50629-82-8 (卤甲松,Halometasone)

卤甲松;4H-1-苯并吡喃-4-酮, 2,3-二氢-5,7-二羟基-3-(4-羟基苯基)-;卤米松;(6Α,11Β,16Α)-2-氯-6,9-二氟-11,17,21-三羟基-16-甲基孕甾-1,4-二烯-3,20-二酮;

Halometasone;2-Chloroflumethasone;2-Chlor-6a,9-difluor-11b,17,21-trihydroxy-16a-methyl-1,4-pregnadien-3,20-dion;(6S,8S,9R,10S,11S,13S,14S,16R,17R)-2-chloro-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;CHEMBL1587228;AB00639905-06;Halometasona;Halometasonum;50629-82-8;CCG-100880;D07202;2-Chlor-6alpha,9-difluor-11beta,17,21-trihydroxy-16alpha-methyl-1,4-pregnadien-3,20-dion;CS-0453061;DTXSID1048382;(6S,8S,9R,10S,11S,13S,14S,16R,17R)-2-chloro-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;Halometasone [INN];EINECS 256-664-9;MLS000759439;2-Chloro-6alpha,9-difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione;HALOMETASONE [WHO-DD];SCHEMBL4872;HALOMETASONE [MI];Q10910139;AS-78199;HMS2232N17;DB13728;HMS2051C16;SMR000466330;CHEBI:135724;MLS001424089;Halometasona [INN-Spanish];2-CHLORO-6.ALPHA.,9-DIFLUORO-11.BETA.,17,21-TRIHYDROXY-16.ALPHA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE;UNII-J69Z9UU41Z;Pregna-1,4-diene-3,20-dione, 2-chloro-6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6alpha,11beta,16alpha)-;AC-3528;Halometasone (INN);Q-101370;AKOS025402048;HALOMETASONE [MART.];NC00130;J69Z9UU41Z;Halometasonum [INN-Latin];HALOMETASONE (MART.);Halometasonum (INN-Latin);DTXCID7028356;GGXMRPUKBWXVHE-MIHLVHIWSA-N;(1R,2S,8S,10S,11S,13R,14R,15S,17S)-4-chloro-1,8-difluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadeca-3,6-dien-5-one;D07AC12;Halometasona (INN-Spanish);2-chloro-6alpha, 9-difluoro-11beta, 17,21-trihydroxy-16alpha-methylpregna-1,4-dien-3,20-dione;(1R,2S,8S,10S,11S,13R,14R,15S,17S)-4-chloro-1,8-difluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one;

MFCD00866091

GGXMRPUKBWXVHE-MIHLVHIWSA-N

1S/C22H27ClF2O5/c1-10-4-11-12-5-15(24)13-6-16(27)14(23)7-19(13,2)21(12,25)17(28)8-20(11,3)22(10,30)18(29)9-26/h6-7,10-12,15,17,26,28,30H,4-5,8-9H2,1-3H3/t10-,11+,12+,15+,17+,19+,20+,21+,22+/m1/s1

ClC1C(C=C2[C@H](C[C@@H]3[C@@]([C@]2(C=1)C)([C@H](C[C@]1(C)[C@@](C(CO)=O)([C@H](C)C[C@H]13)O)O)F)F)=O

256-664-9

化合物(Ⅰ)先和氯气反应，对1、2位双键进行加成，再在吡啶作用下，脱去氯化氢，在1、2位重新形成双键；然后水解，得到卤米松。