    Personal Protection        Splash goggles. Lab coat. Vapor respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a    
    specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
    Exposure Limits        Not available.    

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Section IX. Physical and Chemical Properties
    Physical state @ 20°C        Liquid. (Clear, colorless.)        Solubility        Not available.    
    1.07 (water=1)
    Specific Gravity
    Molecular Weight        57.05        Partition Coefficient        Not available.    
    Boiling Point        183°C (361.4°F)        Vapor Pressure        Not available.    
    Melting Point        -67°C (-88.6°F)        Vapor Density        Not available.    
    Not available.        Not available.    
    Refractive Index        Volatility    
    Critical Temperature        Not available.        Odor        Not available.    
    Not available.        Not available.    
    Viscosity        Taste    

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Section X.        Stability and Reactivity Data    
    Stability    

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This material is stable if stored under proper conditions. (See Section VII for instructions)    
    Conditions of Instability        Avoid excessive heat and light.    
    Incompatibilities        Reactive with oxidizing agents.    

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Section XI. Toxicological Information
    RTECS Number        AM0350000    
    Eye Contact. Ingestion. Inhalation.
    Routes of Exposure
    Rat LD50 (oral) 8 mg/kg
    Toxicity Data
    Rabbit LD50 (dermal) 5 mg/kg
    Mouse LD50 (intraperitoneal) 3 mg/kg
    Chronic Toxic Effects        CARCINOGENIC EFFECTS : Not available.    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many
    human organs.
    Acute Toxic Effects        Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.    
    Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye
    is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
    occasionally, blistering.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
    Continued on Next Page
    Glycolonitrile
    (ca. 52% in Water, ca. 9.7mol/L) (stabilized with H2SO4)

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Section XII.        Ecological Information    
    Ecotoxicity        Not available.    
    Glycolonitrile's production and use as solvent and organic intermediate may result in its release to the environment through
    Environmental Fate
    various waste streams. If released to air, an estimated vapor pressure of 0.8 mm Hg at 25 deg C indicates glycolonitrile will
    exist solely as a vapor. Vapor-phase glycolonitrile will be degraded in the atmosphere by reaction with
    photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 21 days. If released to soil,
    glycolonitrile is expected to have very high mobility based upon an estimated Koc of 1. Volatilization from moist soil surfaces
    is not expected to be an important fate process based upon an estimated Henry's Law constant of 7.4X10-6 atm-cu m/mole.
    Glycolonitrile is not expected to volatilize from dry soil surfaces based upon its vapor pressure. If released into water,
    glycolonitrile is not expected to adsorb to suspended solids and sediment in water based upon the estimated Koc.
    Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated
    Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 61 hrs and 30 days,
    respectively. An estimated BCF of 0.5 suggests the potential for bioconcentration in aquatic organisms is low. Occupational
    exposure to glycolonitrile may occur through inhalation and dermal contact with this compound at workplaces where
    glycolonitrile is produced or used.

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Section XIII. Disposal Considerations
    Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
    Waste Disposal
    combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
    federal, state and local regulations when disposing of the substance.

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Section XIV. Transport Information
    DOT CLASS 6.1: Toxic material
    DOT Classification
    PIN Number
    Proper Shipping Name        Nitriles, toxic, liquid, n.o.s.    
    Packing Group (PG)        I    
    DOT Pictograms

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Section XV. Other Regulatory Information and Pictograms
    TSCA Chemical Inventory        This compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list.    
    (EPA)
    WHMIS Classification        CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F).    
    CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
    (Canada)
    On NDSL.
    EINECS Number (EEC) 203-469-1
    EEC Risk Statements
    R26/27/28- Very toxic by inhalation, in contact with skin and if swallowed.
    R36/37/38- Irritating to eyes, respiratory system and skin.

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SECTION 16 - ADDITIONAL INFORMATION
N/A