1643462-64-9 (6-[4-(3-Trifluoromethylpyridin-2-yloxy)-2-methylphenyl]-1,5-dimethyl-2,4(1H,3H)-pyrimidinedione,(Rac)-Tavapadon)

CAS号:
1643462-64-9
中文名称:
6-[4-(3-Trifluoromethylpyridin-2-yloxy)-2-methylphenyl]-1,5-dimethyl-2,4(1H,3H)-pyrimidinedione
英文名称:
(Rac)-Tavapadon
分子式:
C19H16F3N3O3
分子量:
391.343854904175
简介:
(Rac)-Tavapadon ((Rac)-PF-06649751) 是有效的,选择性非儿茶酚多巴胺 D1 受体 (dopamine D1 receptor) 激动剂。(Rac)-Tavapadon 在 GS 激活试验中显示出强大的完全激动作用,在 β-arrestin2 募集试验中显示出部分激动作用 (GS-cAMP, EC50=0.8 nM; β-arrestin2, EC50=68 nM)。(Rac)-Tavapadon 具有抗帕金森病活性。

6-[4-(3-Trifluoromethylpyridin-2-yloxy)-2-methylphenyl]-1,5-dimethyl-2,4(1H,3H)-pyrimidinedione(1643462-64-9)名称与标识符

名称

英文别名:
(Rac)-Tavapadon;1,5-dimethyl-6-[2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]oxyphenyl]pyrimidine-2,4-dione;(Rac)-Tavapadon((Rac)-PF-06649751);Tavapadon;DA-67955;PF-06649751;GTPL13372;UNII-PT4P8MJP8L;CVL-751;1,5-dimethyl-6-(2-methyl-4-{[3-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-3H-pyrimidine-2,4-dione;AC-36997;AKOS040742684;D11431;CS-0131271;1,5-dimethyl-6-[2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]oxy-phenyl]pyrimidine-2,4-dione;AKQXQLUNFKDZBN-UHFFFAOYSA-N;1643462-64-9;BCP32804;(-)-1,5-dimethyl-6-(2-methyl-4-((3-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-2,4(1H,3H)-pyrimidinedione;2,4(1H,3H)-Pyrimidinedione, 1,5-dimethyl-6-(2-methyl-4-((3-(trifluoromethyl)-2-pyridinyl)oxy)phenyl)-, (-)-;SCHEMBL16334991;DTXSID301337071;tavapadonum;1,5-dimethyl-6-[2-methyl-4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-2,4(1H,3H)-pyrimidinedione;1,5-dimethyl-6-(2-methyl-4-((3-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione;1,5-Dimethyl-6-(2-methyl-4-((3-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)pyrimidine-2,4(1H,3H)-dione;1,5-dimethyl-6-(2-methyl-4-{[3-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione;Tavapadon?;DB-186035;Tavapadon [USAN];DB14899;1643489-24-0;G17190;6-(4-(3-(Trifluoromethyl)pyridin-2-yloxy)-2-methylphenyl)-1,5-dimethylpyrimidine-2,4(1h,3h)-dione;Tavapadon (USAN/INN);PF-06649751;PF 06649751;PF-6649751;PF-06649751;PF06649751;PF 06649751;HY-119486A;86W;TAVAPADON [INN];(-)-1,5-DIMETHYL-6-(2-METHYL-4-((3-(TRIFLUOROMETHYL)-2-PYRIDINYL)OXY)PHENYL)-2,4(1H,3H)-PYRIMIDINEDIONE;CHEMBL3697617;(-)-1,5-Dimethyl-6-(2-methyl-4-((3-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)pyrimidine-2,4(1H,3H)-dione;PT4P8MJP8L;EX-A3416;Tavapadon (USAN);MS-26523;

标识符

InChIKey:
AKQXQLUNFKDZBN-UHFFFAOYSA-N
Inchi:
1S/C19H16F3N3O3/c1-10-9-12(28-17-14(19(20,21)22)5-4-8-23-17)6-7-13(10)15-11(2)16(26)24-18(27)25(15)3/h4-9H,1-3H3,(H,24,26,27)
SMILES:
C1(=O)N(C)C(C2=CC=C(OC3=NC=CC=C3C(F)(F)F)C=C2C)=C(C)C(=O)N1

6-[4-(3-Trifluoromethylpyridin-2-yloxy)-2-methylphenyl]-1,5-dimethyl-2,4(1H,3H)-pyrimidinedione(1643462-64-9)物化性质

计算特性

  • 精确分子量 : 391.11437587g/mol
  • 氢键供体数量 : 1
  • 氢键受体数量 : 7
  • 可旋转化学键数量 : 3
  • 同位素质量 : 391.11437587g/mol
  • 重原子数量 : 28
  • 复杂度 : 665
  • 同位素原子数量 : 0
  • 确定原子立构中心数量 : 0
  • 不确定原子立构中心数量 : 0
  • 确定化学键立构中心数量 : 0
  • 不确定化学键立构中心数量 : 0
  • 共价键单元数量 : 1
  • 疏水参数计算参考值(XlogP) : 3.3
  • 拓扑分子极性表面积 : 71.5Ų

6-[4-(3-Trifluoromethylpyridin-2-yloxy)-2-methylphenyl]-1,5-dimethyl-2,4(1H,3H)-pyrimidinedione(1643462-64-9)推荐厂家 更多厂家(2)

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15026964105
汤思磊 2881489226
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MedChemExpress(MCE 中国) 13611715263
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