14996-02-2 ((Sulfate, hydrogen(8CI,9CI))

反应条件：

1.1 Solvents: Methanol , Water ; 60 - 80 min, 0 - 5 °C

参考文献：

A process for the preparation of isavuconazonium sulfate

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Sodium bisulfate Solvents: Dichloromethane , Water ; 0.5 - 1 h, 0 - 10 °C

参考文献：

Preparation of isavuconazonium sulfate

, World Intellectual Property Organization, , ,

合成路线：1 步

338990-64-0

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Ethanol , Water ; 2 h, rt

参考文献：

Preparation of isavuconazole sulfate

, China, , ,

合成路线：1 步

741241-71-4

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Ethyl acetate , Water ; 0 - 10 °C; 10 °C → 30 °C; 2 h, 30 °C

参考文献：

Preparation of isavuconazonium monosulfate by bisulfate/sulfate anion exchange technology

, China, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Ethyl acetate , Water ; 0 - 10 °C; 0 °C → 60 °C; 2 h, 60 °C

参考文献：

Method for preparing isavuconazonium sulfate by oxidation-reduction reaction

, China, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Sodium iodide Solvents: Acetonitrile ; rt → 70 °C; 3 h, 70 °C
1.2 Reagents: Hydrochloric acid Solvents: Ethyl acetate ; rt; 2 h, rt
1.3 Reagents: Sodium bicarbonate Solvents: Dichloromethane , Water ; 0 °C; pH 6.5, < 5 °C
1.4 Solvents: Dichloromethane , Water ; 1 h, 15 °C

参考文献：

Method for preparing antifungal drug isavuconazonium sulfate

, China, , ,

合成路线：1 步

338990-63-9

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Ethyl acetate ; 25 - 30 °C

参考文献：

Process for the preparation of isavuconazonium sulfate

, India, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Sodium hydroxide , Hydrogen Catalysts: Palladium Solvents: Water ; rt; cooled
1.2 Reagents: Sulfuric acid Solvents: Water

参考文献：

Preparation of isavuconazonium sulfate

, China, , ,

合成路线：1 步

参考文献：

Crystalline form of isavuconazonium sulfate and a process for its preparation

, India, , ,

合成路线：1 步

参考文献：

Preparation of (2-(methylamino)pyridin-3-yl)methanol as intermediate for preparing isavuconazonium sulfate as antifungal agents

, China, , ,

合成路线：1 步

参考文献：

Preparation of isavuconazonium sulfate

, China, , ,

合成路线：1 步

参考文献：

Isavuconazonium salts and process for preparing thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

参考文献：

Preparation of isavuconazonium sulfate and intermediates thereof

, China, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Hydrogen peroxide Solvents: Methanol

参考文献：

Thiono compounds. 5. Preparation and oxidation of some thiono derivatives of imidazoles

Karkhanis, Dattatraya W.; Field, Lamar, Phosphorus and Sulfur and the Related Elements, 1985, 22(1), 49-57

合成路线：1 步

_100%

反应条件：

1.1 Solvents: Toluene ; 10 h, reflux; reflux → rt
1.2 Reagents: Sulfuric acid ; 0 - 2 °C; 40 °C

参考文献：

Ionic Liquids as Catalyst for Synthesis of Some Aromatic Peracetylated N-(β-D-Glucopyranosyl) Thiosemicarbazones

Thanh, Nguyen Dinh; et al, Current Organic Synthesis, 2016, 13(5), 767-774

合成路线：1 步

_100%

反应条件：

1.1 12 h, 80 °C
1.2 Reagents: Sulfuric acid Solvents: Water ; 6 h, 60 °C

参考文献：

Kinetics Study of the Ketalization Reaction of Cyclohexanone with Glycol Using Bronsted Acidic Ionic Liquids as Catalysts

Tao, Duan-Jian; et al, Industrial & Engineering Chemistry Research, 2012, 51(50), 16263-16269

合成路线：1 步

_99%

反应条件：

1.1 12 h, 80 °C
1.2 Reagents: Sulfuric acid Solvents: Water ; 12 h, 80 °C

参考文献：

Anionic SO3H-functionalized ionic liquid: An efficient and recyclable catalyst for the Pechmann reaction of phenols with ethyl acetoacetate

Song, Dayong; et al, Synthetic Communications, 2018, 48(6), 692-698

合成路线：1 步

179863-07-1

_100%

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Toluene ; rt; 24 h, 80 °C

参考文献：

Bronsted Acidic Ionic Liquid Catalyzed Three-Component Friedel-Crafts Reaction for the Synthesis of Unsymmetrical Triarylmethanes

Rinkam, Suttida; et al, Synlett, 2022, 33(14), 1383-1390

合成路线：1 步

179863-07-1

_99%

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Water ; 12 h, 60 °C

参考文献：

Groebke-Blackburn-Bienayme Multicomponent Reaction Catalysed by Reusable Bronsted acidic ionic Liquids

Anjos, Nicolas S.; et al, European Journal of Organic Chemistry, 2022, 2022(40),

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Water ; rt; 6 h, 80 °C

参考文献：

Reusable Task-Specific Ionic Liquids for a Clean ε-Caprolactam Synthesis under Mild Conditions

Turgis, Raphael; et al, ChemSusChem, 2010, 3(12), 1403-1408

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Sulfuric acid ; overnight, 60 °C

参考文献：

Pd-catalyzed ethylene methoxycarbonylation with Bronsted acid ionic liquids as promoter and phase-separable reaction media

Garcia-Suarez, Eduardo J.; et al, Green Chemistry, 2014, 16(1), 161-166

合成路线：1 步

65180-31-6

_50%

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Water ; 0 °C; 24 h, 50 °C

参考文献：

Polypyrrole nanocomposites doped with functional ionic liquids for high performance supercapacitors

