6211-15-0 (硫酸**,Morphine Sulfate)

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Section 1. Chemical Product and Company Identification
    Morphine sulfate
    Common Name/
    Trade Name
    Morphine sulfate

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Section 4. First Aid Measures
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at    
    least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.
    Skin Contact        Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.    
    Cold water may be used.
    Serious Skin Contact        Not available.    
    Inhalation        If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get    
    medical attention.
    Serious Inhalation        Not available.    
    Ingestion        Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an    
    unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
    clothing such as a collar, tie, belt or waistband.
    Serious Ingestion        Not available.    

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Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Flash Points        Not available.    
    Flammable Limits        Not available.    
    These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...).
    Products of Combustion
    Fire Hazards in Presence of Slightly flammable to flammable in presence of open flames and sparks, of heat.
    Various Substances        Non-flammable in presence of shocks.    
    Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
    of Various Substances        Slightly explosive in presence of open flames and sparks.    
    Fire Fighting Media        SMALL FIRE: Use DRY chemical powder.    
    and Instructions        LARGE FIRE: Use water spray, fog or foam. Do not use water jet.    
    Special Remarks on        As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.    
    Fire Hazards
    Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust
    Hazards        explosion hazard.    

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Section 6. Accidental Release Measures
    Small Spill        Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by    
    spreading water on the contaminated surface and dispose of according to local and regional authority
    requirements.
    Large Spill
    Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
    on the contaminated surface and allow to evacuate through the sanitary system.
    Morphine sulfate

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Section 7. Handling and Storage
    Precautions        Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the    
    residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust.
    Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If
    ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles
    such as oxidizing agents, alkalis.
    Storage        Keep container tightly closed. Keep container in a cool, well-ventilated area.    

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Section 8. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below    
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.    
    Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
    a Large Spill        to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist    
    BEFORE handling this product.
    Exposure Limits        Not available.    

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Section 9. Physical and Chemical Properties
    Physical state and appearance Solid. (Powdered solid.)        Odor        Odorless.    
    Not available.
    Taste
    Molecular Weight        758.85 g/mole    
    White.
    Color
    Not available.
    pH (1% soln/water)
    Boiling Point        Not available.    
    250°C (482°F)
    Melting Point
    Critical Temperature        Not available.    
    Specific Gravity        Not available.    
    Vapor Pressure        Not applicable.    
    Vapor Density        Not available.    
    Not available.
    Volatility
    Odor Threshold        Not available.    
    Water/Oil Dist. Coeff.        Not available.    
    Ionicity (in Water)        Not available.    
    Dispersion Properties        See solubility in water.    
    Solubility        Soluble in cold water.    

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Section 10. Stability and Reactivity Data
    Stability        The product is stable.    
    Instability Temperature        Not available.    
    Conditions of Instability        Excessive heat, incompatible materials    
    Incompatibility with various Reactive with oxidizing agents, alkalis.
    substances
    Morphine sulfate
    Corrosivity        Non-corrosive in presence of glass.    
    Special Remarks on        Incompatible with alkalies, tannic acid, iodic acid, potassium permanganate, borax, chlorates, ferric chloride,    
    Reactivity        iodides, lead acetate, magnesia, spirit nitrous ether, mercury bichloride, and gold salts. Sensitive to light.    
    Special Remarks on        Not available.    
    Corrosivity
    Polymerization        Will not occur.    

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Section 11. Toxicological Information
    Routes of Entry        Inhalation. Ingestion.    
    Toxicity to Animals        Acute oral toxicity (LD50): 973 mg/kg [Rat].    
    Chronic Effects on Humans May cause damage to the following organs: central nervous system (CNS).
    Other Toxic Effects on        Hazardous in case of ingestion, of inhalation.    
    Humans        Slightly hazardous in case of skin contact (irritant, permeator).    
    Special Remarks on        Not available.    
    Toxicity to Animals
    Special Remarks on        May cause adverse reproductive effects and birth defects (teratogenic). May affect genetic material (mutagenic)    
    Chronic Effects on Humans        Human: passes through the placenta, excreted in maternal milk.    
    Special Remarks on other        Acute Potential Health Effects:    
    Toxic Effects on Humans        Skin: May cause slight irritation. May be absorbed through broken or inflammed skin.    
    Eyes: May cause slight eye irritation.
    Inhalation: May cause respiratory tract and mucous membrane irritaiton with sneezing and/or coughing. Inhalation
    of large quantities may cause lung edema, respiratory difficulties, dizziness, and have an anesthetic effect
    (symptoms similar to ingestion).
    Ingestion: Narcotic! May Be Habit Forming! It may cause gastrointestinal tract irritaiton (disturbances) with
    nausea, vomiting, constipation. Ingestion of large amounts may affect behavior/central nervous system
    (drowsiness, dizziness, slurred speech, somnolence, mental exhilaration, confusion, mood changes,
    restlessness), metabolism (anorexia), cardiovascular system (heart palpitations, low blood pressure, hypertension,
    arrhythmias, acute ventricular failrue, bradycardia, cardia arrest). Other symptoms may include dry mouth,
    sweating, facila flushing, rash, non-responsive contracted pupils, and hypothermia, labored breathing causing
    cyanosis, flaccid skeletal muscles. Pneumonia, pulmonary edema, shock, coma, and even death may occur in
    severe cases.
    Chronic Potential Health Effects:
    Inhalation: Prolonged or repeated inhalation may cause respiratory irritation, tightness of the chest, asthma, and
    bronchitis.
    Ingestion: Prolonged or repeated ingestion may cause habituation or addiction. It may affect the blood, urinary
    system , and metabolism (anorexia).
    Skin: May cause contact dermatitis in sensitized indivduals
    Sensitive individuals may also develop anaphylatic (allergic) reactions upon re-exposure by inhalation or ingestion.

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Section 12. Ecological Information
    Not available.
    Ecotoxicity
    Not available.
    BOD5 and COD
    Products of Biodegradation        Possibly hazardous short term degradation products are not likely. However, long term degradation products may    
    arise.
    Toxicity of the Products        The products of degradation are less toxic than the product itself.    
    of Biodegradation
    Not available.
    Special Remarks on the
    Products of Biodegradation
    Morphine sulfate

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Section 13. Disposal Considerations
    Waste Disposal        Waste must be disposed of in accordance with federal, state and local environmental    
    control regulations.

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Section 14. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    Not applicable.
    Identification
    Not applicable.
    Special Provisions for
    Transport
    DOT (Pictograms)

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Section 15. Other Regulatory Information and Pictograms
    No products were found.
    Federal and State
    Regulations
    California
    Proposition 65
    Warnings
    Other Regulations        Morphine Sulfate (CAS no. 64-31-3) is on the Canadian Domestic Substances list.    
    Morphine Sulfate Pentahydrate (CAS no. 6211-15-0) is not in the Canadian Domestic Substances list.
    WHMIS (Canada) Not controlled under WHMIS (Canada).
    Other Classifications
    DSCL (EEC)        R22- Harmful if swallowed.        S2- Keep out of the reach of children.    
    S46- If swallowed, seek medical advice
    immediately and show this container or label.
    Health Hazard
    HMIS (U.S.A.)        1 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    1 0 Reactivity
    Health
    Reactivity
    0
    Specific hazard
    Personal Protection
    E
    WHMIS (Canada)
    (Pictograms)
    DSCL (Europe)
    (Pictograms)
    TDG (Canada)
    (Pictograms)
    Morphine sulfate
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or
    equivalent.

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SECTION 16 - ADDITIONAL INFORMATION
N/A