95-01-2 (2,4-二羟基苯甲醛,2,4-Dihydroxybenzaldehyde)

67-66-3

_98%

反应条件：

1.1 Catalysts: 6A,6B,6C,6D,6E,6F,6G-Heptakis-O-(2-hydroxypropyl)-β-cyclodextrin Solvents: Methanol , Water

参考文献：

β-Cyclodextrin mediated regioselective photo-Reimer-Tiemann reaction of phenols

Ravichandran, Ramaswamy, Journal of Molecular Catalysis A: Chemical, 1998, 130(3),

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Dimethylformamide ; rt; 1 h, rt
1.2 30 min, rt; 1 h

参考文献：

Fast preparation method of aromatic aldehydes from carbazole and hydroxyaromatic derivatives under microwave irradiation

Pajda, Michal; Bogdal, Dariusz, Modern Polymeric Materials for Environmental Applications, 2006, 129, 129-132

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Phosphorus oxychloride ; 1 h, 65 °C

参考文献：

A new method for the fast preparation of aromatic aldehydes from carbazole and hydroxyaromatic derivatives

Pajda, Micha; Bogdal, Dariusz, International Electronic Conferences on Synthetic Organic Chemistry, 2004, 1105, 1105-1108

合成路线：1 步

175290-02-5

_97%

反应条件：

1.1 Solvents: Water

参考文献：

Preparation of 2,4-dihydroxybenzaldehyde by the Vilsmeier-Haack reaction

Mendelson, Wilford L.; Hayden, Stuart, Synthetic Communications, 1996, 26(3), 603-10

合成路线：1 步

148741-41-7

_97%

反应条件：

1.1 Reagents: Hydrochloric acid , Water Solvents: Diethyl ether

参考文献：

Hydrogen cyanide. VI. Mechanism of Gattermann's hydrogen cyanide aldehyde synthesis

Hinkel, L. E.; Ayling, E. E.; Beynon, J. H., Journal of the Chemical Society, 1936, 184, 184-5

合成路线：1 步

557-21-1

_95%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Diethyl ether

参考文献：

Simplification of the Gattermann synthesis of hydroxy aldehydes

Adams, Roger; Levine, I., Journal of the American Chemical Society, 1923, 45, 2373-7

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Dimethylformamide ; 0 - 5 °C; 5 °C → 60 °C; 8 h, 60 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ; 30 min, pH 7, cooled

参考文献：

Method for preparing 4-butyl-resorcinol

, China, , ,

合成路线：1 步

676227-04-6

_93%

反应条件：

1.1 Solvents: Chloroform ; 1 h, rt; 1 h, reflux
1.2 Reagents: Sodium acetate Solvents: 1,4-Dioxane ; 1 h, reflux

参考文献：

The Use of Solid-Phase Supported 1-N-Piperazine-4-N-carboxaldehyde in Vilsmeier Reactions

Rivero, I. A.; Espinoza, K. A.; Ochoa, A., Journal of Combinatorial Chemistry, 2004, 6(2), 270-274

合成路线：1 步

62417-02-1

_92%

反应条件：

1.1 Reagents: Boron trifluoride etherate Solvents: 1,4-Dioxane ; 3 - 6 h, rt

参考文献：

Highly efficient and selective deprotection method for prenyl, geranyl, and phytyl ethers and esters using boron trifluoride-etherate

Narender, T.; Venkateswarlu, K.; Madhur, G.; Reddy, K. Papi, Synthetic Communications, 2013, 43(1), 26-33

合成路线：1 步

41777-08-6

_92%

反应条件：

1.1 Reagents: Sodium acetate Solvents: Ethanol , Water ; 5 h, reflux

参考文献：

NaOAc-mediated selective deprotection of aromatic acetates and its application in the synthesis of natural products

Narender, T.; Reddy, K. Papi; Madhur, G., Synthetic Communications, 2009, 39(11), 1949-1956

