112101-81-2 (R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺,(R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide)

快速询单

结构式：

R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺MOL文件

CAS号：

112101-81-2

中文名称：

R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺

英文名称：

(R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide

分子式：

C₁₀H₁₆N₂O₃S

分子量：

244.310641288757

API：

Tamsulosin

R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺(112101-81-2)名称与标识符

名称

中文别名：

R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺;5-[(2R)-2-氨基丙基]-2-甲氧基苯磺酰胺;5-(2-氨基丙基)-2-甲氧基苯磺酰胺;5-[(2R)-2-氨基丙基]-2-甲氧基苯;R-(-)5-[2(2-氨基-2-甲基)乙基]-2-甲氧基苯基磺酰胺;盐酸坦索罗辛杂质B(EP) 标准品;盐酸坦索罗辛杂质B;坦索罗辛中间体;

英文别名：

5-[(2R)-2-Aminopropyl]-2-methoxy benzene sulfonamide;r-(-)-5-(2-amino-propyl)-2-methoxy-benzenesulfonamide;5-[(2R)-2Aminopropyl]-2-methoxy benzene sulfonamide;R-(-)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide;R-(-)-5-[2(2-amino-2-methyl)ethyl]-2-methoxybenzenesulfonamide;(2R)-2-amino-1-(4-methoxy-3-sulfamoylphenyl)propane;(R)-1-methyl-2-(3-aminosulfonyl-4-methoxyphenyl)ethylamine;(R)-5-(2-aminopropyl)-2-meth;5-[(2R)2-2Aminopropyl]-2-MethoxyBenzeneSulfonamide;5-[(R)-(2-aminopropyl)]-2-methoxybenzene;R(-)-5-[(2-amino-2-methyl)ethyl]-2-methoxy benzenesulfonamide;R-(-)-5-2(2-AMinopropyl)-2-MethoxybenzenesulfonaMide;Benzenesulfonamide,5-(2-aminopropyl)-2-methoxy-, (R)-;(R)-(-)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide;(R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide;Benzenesulfonamide,5-[(2R)-2-aminopropyl]-2-methoxy-;5-[(2R)-2-AMINOPROPYL]-2-METHOXYBENZENESULFONAMIDE;(r)-5-(2-aminopropyl)-2-methoxy benzene sulfonamide;5-[(R)-(2-AMINOPROPYL)]-2-METHOXYBENZENESULFONAMIDE HYDROCH;Benzenesulfonamide, 5-((2R)-2-aminopropyl)-2-methoxy-;AKOS015900167;DS-0700;67X36A2XME;MFCD07782137;Tamsulosin hydrochloride impurity B [EP];IORITYIZDHJCGT-SSDOTTSWSA-N;R-(-)-5-(2-Amino-propyl)-2-methoxybenzenesulfonamide;5-(2-aminopropyl)-2-methoxybenzene-1-sulfonamide;(R)-(-)-5-(2-Aminopropyl)-2-methoxy-benzenesulfonamide;SCHEMBL1412238;Benzenesulfonamide, 5-(2-aminopropyl)-2-methoxy-, (R)-;J-524215;Tamsulosin Hydrochloride Imp. B (EP); Tamsulosin Imp. B (EP); 5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide; Tamsulosin Hydrochloride Impurity B; Tamsulosin Impurity B;AMY25472;TAMSULOSIN HYDROCHLORIDE IMPURITY B [EP IMPURITY];R-(-)-5-[2(2-Amino-2-methyl)ethyl]-2-methoxybenzene sulfonamide;R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide;112101-81-2;A2233;5-[(2R)-2-aminopropyl]-2-methoxybenzene-1-sulfonamide;UNII-67X36A2XME;DTXSID10920664;Tamsulosin Hydrochloride Imp. B;TAMSULOSIN HYDROCHLORIDE IMPURITY B (EP IMPURITY);FA140744;Tamsulosin hydrochloride impurity B;601-159-4;

标识符

MDL：

MFCD07782137

InChIKey：

IORITYIZDHJCGT-SSDOTTSWSA-N

Inchi：

1S/C10H16N2O3S/c1-7(11)5-8-3-4-9(15-2)10(6-8)16(12,13)14/h3-4,6-7H,5,11H2,1-2H3,(H2,12,13,14)/t7-/m1/s1

SMILES：

S(C1=C(C=CC(=C1)C[C@@H](C)N)OC)(N)(=O)=O

R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺(112101-81-2)物化性质

实验特性

LogP : 2.04700
PSA : 98.00000
折射率 : 1.543
沸点 : 444.618°C at 760 mmHg
熔点 : 276-278°C
闪点 : 222.697°C
密度 : 1.288

计算特性

精确分子量 : 245.07200
氢键供体数量 : 2
氢键受体数量 : 5
可旋转化学键数量 : 4
同位素质量 : 244.08816355g/mol
重原子数量 : 16
复杂度 : 313
同位素原子数量 : 0
确定原子立构中心数量 : 1
不确定原子立构中心数量 : 0
确定化学键立构中心数量 : 0
不确定化学键立构中心数量 : 0
共价键单元数量 : 1
疏水参数计算参考值（XlogP） : 0.2
拓扑分子极性表面积 : 104

R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺(112101-81-2)海关数据

海关编码：

2935009090

海关数据：

中国海关编码：

2935009090

概述：

2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

申报要素：

品名, 成分含量, 用途

Summary：

2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺(112101-81-2)上下游

1,2-Propanediol, 1-(4-methoxyphenyl)-, (1R,2S)- 2Acetamide, N-[(1R) -2 - [3 - (aminosulfonyl)-4-methoxyphenyl]-1-methylethyl] - 5-(2-氨基丙基)-2-甲氧基苯磺酰胺 5-丙酮基-2-甲氧基苯磺酰胺 4-甲氧基苯甲醛 Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-,(1R,4S)-, compd. with5-[(2R)-2-aminopropyl]-2-methoxybenzenesulfonamide (1:1)

R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺(112101-81-2)参考资料

Beilstein：

R189713

PubChem CID：

10060387

R-(-)-5-(2-氨基丙基)-2-甲氧基苯磺酰胺(112101-81-2) MSDS

基础信息

Name:	(R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide Material Safety Data Sheet
Synonym:
CAS:	112101-81-2

Section 1 - Chemical Product ? MSDS Name:(R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
112101-81-2	(R)-5-(2-Aminopropyl)-2-methoxybenzene		unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
? EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
? Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
? General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
? General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
? Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
? Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 112101-81-2: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
?
Physical State: Solid
Color: white to light yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 168 - 172 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C10H16N2O3S
Molecular Weight: 244.31

Section 10 - STABILITY AND REACTIVITY
? Chemical Stability:
Not available.
Conditions to Avoid:
Not available.
Incompatibilities with Other Materials:
Not available.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
? RTECS#:
CAS# 112101-81-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
(R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION
?

Section 13 - DISPOSAL CONSIDERATIONS
? Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
?
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION
?
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 112101-81-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 112101-81-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 112101-81-2 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A