1217267-66-7

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结构式：

1217267-66-7MOL文件

CAS号：

1217267-66-7

1217267-66-7(1217267-66-7)名称与标识符

1217267-66-7(1217267-66-7)合成路线

合成路线：1 步

884603-33-2

1217267-66-7

884600-68-4

参考文献：

Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis

Nugent, Thomas C.; et al, Chemistry - A European Journal, 2016, 22(40), 14342-14348

合成路线：2 步

1996657-20-5

1217267-66-7

884600-68-4

反应条件：

1.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; cooled; 1 h, cooled
1.2 Reagents: Sodium bicarbonate Solvents: Water ; cooled
1.3 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 14 h, 7 bar, 25 °C
2.1 -

参考文献：

Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis

Nugent, Thomas C.; et al, Chemistry - A European Journal, 2016, 22(40), 14342-14348

合成路线：2 步

1996657-21-6

1217267-66-7

884600-68-4

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 14 h, 7 bar, 25 °C
2.1 -

参考文献：

Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis

Nugent, Thomas C.; et al, Chemistry - A European Journal, 2016, 22(40), 14342-14348

合成路线：3 步

反应条件：

1.1 Reagents: Lead tetraacetate Solvents: tert-Butanol ; 5 min, 25 °C; 45 min, 78 °C
2.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; cooled; 1 h, cooled
2.2 Reagents: Sodium bicarbonate Solvents: Water ; cooled
2.3 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 14 h, 7 bar, 25 °C
3.1 -

参考文献：

Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis

Nugent, Thomas C.; et al, Chemistry - A European Journal, 2016, 22(40), 14342-14348

合成路线：4 步

反应条件：

1.1 Reagents: 4-(Trifluoromethyl)benzoic acid Solvents: Diethyl ether , Methanol ; 5 min, cooled; 2 h, cooled
2.1 Reagents: Lead tetraacetate Solvents: tert-Butanol ; 5 min, 25 °C; 45 min, 78 °C
3.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; cooled; 1 h, cooled
3.2 Reagents: Sodium bicarbonate Solvents: Water ; cooled
3.3 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 14 h, 7 bar, 25 °C
4.1 -

参考文献：

Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis

Nugent, Thomas C.; et al, Chemistry - A European Journal, 2016, 22(40), 14342-14348

合成路线：5 步

1996657-06-7

1217267-66-7

884600-68-4

反应条件：

1.1 Reagents: Ammonium hydroxide Solvents: Acetonitrile , Water ; 1 min, 25 °C; 1 h, 25 °C
1.2 Reagents: Sodium periodate Catalysts: Ruthenium trichloride Solvents: Carbon tetrachloride , Acetonitrile , Water ; 14 h, 25 °C
2.1 Reagents: 4-(Trifluoromethyl)benzoic acid Solvents: Diethyl ether , Methanol ; 5 min, cooled; 2 h, cooled
3.1 Reagents: Lead tetraacetate Solvents: tert-Butanol ; 5 min, 25 °C; 45 min, 78 °C
4.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; cooled; 1 h, cooled
4.2 Reagents: Sodium bicarbonate Solvents: Water ; cooled
4.3 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 14 h, 7 bar, 25 °C
5.1 -

参考文献：

Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis

Nugent, Thomas C.; et al, Chemistry - A European Journal, 2016, 22(40), 14342-14348

合成路线：5 步

1996657-17-0

1217267-66-7

884600-68-4

反应条件：

1.1 Reagents: Sodium periodate Catalysts: Ruthenium trichloride Solvents: Carbon tetrachloride , Acetonitrile , Water ; 14 h, 25 °C
2.1 Reagents: 4-(Trifluoromethyl)benzoic acid Solvents: Diethyl ether , Methanol ; 5 min, cooled; 2 h, cooled
3.1 Reagents: Lead tetraacetate Solvents: tert-Butanol ; 5 min, 25 °C; 45 min, 78 °C
4.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; cooled; 1 h, cooled
4.2 Reagents: Sodium bicarbonate Solvents: Water ; cooled
4.3 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 14 h, 7 bar, 25 °C
5.1 -

参考文献：

Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis

Nugent, Thomas C.; et al, Chemistry - A European Journal, 2016, 22(40), 14342-14348

合成路线：6 步

反应条件：

1.1 Catalysts: (4R)-4-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-L-proline Solvents: Water ; 44 h, 25 °C
1.2 Reagents: m-Chloroperbenzoic acid Solvents: Dichloromethane , Water ; 5 min, 25 °C; 9 h, 25 °C
1.3 Reagents: Sodium sulfite Solvents: Water
2.1 Reagents: Ammonium hydroxide Solvents: Acetonitrile , Water ; 1 min, 25 °C; 1 h, 25 °C
2.2 Reagents: Sodium periodate Catalysts: Ruthenium trichloride Solvents: Carbon tetrachloride , Acetonitrile , Water ; 14 h, 25 °C
3.1 Reagents: 4-(Trifluoromethyl)benzoic acid Solvents: Diethyl ether , Methanol ; 5 min, cooled; 2 h, cooled
4.1 Reagents: Lead tetraacetate Solvents: tert-Butanol ; 5 min, 25 °C; 45 min, 78 °C
5.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; cooled; 1 h, cooled
5.2 Reagents: Sodium bicarbonate Solvents: Water ; cooled
5.3 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 14 h, 7 bar, 25 °C
6.1 -

参考文献：

Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis

Nugent, Thomas C.; et al, Chemistry - A European Journal, 2016, 22(40), 14342-14348

