787-84-8 (二苯肼,N&#x27;-benzoylbenzohydrazide)

_98%

反应条件：

1.1 Reagents: Bromine , Hydrazine hydrate (1:1) ; 0 °C
1.2 0 - 10 °C; 5 s, 0 - 10 °C

参考文献：

Rapid generation of N,N'-diacylhydrazines by I2 or Br2/hydrazine hydrate: a facile route to 1,3,4-oxadiazoles

Pamar, Malavath Geeta; Gannimani, Ramesh; Govender, Patrick; Ramjugernath, Deresh; Nanjundaswamy, Hemmaragala Marishetty, Organic Chemistry: An Indian Journal, 2014, 10(1), 17-23

合成路线：1 步

_98%

参考文献：

Acetylenic ketones. Part VI. Reaction of aroylphenylacetylenes with hydrazine derivatives

Baddar, F. G.; Al-Hajjar, F. H.; El-Rayyes, N. R., Journal of Heterocyclic Chemistry, 1978, 15(3), 385-93

合成路线：1 步

15646-46-5

_97%

反应条件：

1.1 Solvents: 1,4-Dioxane
1.2 Reagents: Water

参考文献：

Migration of an acyl group in the pyrazole system: synthesis of 1-acyl-3-hydroxy-1H-pyrazoles and related derivatives. A new preparation of N,N '-diacylhydrazines

Kepe, Vladimir; Pozgan, Franc; Golobic, Amalija; Polanc, Slovenko; Kocevar, Marijan, Journal of the Chemical Society, 1998, (17), 2813-2816

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Methanaminium, N,N,N-trimethyl-, periodate (1:1) (polymer-supported)

参考文献：

Ammonium periodate, polymer-supported

Ley, Steven V.; Hazelwood, Andrew J., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2002, 1, 1-2

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Cesium carbonate Catalysts: Palladium (reaction product with tetraallylglycoluril-vinyl pyridine copolymer) , Imidazo[4,5-d]imidazole-2,5(1H,3H)-dione, tetrahydro-1,3,4,6-tetra-2-propen-1-yl… Solvents: Dimethyl sulfoxide ; 4 MPa, 120 °C

参考文献：

Stability or flexibility: Metal nanoparticles supported over cross-linked functional polymers as catalytic active sites for hydrogenation and carbonylation

Chen, Bingfeng; Li, Fengbo; Huang, Zhijun; Lu, Tao; Yuan, Guoqing, Applied Catalysis, 2014, 481, 54-63

合成路线：1 步

_95%

参考文献：

Polymer supported periodate: convenient method for oxidation of hydrazides

Salunkhe, D. G.; Jagdale, M. H.; Swami, S. S.; Salunkhe, M. M., Current Science, 1986, 55(18), 922-3

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Tetrahydrofuran ; 4 h, 0 °C

参考文献：

N-Amino-1,8-Naphthalimide is a Regenerated Protecting Group for Selective Synthesis of Mono-N-Substituted Hydrazines and Hydrazides

Manoj Kumar, Mesram; Venkataramana, Parikibanda; Yadagiri Swamy, Parikibanda; Chityala, Yadaiah, Chemistry - A European Journal, 2021, 27(70), 17713-17721

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium carbonate Solvents: Tetrahydrofuran , Water ; 0 °C; 1.5 h, rt

参考文献：

Copper-Catalyzed Cross-Coupling Between (E)-1,2-Diiodoethene and Carbazates: Entry to β-Functionalized N-Alkenylcarbazates

Casault, Pamela ; Ricard, Simon ; Daoust, Benoit, Letters in Organic Chemistry, 2022, 19(9), 803-810

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium peroxoborate Solvents: Acetic acid

参考文献：

Oxidation of hydrazides using sodium perborate: formation of N,N'-diacylhydrazines

Jadhav, Vidyadhar K.; Wadagaonkar, Prakash P.; Salunkhe, Manikrao M., Journal of the Chinese Chemical Society (Taipei), 1998, 45(6), 831-833

