40216-83-9 (反式-4-羟基-L-脯氨酸甲酯盐酸盐,H-Hyp-OMe hydrochloride)

CAS号:
40216-83-9
中文名称:
反式-4-羟基-L-脯氨酸甲酯盐酸盐
英文名称:
H-Hyp-OMe hydrochloride
分子式:
C6H12ClNO3
分子量:
181.617381095886
简介:
H-Hyp-OMe (hydrochloride) 是不可降解 (non-cleavable) 的 ADC linker,用于合成抗体偶联活性分子 (ADCs)。H-Hyp-OMe (hydrochloride) 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker,可用于合成 PROTAC。

反式-4-羟基-L-脯氨酸甲酯盐酸盐(40216-83-9)名称与标识符

名称

中文别名:
反式-4-羟基-L-脯氨酸甲酯盐酸盐;L-羟脯氨酸甲酯盐酸盐;(2S,4R)-4-羟基-L-脯氨酸甲酯;羟脯氨酸甲酯盐酸盐;(1-壬基)三苯基溴化磷;5-溴-2-甲氧基苯甲醇;L-4-羟脯氨酸甲酯盐酸盐;L-4-羟脯氨酸甲酯盐酸盐,L-4-Hydroxyproline methyl ester;trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride 反式-4-羟基-L-脯氨酸甲酯盐酸盐;反式-4-羟基-L-脯氨酸甲酯盐酸盐及合成技术;L-4-羟基脯氨酸甲酯盐酸盐;L-羟脯氨酸甲酯盐酸;反-4-羟基-L-脯氨酸甲酯盐酸盐;(2S,4R)-4-羟基吡咯烷-2-甲酸甲酯盐酸盐;
英文别名:
(2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride;trans-4-Hydroxy-L-proline methyl ester;4-HYDROXY-L-PROLINE METHYL ESTER HCl;H-HYP-OME HCL;H-L-HYP-OME HCL;HYDROXYPROLINE-OME HCL;L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE;L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT;L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE;L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT;L-TRANS-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT;Methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride;trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride;H-Hyp-OMe·HCl;Hydroxyproline methyl ester hydrochloride;(2S,4R)-2-CARBOMETHOXY-4-HYDROXYPYRROLIDINE HYDROCHLORIDE;H-Hyp-Ome.HCL;H-O-Hyp-OMe·HCl;L-4-Hydroxyproline methyl ester;Trans-4-Hydroxy-L-Proline Methyl Ester, Hydrochloride Salt;(2S,4R)-2-methoxycarbonyl-4-hydroxypyrrolidine hydrochloride;(2S,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride;(2S,4R)-4-hydroxy-L-proline methyl ester;(2S,4R)-4-Hydroxy-pyrrolidine-2-car;Hyp-Ome HCL;L-HYDROXYPROLINE METHYL ESTER HCL;methyl (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylate hydrochloride;Methyl L-Hydroxyprolinate Hydrochloride;(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid Methyl Ester Hydrochloride;L-Proline,4-hydroxy-, methyl ester, hydrochloride, (4R)- (9CI);L-Proline, 4-hydroxy-, methylester, hydrochloride, trans-;Proline, 4-hydroxy-, methyl ester, hydrochloride(7CI);(2S,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl esterhydrochloride;(4R)-4-Hydroxy-L-proline methyl ester hydrochloride;4-Hydroxy-L-proline methylester hydrochloride;4-Hydroxyproline methyl ester hydrochloride;4-trans-Hydroxy-L-proline methyl ester hydrochloride;L-Hydroxyproline methyl ester hydrochloride;Methyl trans-4-hydroxy-L-prolinatehydrochloride;Hydroxyproline methylester hydrochloride;Methyl(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylate hydrochloride;MethylL-hydroxyprolinate hydrochloride;H-Hyp-OMe hydrochloride;1001333-91-0;H-Hyp-OMe-HCl;A7333;336192-08-6;J-300156;4(R)-hydroxypyrrolidine-2(S)-carboxylic acid methyl ester hydrochloride;AKOS015924093;(4R)-4-Hydroxy-L-proline methyl ester HCl;L-hydroxyproline methylester-hydrochloride;methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate;hydrochloride;EN300-72831;L-hydroxyproline rnethylester hydrochloride;DTXSID50932327;methyl (4R)-4-hydroxy-L-prolinate hydrochloride;trans-4-hydroxy-l-proline methylester hydrochloride salt;PS-8529;Hyp-OMe. HCl;L-Proline, 4-hydroxy-, methyl ester, hydrochloride, (4R)-;AM20100071;(2S,4R)-methyl4-hydroxypyrrolidine-2-carboxylatehydrochloride;L-4-Hydroxyproline methyl ester hydrochloride, >=98.0% (TLC);40216-83-9;(2S,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester HCl;(2S, 4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride;Methyl 4-hydroxyprolinatato--hydrogen chlorido (1/1);L-hydroxyproline methylester hydrochloride;H-Hyp-OMe (hydrochloride);KLGSHNXEUZOKHH-JBUOLDKXSA-N;CS-M0623;trans-4-Hydroxy-L-proline, methyl ester, hydrochloride;(2S,4R)-4-hydroxyproline methyl ester hydrochloride;HY-76043;Methyl trans-4-Hydroxypyrrolidine-2-carboxylate Hydrochloride;(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate HCl salt;Q-101694;methyl (2s,4r)-4-hydroxypyrrolidine-2-carboxylate hydrochloride salt;trans-4-hydroxyproline methyl ester hydrochloride;trans-L-Hydroxyproline methyl ester hydrochloride;MFCD00080855;(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate-HCl salt;SCHEMBL133898;L-hydroxyproline methylester.hydrochloride;(2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate HCl;CHEMBL552640;(2S,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride;(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate, hydrochloride;AC-4514;AKOS000278437;Rel-methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride;

