4282-78-4 (孟鲁司特钠顺式异构体,N-Propargyl Phenothiazine)

_35%

反应条件：

1.1 Reagents: Sodium carbonate Solvents: Toluene ; 30 min, rt
1.2 Solvents: Toluene ; 24 h, reflux

参考文献：

Accessing Heteroannular Benzoxazole and Benzimidazole Scaffolds via Carbodiimides Using Azide-Isocyanide Cross Coupling as Catalyzed by Mesoionic Singlet Palladium Carbene Complexes Derived from Phenothiazine Moiety

Dey, Shreyata ; Ghosh, Prasenjit, ACS Omega, 2023, 8(12), 11039-11064

合成路线：1 步

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Dimethylformamide ; 15 h, rt
1.2 Solvents: Dimethylformamide ; 20 min, rt; 6 h, rt

参考文献：

Renewable SiO2 as support for NiO catalyst for regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles from azide-alkyne cycloaddition in aqueous media

Boggala, Sasikumar; Perupogu, Vijayanand; Varimalla, Shirisha; Manda, Kalpana; Akula, Venugopal, Molecular Catalysis, 2022, 521,

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Ammonium chloride Solvents: Glucose , Urea ; rt; 75 - 90 min, 78 - 80 °C

参考文献：

Sugar-urea-salt eutectic mixture as an efficient green solvent for N-alkylation of heterocyclic secondary amines

Kumar, Koravangala S. Vinay; Swaroop, Toreshettahally R.; Ravi Singh, Krishna; Rangappa, Kanchugarakoppal S.; Sadashiva, Maralinganadoddi P., Chemical Data Collections, 2020, 29,

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Dimethylformamide ; 4 h, rt

参考文献：

One-Pot Regioselective Synthesis of Some Novel Isoxazole-Phenothiazine Hybrids and Their Antibacterial Activity

Guguloth, V.; Paidakula, S.; Vadde, R., Russian Journal of General Chemistry, 2020, 90(3), 470-475

合成路线：1 步

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Acetonitrile ; 15 min
1.2 Solvents: Dimethylformamide ; 20 min; 6 h, rt

参考文献：

Unravel the surface active sites on Cu/MgLaO solid base catalyst by DRIFT spectroscopy and adsorption techniques for the synthesis of triazoles by click reaction

Bilakanti, Vishali; Boosa, Venu; Gutta, Naresh ; Velisoju, Vijay Kumar ; Inkollu, Sreedhar; et al, Molecular Catalysis, 2019, 476,

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; 0 °C; 30 min, rt
1.2 8 h, rt
1.3 Reagents: Water ; cooled

参考文献：

Molecular hybridization approach for phenothiazine incorporated 1,2,3-triazole hybrids as promising antimicrobial agents: Design, synthesis, molecular docking and in silico ADME studies

Reddyrajula, Rajkumar; Dalimba, Udayakumar; Madan Kumar, S., European Journal of Medicinal Chemistry, 2019, 168, 263-282

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Acetone ; 6 h, reflux

参考文献：

Molecular diversity of trimethoxyphenyl-1,2,3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors

Fu, Dong-Jun; Li, Ping; Wu, Bo-Wen; Cui, Xin-Xin; Zhao, Cheng-Bin; et al, European Journal of Medicinal Chemistry, 2019, 165, 309-322

合成路线：1 步

_64%