合成路线：1 步

55-21-0

_89%

反应条件：

1.1 Catalysts: Boric acid (H4B2O5) (sulfated) Solvents: Dimethyl sulfoxide ; 45 min, 70 °C; 70 °C → rt
1.2 Reagents: Water ; rt

参考文献：

Phthaloylation of amines, hydrazines, and hydrazides by N-substituted phthalimides using recyclable sulfated polyborate

Ganwir, Prerna; Jaydeokar, Swati; Chaturbhuj, Ganesh U., Results in Chemistry, 2022, 4,

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Pyridine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; rt; 6 h, rt

参考文献：

N-Methoxyamide: An Alternative Amidation Reagent in the Rhodium(III)-Catalyzed C-H Activation

Zhou, Chao; Zhao, Junqi; Guo, Weicong; Jiang, Jijun ; Wang, Jun, Organic Letters, 2019, 21(23), 9315-9319

合成路线：1 步

100-52-7

_89%

反应条件：

1.1 Reagents: tert-Butyl hydroperoxide , Hydrazine hydrate (1:1) Catalysts: Pyridinium, 1-(3-sulfopropyl)-, tetracosa-μ-oxododecaoxo[μ12-[phosphato(3-)-κO:κ… ; 8 h, 90 °C

参考文献：

Direct oxidative amidation of aldehydes with amines catalyzed by heteropolyanion-based ionic liquids under solvent-free conditions via a dual-catalysis process

Fu, Renzhong; Yang, Yang; Zhang, Jin; Shao, Jintao; Xia, Xuming; et al, Organic & Biomolecular Chemistry, 2016, 14(5), 1784-1793

合成路线：1 步

65-85-0

_88%

反应条件：

1.1 Reagents: Triethylamine , (Chloromethylene)dimethylammonium chloride , Hydrazine hydrate (1:1) Solvents: Acetonitrile ; 7 h, rt

参考文献：

Synthesis of acylhydrazines and, symmetrical and asymmetrical diacylhydrazines from carboxylic acid via the Vilsmeier reagent mediated process

Zarei, Maaroof; Nakhli, Maliheh Eslami, Research on Chemical Intermediates, 2017, 43(3), 1909-1918

合成路线：1 步

_87%

反应条件：

1.1 Solvents: Pyridine ; 36 h, reflux

参考文献：

Synthesis and in vitro urease inhibitory activity of benzohydrazide derivatives, in silico and kinetic studies

Abbas, Azhar; Ali, Basharat; Kanwal; Khan, Khalid Mohammed; Iqbal, Jamshed; et al, Bioorganic Chemistry, 2019, 82, 163-177

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Pyridine , 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 6 h, rt

参考文献：

Molecular Logic Gates and Switches Based on 1,3,4-Oxadiazoles Triggered by Metal Ions

Li, Ai-Fang; Ruan, Yi-Bin; Jiang, Qian-Qian; He, Wen-Bin; Jiang, Yun-Bao, Chemistry - A European Journal, 2010, 16(19), 5794-5802

合成路线：1 步

3426-89-9

65-85-0

_85%

反应条件：

1.1 Reagents: Hydrazine

参考文献：

A new synthesis of hydrazides by a direct condensation reaction

Chiriac, C. I., Revue Roumaine de Chimie, 1982, 27(3), 411-14

合成路线：1 步

825-56-9

618-32-6

_85%

反应条件：

1.1 Reagents: Water

参考文献：

Diazomethanes. V. The reactive behavior of diazomethyllithium

Muller, Eugen; Ludsteck, Dieter, Chemische Berichte, 1955, 88, 921-33

合成路线：1 步

_84%

反应条件：

1.1 Reagents: Benzoyl chloride Solvents: Toluene ; 2.5 h, reflux

参考文献：

A Ceric Ammonium Nitrate N-Dearylation of N-p-Anisylazoles Applied to Pyrazole, Triazole, Tetrazole, and Pentazole Rings: Release of Parent Azoles. Generation of Unstable Pentazole, HN5/N5-, in Solution

Butler, Richard N.; Hanniffy, John M.; Stephens, John C.; Burke, Luke A., Journal of Organic Chemistry, 2008, 73(4), 1354-1364

合成路线：1 步

_84%