Cao, Peng; et al, New Journal of Chemistry, 2018, 42(5), 3909-3916

合成路线：1 步

反应条件：

1.1 8 h, heated
1.2 Reagents: Sulfuric acid Solvents: Water ; 8 h, heated

参考文献：

Catalytic performance of acidic ionic liquids for esterification of α-methacrylic acid and stearyl alcohol

Peng, Jiani; et al, Shiyou Xuebao, 2016, 32(1), 193-200

合成路线：1 步

反应条件：

1.1 Solvents: Toluene ; 24 h, reflux
1.2 Reagents: Sulfuric acid Solvents: Water ; 24 h, 70 °C

参考文献：

Nanosilica-supported dual acidic ionic liquid as a heterogeneous and reusable catalyst for the synthesis of flavanones under solvent-free conditions

Rostamizadeh, Shahnaz; et al, Chemistry of Heterocyclic Compounds (New York, 2015, 51(6), 526-530

合成路线：1 步

反应条件：

1.1 Solvents: Toluene ; 3 h, 80 °C
1.2 Reagents: Sulfuric acid Solvents: Water ; 2 h, rt

参考文献：

Synthesis of tributyl citrate using acid ionic liquid as catalyst

Xu, Junming; et al, Process Safety and Environmental Protection, 2010, 88(1), 28-30

合成路线：1 步

反应条件：

1.1 12 h, 40 °C
1.2 Reagents: Sulfuric acid Solvents: Water ; rt; 6 h, 80 °C

参考文献：

Broensted acidic ionic liquids as novel catalysts for the hydrolyzation of soybean isoflavone glycosides

Yang, Qiwei; et al, Catalysis Communications, 2008, 9(6), 1307-1311

合成路线：1 步

反应条件：

1.1 Reagents: Tetraethoxysilane Solvents: Ethanol ; 10 min, rt; 1 w, rt; 3 w, rt
1.2 Solvents: Ethanol ; 2 h, reflux

参考文献：

Efficient synthesis of 4-phenacylideneflavenes using recyclable gelified Bronsted acidic ionic liquid under solvent-free and column chromatography-free conditions: a green method and mechanistic insight

Nguyen, Xuan-Trang T.; et al, Journal of Chemical Technology and Biotechnology, 2022, 97(3), 653-661

合成路线：2 步

反应条件：

1.1 0 °C; 12 h, rt
2.1 Reagents: Sulfuric acid Solvents: Water ; 0 °C; 24 h, 50 °C

参考文献：

Polypyrrole nanocomposites doped with functional ionic liquids for high performance supercapacitors

Cao, Peng; et al, New Journal of Chemistry, 2018, 42(5), 3909-3916

合成路线：2 步

179863-07-1

反应条件：

1.1 Reagents: Sulfuric acid ; 2 h
2.1 Reagents: Tetraethoxysilane Solvents: Ethanol ; 10 min, rt; 1 w, rt; 3 w, rt
2.2 Solvents: Ethanol ; 2 h, reflux

参考文献：

Nguyen, Xuan-Trang T.; et al, Journal of Chemical Technology and Biotechnology, 2022, 97(3), 653-661

合成路线：2 步

反应条件：

1.1 Solvents: Ethanol ; 2 d, heated
2.1 0 °C; 2 - 3 d, 50 °C
2.2 Reagents: Sulfuric acid ; 0 °C; 1 - 2 d, 50 °C

参考文献：

Synthesis of methylal from methanol and formaldehyde catalyzed by Bronsted acid ionic liquids with different alkyl groups

Sun, Jiahan; et al, RSC Advances, 2015, 5(106), 87200-87205

合成路线：3 步

反应条件：

1.1 Solvents: Ethanol ; 2 d
2.1 0 °C; 2 - 3 d, 50 °C
3.1 Reagents: Sulfuric acid ; 0 °C; 1 - 2 d, 50 °C

参考文献：

Synthesis of polyoxymethylene dimethyl ethers from methylal and trioxane catalyzed by Bronsted acid ionic liquids with different alkyl groups

Wu, Qin; et al, RSC Advances, 2015, 5(71), 57968-57974

合成路线：2 步

616-47-7

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Toluene ; 80 °C
2.1 Reagents: Sulfuric acid

参考文献：

A non-metal route to realize the bio-based polyester of poly(hexylene succinate): preparation conditions, side-reactions and mechanism in sulfonic acid-functionalized Bronsted acidic ionic liquids

Wei, Chenyang; et al, RSC Advances, 2020, 10(58), 35381-35388

合成路线：3 步

反应条件：

1.1 1 h, 80 °C
2.1 Reagents: Sulfuric acid ; 2 h
3.1 Reagents: Tetraethoxysilane Solvents: Ethanol ; 10 min, rt; 1 w, rt; 3 w, rt
3.2 Solvents: Ethanol ; 2 h, reflux

参考文献：

Nguyen, Xuan-Trang T.; et al, Journal of Chemical Technology and Biotechnology, 2022, 97(3), 653-661

合成路线：3 步

288-32-4

反应条件：

1.1 Reagents: Sodium ethoxide ; 8 h, heated
2.1 Solvents: Ethanol ; 2 d, heated
3.1 0 °C; 2 - 3 d, 50 °C
3.2 Reagents: Sulfuric acid ; 0 °C; 1 - 2 d, 50 °C

参考文献：

Synthesis of methylal from methanol and formaldehyde catalyzed by Bronsted acid ionic liquids with different alkyl groups

Sun, Jiahan; et al, RSC Advances, 2015, 5(106), 87200-87205

合成路线：4 步

288-32-4