79418-41-0 (3-氨基-7-羟基香豆素,3-Amino-7-hydroxy-2H-chromen-2-one)

反应条件：

1.1 Reagents: 1-Methylpiperazine , Ammonium chloride Solvents: Acetone , Water ; 9 h, reflux

参考文献：

Synthesis of 3-aminochromenes: the Zincke reaction revisited

Costa, Marta ; Rodrigues, Ana I.; Proenca, Fernanda, Tetrahedron, 2014, 70(33), 4869-4875

合成路线：1 步

946833-00-7

_96%

反应条件：

1.1 Catalysts: Trifluoroacetic acid Solvents: Chloroform ; 3 h, rt

参考文献：

Hydrolysis-free synthesis of 3-aminocoumarins

Kudale, Amit A.; Kendall, Jamie; Warford, C. Chad; Wilkins, Natasha D.; Bodwell, Graham J., Tetrahedron Letters, 2007, 48(29), 5077-5080

合成路线：1 步

1573010-11-3

_92%

反应条件：

1.1 Reagents: Hydrogen , Hydrochloric acid Catalysts: Palladium Solvents: Methanol ; 1 atm, cooled

参考文献：

Defining a minimum pharmacophore for simocyclinone D8 disruption of DNA gyrase binding to DNA

Gaskell, Lauren M.; Nguyen, Thuy; Ellis, Keith C., Medicinal Chemistry Research, 2014, 23(8), 3632-3643

合成路线：1 步

_74%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Ethanol , Water ; 1 h, 110 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ; pH 5 - 6

参考文献：

Highly efficient catalytic performance on CuAAC reaction by polymer-like supramolecular self-assemblies-Cu(I) in aqueous solution

Deng, Bin ; Yang, Jing ; Guo, Mengbi ; Yang, Rui, Applied Organometallic Chemistry, 2022, 36(6),

合成路线：1 步

_74%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Ethanol ; 150 min, reflux
1.2 Reagents: Water ; pH 4.5, 0 °C

参考文献：

Mild and highly efficient deacetylation of acetamido and acetoxy coumarins: A convenient and expeditious synthesis of substituted 3-aminocoumarins

Krajnakova, Jana; Joniak, Jakub; Putala, Martin ; Gorova, Renata; Jurdakova, Helena; et al, Synthetic Communications, 2021, 51(21), 3277-3291

合成路线：1 步

_74%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Ethanol , Water ; 2 h, reflux
1.2 Reagents: Sodium hydroxide Solvents: Water ; pH 5 - 6

参考文献：

A novel highly selective colorimetric sensor for Ni(II) ion using coumarin derivatives

Jiang, Jinqiang; Gou, Chao; Luo, Jing; Yi, Chenglin; Liu, Xiaoya, Inorganic Chemistry Communications, 2012, 15, 12-15

合成路线：1 步

_66%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Ethanol , Water ; 1 h, reflux; reflux → rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ; neutralized, rt

参考文献：

Synthesis and mesomorphic properties of coumarin derivatives with chalcone and imine linkages

Durgapal, Sunil Dutt; Soni, Rina; Soman, Shubhangi S.; Prajapati, A. K., Journal of Molecular Liquids, 2020, 297,

合成路线：1 步

_65%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Ethanol , Water ; 1 h, reflux
1.2 Reagents: Sodium bicarbonate Solvents: Water ; neutralized

参考文献：

Coumarin derivatives containing Schiff base and ester mesogenic core: Synthesis, mesomorphic behaviour and DFT calculations

Katariya, Kanubhai D.; Soni, Rina ; Nakum, Kiran J.; Soman, Shubhangi S. ; Hagaar, Mohamed, Journal of Molecular Structure, 2022, 1262,

合成路线：1 步

_61%

反应条件：

1.1 Reagents: Sodium acetate Solvents: Acetic anhydride ; 6 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Ethanol ; 1 h, reflux

参考文献：

Synthesis and properties of Cu2+ fluorescence probe based on coumarin-imine

Wang, Jianhong; Guo, Xinling; Zhao, Huijun; Luo, Zhaoyang; Hou, Xufeng; et al, Huaxue Yanjiu, 2014, 25(4), 345-348

合成路线：1 步

_61%

反应条件：

1.1 Reagents: Sodium acetate Solvents: Acetic anhydride ; 8 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Ethanol , Water ; 2 h, reflux
1.3 Reagents: Sodium hydroxide Solvents: Water ; pH 5 - 6