标识符

MDL:
MFCD00080855
InChIKey:
KLGSHNXEUZOKHH-JBUOLDKXSA-N
Inchi:
1S/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5+;/m1./s1
SMILES:
Cl.O[C@H]1CN[C@H](C(=O)OC)C1
BRN:
4716932

反式-4-羟基-L-脯氨酸甲酯盐酸盐(40216-83-9)物化性质

实验特性

  • LogP : -0.78900
  • PSA : 58.56000
  • 沸点 : No data available
  • 熔点 : 152-164°C
  • 蒸气压 : No data available
  • 闪点 : 103.3℃
  • 颜色与性状 : White to Yellow Solid
  • 溶解性 : 未确定
  • 比旋光度 : -24° to -31° (c=2, H2O)

计算特性

  • 精确分子量 : 145.07400
  • 氢键供体数量 : 2
  • 氢键受体数量 : 4
  • 可旋转化学键数量 : 2
  • 同位素质量 : 181.051
  • 重原子数量 : 11
  • 复杂度 : 137
  • 同位素原子数量 : 0
  • 确定原子立构中心数量 : 2
  • 不确定原子立构中心数量 : 0
  • 确定化学键立构中心数量 : 0
  • 不确定化学键立构中心数量 : 0
  • 共价键单元数量 : 2
  • 疏水参数计算参考值(XlogP) : 未确定
  • 表面电荷 : 0
  • 拓扑分子极性表面积 : 58.6

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反式-4-羟基-L-脯氨酸甲酯盐酸盐(40216-83-9)相关文献

  • 1. Diastereoselective synthesis of 2-alkylated 4-silyloxyproline esters
    Tatsunori Sato,Satomi Kawasaki,Nobuo Oda,Sh?ko Yagi,Serry A. A. El Bialy,Jun'ichi Uenishi,Masashige Yamauchi,Masazumi Ikeda J. Chem. Soc. Perkin Trans. 1 2001 2623
  • 2. Synthesis of bridged azabicyclic compounds using radical translocation reactions of 1-(o-bromobenzoyl)-2-(prop-2-enyl)pyrrolidines
    Tatsunori Sato,Yasuhiro Kugo,Erina Nakaumi,Hiroyuki Ishibashi,Masazumi Ikeda J. Chem. Soc. Perkin Trans. 1 1995 1801

反式-4-羟基-L-脯氨酸甲酯盐酸盐(40216-83-9)参考资料

Reaxys RN:
3566975
Beilstein:
4716932
PubChem CID: