79-44-7 (二甲氨基甲酰氯,N,N-dimethylcarbamoyl chloride)

反应条件：

1.1 Reagents: Thionyl chloride ; 4 h, rt → reflux

参考文献：

Discovery and Optimization of N-Acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-Steroidal Selective Glucocorticoid Receptor Modulators

Li, Dan ; Bao, Xiaodong; Pang, Jinping; Hu, Xueping; Wang, Longling; et al, Journal of Medicinal Chemistry, 2022, 65(23), 15710-15724

合成路线：1 步

7260-94-8

_100%

反应条件：

1.1 Reagents: Thionyl chloride ; 3 h, reflux

参考文献：

Design, synthesis and biological evaluation of dual acetylcholinesterase and phosphodiesterase 5A inhibitors in treatment for Alzheimer's disease

Zhou, Li-yun; Zhu, Yao; Jiang, Yu-ren; Zhao, Xiong-jie; Guo, Dong, Bioorganic & Medicinal Chemistry Letters, 2017, 27(17), 4180-4184

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane

参考文献：

Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo

Xu, Xiaoli; Wu, Yue; Hu, Mingyang; Li, Xiang; Bao, Qichao; et al, Scientific Reports, 2016, 6,

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Sodium hydroxide ; 2 min, heated

参考文献：

A novel and efficient strategy for the synthesis of various carbamates using carbamoyl chlorides under solvent-free and grinding conditions using microwave irradiation

Zare, Hassan; Ghanbari, Mohammad Mehdi; Jamali, Marzieh; Aboodi, Abdollah, Chinese Chemical Letters, 2012, 23(8), 883-886

合成路线：1 步

2757-23-5

_88%

反应条件：

1.1 Solvents: Dichloromethane ; 40 °C; 3 h, reflux; reflux → rt
1.2 Reagents: Chlorine ; 140 min, rt

参考文献：

An improved one-pot cost-effective synthesis of N,N-disubstituted carbamoyl halides and derivatives

Adeppa, K.; Rupainwar, D. C.; Misra, Krishna, Canadian Journal of Chemistry, 2010, 88(12), 1277-1280

合成路线：1 步

137-26-8

_86%

反应条件：

1.1 Reagents: Chlorine Solvents: Dichloromethane ; 6 h, 24 - 26 °C; 20 min
1.2 Reagents: Sodium bicarbonate Solvents: Water ; 2 - 3 h

参考文献：

Development of an improved method for conversion of thiuram disulfides into N,N-dialkylcarbamoyl halides and derivatives

Adeppa, K.; Rupainwar, D. C.; Misra, Krishna, Synthetic Communications, 2011, 41(2), 285-290

合成路线：1 步

_85%

参考文献：

Reactivity of thionyl chloride

Cardillo, Paolo, Chimica e l'Industria (Milan), 1992, 74(12),

合成路线：1 步

44365-46-0

15181-48-3

_80%

参考文献：

Synthesis and properties of (N,N-dimethyl)dichloromethaniminium chlorosulfate

Kukhar, V. P.; Pasternak, V. I.; Shevchenko, M. V., Zhurnal Organicheskoi Khimii, 1978, 14(9), 1841-6

合成路线：1 步

_69%

反应条件：

1.1 Reagents: Sulfur dichloride Solvents: Dichloromethane , Pyridine

参考文献：

Chemistry of sulfur chlorides. II. Reaction of sulfur dichloride, disulfur dichloride, and sulfuryl chloride with (thio)amides to yield (thio)carbamoyl chlorides and mustard oils

Hasserodt, Ulrich, Chemische Berichte, 1968, 101(1), 113-20

合成路线：1 步

67-56-1

108-24-7

_67%

反应条件：

1.1 Reagents: Copper carbonate , Copper oxide (CuO) Solvents: Water
1.2 Solvents: Acetone , Water
1.3 Reagents: Hydrogen sulfide Solvents: Water
1.4 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol
1.5 Reagents: Hydrochloric acid Solvents: Water
1.6 Catalysts: L-Ornithine , 2-Bromo-4-methyl-1-nitrobenzene Solvents: Acetic acid

参考文献：

A Comprehensive Study of the Active Site Residues of DT-Diaphorase: Rational Design of Benzimidazolediones as DT-Diaphorase Substrates

Suleman, Ali; Skibo, Edward B., Journal of Medicinal Chemistry, 2002, 45(6), 1211-1220

合成路线：1 步

_67%

反应条件：

1.1 Reagents: Thionyl chloride

参考文献：

Preparation of carbamoyl chlorides (bromides) by reactions of phosphorus trichloride (bromide) and thionyl chloride (bromide) with formamides

Schindler, Norbert; Ploeger, Walter, Chemische Berichte, 1971, 104(3), 969-71

合成路线：1 步

_56%

反应条件：

1.1 Catalysts: Sodium hydroxide Solvents: Benzene , Xylene , Water ; rt; 30 min, 70 °C

参考文献：

New aminoporphyrins bearing urea derivative substituents: synthesis, characterization, antibacterial and antifungal activity

Karimipour, Gholamreza; Kowkabi, Saeed; Naghiha, Asghar, Brazilian Archives of Biology and Technology, 2015, 58(3), 431-442

合成路线：1 步

_51%

反应条件：

1.1 Reagents: Sulfur dichloride Solvents: Carbon tetrachloride

参考文献：

Method for the preparation of carbamoyl chlorides and process for their utilization in the preparation of substituted monoarylureas

, Spain, , ,

合成路线：1 步

_50%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Dichloromethane ; rt → 0 °C
1.2 Solvents: Dichloromethane ; < 0 °C; 0 °C → rt; 6 - 8 h, rt

参考文献：

Synthesis and biological evaluation of genistein carbamate derivatives

Qiang, Xiaoming; Yuan, Wen; Sang, Zhipei; Deng, Yong, Youji Huaxue, 2013, 33(3), 621-629

合成路线：1 步

_50%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Dichloromethane ; 0.5 h, -10 °C; -10 °C → rt; 6 - 8 h, rt

参考文献：

Synthesis of pterostilbene and resveratrol carbamate derivatives as potential dual cholinesterase inhibitors and neuroprotective agents

Yuan, Wen; Shang, Zhipei; Qiang, Xiaoming; Tan, Zhenghuai; Deng, Yong, Research on Chemical Intermediates, 2014, 40(2), 787-800

合成路线：1 步

687-48-9

_46%

反应条件：

1.1 Reagents: Phosphorus oxychloride Solvents: Acetonitrile

参考文献：

A convenient preparation of certain N,N-dialkylcarbamoyl chlorides

Hoshino, Osamu; Saito, Keiji; Ishizaki, Miyuki; Umezawa, Bunsuke, Synthetic Communications, 1987, 17(16), 1887-92

合成路线：1 步