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127045-37-8 (帕珠沙星,7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-)

结构式：

帕珠沙星结构式图片|127045-37-8结构式图片

帕珠沙星MOL文件

CAS号：

127045-37-8

中文名称：

帕珠沙星

英文名称：

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-

分子式：

C₁₆H₁₅FN₂O₄

分子量：

318.299707651138

相关分类：

溶剂及有机化学品 > 有机化合物 > Organoheterocyclic compounds > Quinolines and derivatives > Quinoline carboxylic acids

帕珠沙星(127045-37-8)名称与标识符

名称

中文别名：

帕珠沙星;

英文别名：

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dih...;PAZUFLOXACIN;CHEBI:182880;HMS3393B05;(1-aminocyclopropyl)-fluoro-methyl-oxo-[?]carboxylic acid;10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-;127045-37-8;10-(1-Aminocyclopropyl)-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylicacid;SCHEMBL8386358;6-(1-aminocyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-;DTXSID60861290;6-(1-aminocyclopropyl)-7-luoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;(-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7--oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid;10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;Pazufloxacin, (RS)-;6-(1-Aminocyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;94GQS5V55L;FT-0631124;127046-18-8;T3761;

标识符

InChIKey：

XAGMUUZPGZWTRP-UHFFFAOYSA-N

Inchi：

1S/C16H15FN2O4/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22/h4-5,7H,2-3,6,18H2,1H3,(H,21,22)

SMILES：

FC1C=C2C(C(C(=O)O)=CN3C(C)COC(=C32)C=1C1(CC1)N)=O

帕珠沙星(127045-37-8)物化性质

实验特性

PSA : 92.86
沸点 : 531.5 °C at 760 mmHg
熔点 : 269-271°C
闪点 : 275.2 °C
密度 : 1.56

计算特性

精确分子量 : 318.10165
氢键供体数量 : 2
氢键受体数量 : 7
可旋转化学键数量 : 2
同位素质量 : 318.101585
重原子数量 : 23
复杂度 : 603
同位素原子数量 : 0
确定原子立构中心数量 : 0
不确定原子立构中心数量 : 1
确定化学键立构中心数量 : 0
不确定化学键立构中心数量 : 0
共价键单元数量 : 1
疏水参数计算参考值（XlogP） : -0.8
拓扑分子极性表面积 : 92.9

帕珠沙星(127045-37-8)相关文献

1. Determination of sarafloxacin and its analogues in milk using an enzyme-linked immunosorbent assay based on a monoclonal antibody
B. N. Tochi,Juan Peng,Shanshan Song,Liqiang Liu,Hua Kuang,Chuanlai Xu Anal. Methods 2016 8 1626
2. Fluorescent strip sensor for rapid and ultrasensitive determination of fluoroquinolones in fish and milk
Xianlu Lei,Lingling Guo,Liguang Xu,Hua Kuang,Chuanlai Xu,Liqiang Liu Analyst 2023 148 381
3. Recognition of quinolone antibiotics by the multidrug efflux transporter MexB of Pseudomonas aeruginosa
Silvia Gervasoni,Giuliano Malloci,Andrea Bosin,Attilio V. Vargiu,Helen I. Zgurskaya,Paolo Ruggerone Phys. Chem. Chem. Phys. 2022 24 16566
4. Water-compatible molecularly imprinted polymers prepared using metal–organic gel as porogen
Li Ma,Lei Tang,Rong-Shan Li,Yan-Ping Huang,Zhao-Sheng Liu RSC Adv. 2015 5 84601
5. Molecularly imprinted polymer-based solid phase extraction combined high performance liquid chromatography for determination of fluoroquinolones in milk
Geng Nan Wang,Kun Yang,Hui Zhi Liu,Meng Xiao Feng,Jian Ping Wang Anal. Methods 2016 8 5511
6. Semi-targeted residue screening in complex matrices with liquid chromatography coupled to high resolution mass spectrometry: current possibilities and limitations
Anton Kaufmann,Patrick Butcher,Kathryn Maden,Stephan Walker,Miryam Widmer Analyst 2011 136 1898
7. Stereospecific recognition and quantitative structure–activity relationship between antibodies and enantiomers: ofloxacin as a model hapten
Hongtao Mu,Baoling Wang,Zhenlin Xu,Yuanming Sun,Xinan Huang,Yudong Shen,Sergei A. Eremin,Anatoly V. Zherdev,Boris B. Dzantiev,Hongtao Lei Analyst 2015 140 1037
8. CO2-fixation into cyclic and polymeric carbonates: principles and applications
Aeilke J. Kamphuis,Francesco Picchioni,Paolo P. Pescarmona Green Chem. 2019 21 406
9. Enhanced fluorescence detection of enrofloxacin with curved-surface responsive inverse opal polymers and molecular imprinting
Zhenhe Chen,Jianling Sun,Yong He,Tingting Zhang,Run Hao,Aijun Shi,Eduardo Enciso Anal. Methods 2019 11 1043
10. Simultaneous and differential determination of drugs and metabolites using the same antibody: difloxacin and sarafloxacin case
M. A. Burkin,I. A. Galvidis Anal. Methods 2016 8 5843

目录

相关化合物

127045-41-4(帕珠沙星) 176760-98-8((S)-10-氰甲基-9-氟-2,3-二氢-3-甲基-7-氧代-7H-吡啶并[1,2,3-de]-1,4-苯并恶嗪-6-羧酸) 136905-87-8(甲磺酸帕苏沙星) 80904-75-2(3-(hydroxymethyl)-2H-furan-5-one) 81059-04-3(3-[(2-tert-butyl-5-methoxy-1,3-benzothiazol-6-yl)carbamothioylsulfanyl]propanoic acid) 81882-18-0(1-benzofuran-2-ylmethanamine;hydrochloride) 81720-06-1([(1aS,1bα,5aα,6aβ)-2α-(β-D-Glucopyranosyloxy)-1a,1b,2,5a,6,6a-hexahydro-1aβ-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-6α-yl]α-D-galactopyranoside) 81840-57-5(（1E）-1-（4-羟基-3-甲氧基苯基）-7-苯基庚-1-烯-3-酮)

相关产品厂家

ent-甲磺酸帕珠沙星厂家 ent-甲磺酸帕珠沙星厂家 ent-帕珠沙星甲磺酸酯厂家 Pazufloxacin Mesylate 甲磺酸帕珠沙星厂家甲磺酸帕珠沙星厂家甲磺酸帕珠沙星厂家甲磺酸帕珠沙星厂家帕珠沙星厂家帕珠沙星厂家帕珠沙星厂家帕珠沙星厂家帕珠沙星（碱基料）厂家帕珠沙星单盐酸盐厂家帕珠沙星甲磺酸酯厂家帕珠沙星脱羧水解物厂家帕珠沙星中间体厂家帕珠沙星中间体II厂家帕珠沙星中间体二厂家

资讯

肝癌治疗新适应证！“K药”帕博利珠单抗在华获，用于既往接受过索拉非尼或含奥沙利铂化疗的肝细胞癌（HCC）患者

问答

960化工网为您提供帕珠沙星专业化合物百科信息，包括中文名，英文名，分子式，分子量，以及该化合物的CasNo.127045-37-8,相关理化性质;并提供了优质生产厂家信息包括厂家名称和联系方式等。 WAP版:127045-37-8 国际站:127045-37-8

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