参考文献：

A Highly Sensitive Fluorescence Probe for Fast Thiol-Quantification Assay of Glutathione Reductase

Yi, Long; Li, Heyang; Sun, Lu; Liu, Liangliang; Zhang, Caihong; et al, Angewandte Chemie, 2009, 48(22), 4034-4037

合成路线：1 步

_61%

反应条件：

1.1 Reagents: Sodium acetate Solvents: Acetic anhydride ; 8 h, reflux
1.2 Solvents: Water ; 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Ethanol , Water ; 2 h, reflux
1.4 Reagents: Sodium hydroxide Solvents: Water ; pH 5 - 6, 0 °C

参考文献：

A colorimetric and "turn-on" fluorescent chemosensor for Zn(II) based on coumarin Shiff-base derivative

Li, He-yang; Gao, Shuang; Xi, Zhen, Inorganic Chemistry Communications, 2009, 12(4), 300-303

合成路线：1 步

33259-31-3

_60%

反应条件：

1.1 Reagents: Acetic acid , Acetic anhydride , Hydrogen iodide Solvents: Water ; 5 h, 110 °C

参考文献：

Tyrosine-like condensed derivatives as tyrosinase inhibitors

Matos, Maria Joao; Santana, Lourdes; Uriarte, Eugenio; Serra, Silvia; Corda, Marcella; et al, Journal of Pharmacy and Pharmacology, 2012, 64(5), 742-746

合成路线：1 步

_52%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Methanol ; reflux

参考文献：

Novel synthesis and cytotoxic activity of some chromeno[3,4-b]pyrrol-4(3H)-ones

Soman, S. S.; Thaker, T. H.; Rajput, R. A., Chemistry of Heterocyclic Compounds (New York, 2011, 46(12), 1514-1519

合成路线：1 步

_51%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Ethanol ; 2 h, rt → reflux
1.2 Reagents: Sodium hydroxide Solvents: Water ; pH 6, cooled

参考文献：

Synthesis of coumarin-Schiff base compounds and metal ion recognition performances of the products

Wang, Ling-yun; Ye, De-cheng; Cao, De-rong, Huanan Ligong Daxue Xuebao, 2012, 40(5), 46-51

合成路线：1 步

_18%

反应条件：

1.1 Reagents: Acetic anhydride , Sodium acetate ; 4 h, rt → reflux; reflux → rt
1.2 Solvents: Water ; 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Ethanol ; 1 h, 0 °C → reflux; cooled
1.4 Reagents: Sodium hydroxide Solvents: Water ; pH 5, 0 °C

参考文献：

"Turn-on" fluorescence probe integrated polymer nanoparticles for sensing biological thiol molecules

Ang, Chung Yen; Tan, Si Yu; Lu, Yunpeng; Bai, Linyi; Li, Menghuan; et al, Scientific Reports, 2014, 4,

合成路线：1 步

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Ethanol ; reflux

参考文献：

Coumarin-based fluorescent probe for the detection of glutathione and nitroreductase

Tian, Xue ; Kumawat, Lokesh K.; Bull, Steven D. ; Elmes, Robert B. P. ; Wu, Luling; et al, Tetrahedron, 2021, 82,

合成路线：1 步

反应条件：

1.1 Reagents: Sodium acetate Solvents: Acetic anhydride ; reflux
1.2 Reagents: Hydrochloric acid Solvents: Ethanol ; reflux

参考文献：

Design and synthesis of 3-benzylaminocoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors

Hng, Yue; Lin, Mei-Hsiang; Lin, Tzung-Sheng; Liu, I-Chen; Lin, I-Chun; et al, Bioorganic Chemistry, 2020, 96,

合成路线：1 步

参考文献：

Discovery two potent and new inhibitors of 15-lipoxygenase: (E)-3-((3,4-dihydroxybenzylidene) amino)-7-hydroxy-2H-chromen-2-one and (E)-O-(4-(((7-hydroxy-2-oxo-2H-chromen-3-yl) imino)methine) phenyl)dimethylcarbamothioate

Nunez, Carolina; Morales, Nicole; Garcia-Beltran, Olimpo; Mascayano, Carolina; Fierro, Angelica, Medicinal Chemistry Research, 2017, 26(11), 2707-2717

合成路线：1 步