合成路线：6 步

1996656-90-6

1217267-66-7

884600-68-4

反应条件：

1.1 Reagents: m-Chloroperbenzoic acid Solvents: Dichloromethane , Water ; 5 min, 25 °C; 9 h, 25 °C
1.2 Reagents: Sodium sulfite Solvents: Water
2.1 Reagents: Ammonium hydroxide Solvents: Acetonitrile , Water ; 1 min, 25 °C; 1 h, 25 °C
2.2 Reagents: Sodium periodate Catalysts: Ruthenium trichloride Solvents: Carbon tetrachloride , Acetonitrile , Water ; 14 h, 25 °C
3.1 Reagents: 4-(Trifluoromethyl)benzoic acid Solvents: Diethyl ether , Methanol ; 5 min, cooled; 2 h, cooled
4.1 Reagents: Lead tetraacetate Solvents: tert-Butanol ; 5 min, 25 °C; 45 min, 78 °C
5.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; cooled; 1 h, cooled
5.2 Reagents: Sodium bicarbonate Solvents: Water ; cooled
5.3 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 14 h, 7 bar, 25 °C
6.1 -

参考文献：

Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis

Nugent, Thomas C.; et al, Chemistry - A European Journal, 2016, 22(40), 14342-14348

合成路线：7 步

1996656-75-7

1217267-66-7

884600-68-4

反应条件：

1.1 Catalysts: p-Toluenesulfonic acid Solvents: Acetone , Water ; 10 h, 55 °C; 55 °C → 25 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ; 15 min, 25 °C
2.1 Catalysts: (4R)-4-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-L-proline Solvents: Water ; 44 h, 25 °C
2.2 Reagents: m-Chloroperbenzoic acid Solvents: Dichloromethane , Water ; 5 min, 25 °C; 9 h, 25 °C
2.3 Reagents: Sodium sulfite Solvents: Water
3.1 Reagents: Ammonium hydroxide Solvents: Acetonitrile , Water ; 1 min, 25 °C; 1 h, 25 °C
3.2 Reagents: Sodium periodate Catalysts: Ruthenium trichloride Solvents: Carbon tetrachloride , Acetonitrile , Water ; 14 h, 25 °C
4.1 Reagents: 4-(Trifluoromethyl)benzoic acid Solvents: Diethyl ether , Methanol ; 5 min, cooled; 2 h, cooled
5.1 Reagents: Lead tetraacetate Solvents: tert-Butanol ; 5 min, 25 °C; 45 min, 78 °C
6.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; cooled; 1 h, cooled
6.2 Reagents: Sodium bicarbonate Solvents: Water ; cooled
6.3 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 14 h, 7 bar, 25 °C
7.1 -

参考文献：

Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis

Nugent, Thomas C.; et al, Chemistry - A European Journal, 2016, 22(40), 14342-14348

合成路线：8 步

反应条件：

1.1 Reagents: Butyllithium Solvents: Diethyl ether , Hexane ; 15 min, -60 °C; -60 °C → -78 °C
1.2 Solvents: Diethyl ether ; 10 min, -78 °C; 4 h, -78 °C
1.3 Reagents: Water ; -78 °C
2.1 Catalysts: p-Toluenesulfonic acid Solvents: Acetone , Water ; 10 h, 55 °C; 55 °C → 25 °C
2.2 Reagents: Sodium bicarbonate Solvents: Water ; 15 min, 25 °C
3.1 Catalysts: (4R)-4-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-L-proline Solvents: Water ; 44 h, 25 °C
3.2 Reagents: m-Chloroperbenzoic acid Solvents: Dichloromethane , Water ; 5 min, 25 °C; 9 h, 25 °C
3.3 Reagents: Sodium sulfite Solvents: Water
4.1 Reagents: Ammonium hydroxide Solvents: Acetonitrile , Water ; 1 min, 25 °C; 1 h, 25 °C
4.2 Reagents: Sodium periodate Catalysts: Ruthenium trichloride Solvents: Carbon tetrachloride , Acetonitrile , Water ; 14 h, 25 °C
5.1 Reagents: 4-(Trifluoromethyl)benzoic acid Solvents: Diethyl ether , Methanol ; 5 min, cooled; 2 h, cooled
6.1 Reagents: Lead tetraacetate Solvents: tert-Butanol ; 5 min, 25 °C; 45 min, 78 °C
7.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; cooled; 1 h, cooled
7.2 Reagents: Sodium bicarbonate Solvents: Water ; cooled
7.3 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 14 h, 7 bar, 25 °C
8.1 -

参考文献：

Beyond Chemoselectivity: Catalytic Site-Selective Aldolization of Diketones and Exploitation for Enantioselective Alzheimer's Drug Candidate Synthesis

Nugent, Thomas C.; et al, Chemistry - A European Journal, 2016, 22(40), 14342-14348

80775-42-4(1-(5-溴噻吩-2-基)-3-氯丙烷-1-酮) 81462-07-9(4-phenyloxan-4-ol) 81562-78-9(八氢异喹啉-4alpha-醇) 81574-69-8(2-溴-4,6-二甲氧基苯甲醛) 81560-06-7(5-溴-3-甲基-2-(甲基硫代)嘧啶-4(3H)-酮) 81568-09-4(5-Chloro-2-dimethylaminopyrimidine) 816448-94-9(6-METHYLQUINOLINE-4-CARBOXYLIC ACID) 81540-86-5((8Z,11Z,14Z)-(8,9,11,12,14,15-2H6)-8,11,14-Icosatrienoic acid)

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1217267-66-7

1217267-66-7(1217267-66-7)名称与标识符

1217267-66-7(1217267-66-7)合成路线

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