1421502-62-6 (PF-06263276,PF-06263276)

CAS号:
1421502-62-6
中文名称:
PF-06263276
英文名称:
PF-06263276
分子式:
C31H31FN8O2
分子量:
566.6286
简介:
PF-06263276 (PF 6263276) 是一种有效、选择性的 pan-JAK 抑制剂,对 JAK1、JAK2、JAK3 和 TYK2 的抑制作用 IC50 值分别为 2.2 nM、23.1 nM、59.9 nM 和 29.7 nM。

PF-06263276(1421502-62-6)名称与标识符

名称

英文别名:
{2-[6-(2-Ethyl-5-Fluoro-4-Hydroxyphenyl)-2h-Indazol-3-Yl]-3,4,6,7-Tetrahydro-5h-Imidazo[4,5-C]pyridin-5-Yl}[5-(Piperidin-1-Yl)pyrazin-2-Yl]methanone;86YZ7HCC8V;GTPL9432;compound 2 [PMID: 27983835];PF0626327;PF 0626327;J3.613.306F;(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-6,7-dihydro-3H-imidazo(4,5-C)pyridin-5(4H)-yl)(5-(piperidin-1;[2-[6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-;PF-06263276;2-[6-(2-Ethyl-5- fl uoro-4-hydroxyphenyl)-1 H -indazol-3-yl]- 1,4,6,7-tetrahydroimidazo[4,5- c ]pyridin-5-yl-(5-piperidin-1-yl- pyrazin-2-yl)methanone;[2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(5-piperidin-1-ylpyrazin-2-yl)methanone;DA-76770;SCHEMBL14658676;PF-06263276, >=98% (HPLC);7GS;compound 2 (PMID: 27983835);1421502-62-6;SCHEMBL20767494;2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-1,4,6,7-tetrahydroimidazo(4,5-c)pyridin-5-yl-(5-piperidin-1-yl-pyrazin-2-yl)methanone;HY-101024;2-(6-(2-Ethyl-5-fl uoro-4-hydroxyphenyl)-1 H-indazol-3-yl)-1,4,6,7-tetrahydroimidazo(4,5-c)pyridin-5-yl-(5-piperidin-1-yl-pyrazin-2-yl)methanone;SCHEMBL24377559;UNII-86YZ7HCC8V;(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-6,7-dihydro-3H-imidazo(4,5-C)pyridin-5(4H)-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone;2-[6-(2-Ethyl-5-fl uoro-4-hydroxyphenyl)-1 H-indazol-3-yl]-1,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl-(5-piperidin-1-yl-pyrazin-2-yl)methanone;AKOS040742397;CHEMBL3644620;(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1h-indazol-3-yl)-3,4,6,7-tetrahydro-5h-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone;[2-[6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(1-piperidinyl)-2-pyrazinyl]-methanone;GLXC-10185;Methanone, (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo(4,5-C)pyridin-5-yl)(5-(1-piperidinyl)-2-pyrazinyl)-;MS-30258;WGC50262;CS-0020732;PF06263276;

标识符

InChIKey:
XDJGNPSZQSWJCV-UHFFFAOYSA-N
Inchi:
1S/C31H31FN8O2/c1-2-18-13-27(41)22(32)14-21(18)19-6-7-20-24(12-19)37-38-29(20)30-35-23-8-11-40(17-26(23)36-30)31(42)25-15-34-28(16-33-25)39-9-4-3-5-10-39/h6-7,12-16,41H,2-5,8-11,17H2,1H3,(H,35,36)(H,37,38)
SMILES:
FC1=C(C([H])=C(C([H])([H])C([H])([H])[H])C(=C1[H])C1C([H])=C([H])C2=C(C=1[H])N([H])N=C2C1=NC2=C(C([H])([H])N(C(C3=C([H])N=C(C([H])=N3)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=O)C([H])([H])C2([H])[H])N1[H])O[H]

PF-06263276(1421502-62-6)物化性质

计算特性

  • 精确分子量 : 566.25540042g/mol
  • 氢键供体数量 : 3
  • 氢键受体数量 : 8
  • 可旋转化学键数量 : 5
  • 同位素质量 : 566.25540042g/mol
  • 重原子数量 : 42
  • 复杂度 : 941
  • 同位素原子数量 : 0
  • 确定原子立构中心数量 : 0
  • 不确定原子立构中心数量 : 0
  • 确定化学键立构中心数量 : 0
  • 不确定化学键立构中心数量 : 0
  • 共价键单元数量 : 1
  • 疏水参数计算参考值(XlogP) : 4.1
  • 拓扑分子极性表面积 : 127

PF-06263276(1421502-62-6)安全信息

PF-06263276(1421502-62-6)推荐厂家 更多厂家(3)

公司名称手机号/电话联系人QQ微信询单
MedChemExpress(MCE 中国) 13611715263
021-58955995
MCE生命科学试剂 2881321772
询单
MedChemExpress(MCE 中国) 13611715263
021-58955995
MCE生命科学试剂 2881321772
询单
上海源溪生物科技有限公司 13564518121李经理 1724405207 询单