合成路线：1 步

100-97-0

_91%

反应条件：

1.1 Reagents: Sulfuric acid ; 0.5 h, rt

参考文献：

Mechanochemical Duff Reaction in Solid Phase for Easy Access to Mono- and Di-formyl Electron-Rich Arenes

Saha, Soumik; Bhosle, Akhil A.; Chatterjee, Amrita ; Banerjee, Mainak, Journal of Organic Chemistry, 2023, 88(14), 10002-10013

合成路线：1 步

50-00-0

_90%

反应条件：

1.1 Catalysts: Magnesium oxide ; 15 min

参考文献：

Efficient microwave-assisted regioselective one pot direct ortho-formylation of phenol derivatives in the presence of nanocrystalline MgO as a solid base catalyst under solvent-free conditions

Naeimi, Hossein; Zakerzadeh, Elham, New Journal of Chemistry, 2018, 42(6), 4590-4595

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Diphosphoryl chloride

参考文献：

The Vilsmeier reaction of fully conjugated carbocycles and heterocycles

Jones, Gurnos; Stanforth, Stephen P., Organic Reactions (Hoboken, 1997, 49,

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Diphosphoryl chloride

参考文献：

Vilsmeier formylation and glyoxylation reactions of nucleophilic aromatic compounds using pyrophosphoryl chloride

Downie, Ian M.; Earle, Martyn J.; Heaney, Harry; Shuhaibar, Khamis F., Tetrahedron, 1993, 49(19), 4015-34

合成路线：1 步

613-45-6

_84%

反应条件：

1.1 Reagents: Trimethylsilyl iodide Solvents: Chloroform

参考文献：

Demethylation of some aryl methyl ethers and selective demethylation of some pyrones by the use of iodotrimethylsilane

Younis, Y. M. H., International Journal of Chemistry (Calcutta, 2001, 11(2), 75-85

合成路线：1 步

30030-25-2

_82%

反应条件：

1.1 Reagents: Potassium carbonate , Potassium iodide Solvents: Acetone ; 240 h, reflux; reflux → rt

参考文献：

Polymer bound transition metal complexes for catalytic oxidation of cyclohexene with molecular oxygen

Hao, Chengjun; Zhao, Ganqing, Chinese Journal of Reactive Polymers, 2007, 16(1-2), 66-71

合成路线：1 步

_80%

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Acetonitrile ; 1 h, < 30 °C; 30 °C → -7 °C
1.2 Solvents: Acetonitrile ; -7 °C; < -3 °C; 3 h, -3 °C; 1 h, rt; rt → 0 °C; 1 h, 0 °C
1.3 Reagents: Sodium thiosulfate ; 30 min, 35 °C; 35 °C → 0 °C; 2 h, 0 °C

参考文献：

Synthesis of 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid methyl ester

Ling, Xinlong; Tang, Zhongfeng; Guo, Weimin; Yue, Zhiwen, Huagong Jishu Yu Kaifa, 2010, 39(4), 10-11

合成路线：1 步

673-22-3

_80%

反应条件：

1.1 Reagents: Pyridinium p-toluenesulfonate ; 2 min, 100 °C; cooled

参考文献：

Demethylation of aryl methyl ethers using pyridinium p-toluenesulfonate under microwave irradiation

Lamba, Mandeep S.; Makrandi, Jagdish K., Journal of Chemical Research, 2007, (10), 585-586

合成路线：1 步

_80%

反应条件：

1.1 Solvents: Acetonitrile
1.2 Reagents: Phosphorus oxychloride
1.3 Solvents: Water

参考文献：

Enantioselective acylation of 2-hydroxymethyl-2,3-dihydrobenzofurans catalyzed by lipase from Pseudomonas cepacia (Amano PS) and total stereoselective synthesis of (-)-(R)-MEM-protected arthrographol

Ramadas, S.; Krupadanam, G. L. D., Tetrahedron: Asymmetry, 2000, 11(16), 3375-3393

合成路线：1 步

_77%