79607-22-0 (6-氯-1,4-二氢-4-氧代喹啉-3-羧酸乙酯,Ethyl 6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate)

_98%

反应条件：

1.1 Solvents: Diphenyl ether ; rt → reflux; reflux; 5 min, reflux; 2 h, reflux; reflux → rt

参考文献：

Preparation of 4-quinolinone and 1,4-benzothiazine derivatives as sedatives and hypnotics

, China, , ,

合成路线：1 步

_88%

反应条件：

1.1 Solvents: Diphenyl ether ; 2 h, 240 - 250 °C

参考文献：

A green and efficient synthetic methodology towards the synthesis of 1-allyl-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives

Gill, Muhammad Shoaib Ali; Azzman, Nursyuhada; Hassan, Sharifah Syed; Shah, Syed Adnan Ali; Ahemad, Nafees, BMC Chemistry, 2022, 16(1),

合成路线：1 步

_88%

反应条件：

1.1 Solvents: 1,1′-Biphenyl, mixt. with 1,1′-oxybis[benzene] ; reflux

参考文献：

Synthesis and anti-HSV-1 activity of quinolonic acyclovir analogs

Lucero, Bianca d'A.; Gomes, Claudia Regina B.; Frugulhetti, Izabel Christina de P. P.; Faro, Leticia V.; Alvarenga, Lise; et al, Bioorganic & Medicinal Chemistry Letters, 2006, 16(4), 1010-1013

合成路线：1 步

1462-12-0

_87%

反应条件：

1.1 Solvents: Diphenyl ether ; 1 min, 80 °C; 2 min, 240 °C

参考文献：

Microwave assisted synthesis of ethyl quinolon-4-one-3-carboxylates and hydrolysis to quinolon-4-one-3-carboxylic acids

Malvacio, Ivana; Vera, D. Mariano A.; Moyano, Elizabeth L., Current Microwave Chemistry, 2014, 1(1), 52-58

合成路线：1 步

87-13-8

_87%

反应条件：

1.1 Solvents: Ethanol ; 2 h, reflux
1.2 Solvents: 1,1′-Biphenyl, mixt. with 1,1′-oxybis[benzene] ; 30 min, reflux

参考文献：

Synthesis and anti-HSV-1 Activity of 1,4-dihydro-4-oxoquinoline Ribonucleosides

Canuto, Carla Veronica B. dos S.; Gomes, Claudia R. B.; Marques, Isakelly P.; Faro, Leticia V.; Santos, Fernanda da Costa; et al, Letters in Drug Design & Discovery, 2007, 4(6), 404-409

合成路线：1 步

_85%

反应条件：

1.1 Solvents: Diphenyl ether ; 275 °C

参考文献：

4-oxoquinoline-3-carboxamide acyclonucleoside phosphonates hybrids: Human MCF-7 breast cancer cell death induction by oxidative stress-promoting and in silico ADMET studies

Machado, Thayna R. ; Faro, Leticia V.; Mello, Angelica L. do Nascimento; Silva, David de O.; Abrahim-Vieira, Barbara de A.; et al, Journal of Molecular Structure, 2023, 1276,

合成路线：1 步

_85%

反应条件：

1.1 Solvents: Diphenyl ether ; 30 min, reflux

参考文献：

Synthesis, cytotoxicity and mechanistic evaluation of 4-oxoquinoline-3-carboxamide derivatives: finding new potential anticancer drugs

Forezi, Luana da S. M.; Tolentino, Nathalia M. C.; de Souza, Alessandra M. T.; Castro, Helena C.; Montenegro, Raquel C.; et al, Molecules, 2014, 19(5), 6651-6670

合成路线：1 步

_83%

反应条件：

1.1 Solvents: Diphenyl ether ; 2 h, reflux

参考文献：

Design, synthesis and 2D QSAR study of novel pyridine and quinolone hydrazone derivatives as potential antimicrobial and antitubercular agents

Abdelrahman, Mohamed A.; Salama, Ismail; Gomaa, Mohamed S.; Elaasser, Mahmoud M.; Abdel-Aziz, Marwa M.; et al, European Journal of Medicinal Chemistry, 2017, 138, 698-714

合成路线：1 步

_83%

反应条件：

1.1 Solvents: Diphenyl ether ; 1 h, reflux

参考文献：

Pharmacomodulations around the 4-Oxo-1,4-dihydroquinoline-3-carboxamides, a Class of Potent CB2-Selective Cannabinoid Receptor Ligands: Consequences in Receptor Affinity and Functionality

Stern, Eric; Muccioli, Giulio G.; Bosier, Barbara; Hamtiaux, Laurie; Millet, Regis; et al, Journal of Medicinal Chemistry, 2007, 50(22), 5471-5484

合成路线：1 步

87-13-8

_75%

参考文献：

Microwave assisted Gould-Jacob reaction: Synthesis of 4-quinolones under solvent free conditions

Dave, Chaitanya G.; Joshipura, Hardik M., Indian Journal of Chemistry, 2002, (3), 650-652

合成路线：1 步

_74%

反应条件：

1.1 24 h, 130 °C
1.2 Reagents: Diphenyl ether ; 45 min, reflux

参考文献：

Three-Component One-Pot Approach to Highly Efficient and Sustainable Synthesis of the Functionalized Quinolones via Linear/Branched Domino Protocols, Key Synthetic Methods for the Floxacin of Quinolone Drugs

Bai, Hairui; Liu, Fujun; Wang, Xiaojing; Wang, Ping; Huang, Chao, ACS Omega, 2018, 3(9), 11233-11251

合成路线：1 步

_70%

反应条件：

1.1 Solvents: Diphenyl ether ; 250 °C

参考文献：

Quinolone-N-acylhydrazone hybrids as potent Zika and Chikungunya virus inhibitors

Marra, Roberta K. F.; Kummerle, Arthur E.; Guedes, Guilherme P.; Barros, Caroline de S.; Gomes, Rafaela S. P.; et al, Bioorganic & Medicinal Chemistry Letters, 2020, 30(2),

合成路线：1 步

3377-20-6

_68%

反应条件：

1.1 1 h, 120 °C; 120 °C → rt
1.2 Reagents: Methanesulfonic acid, mixt. with phosphorus oxide (P2O5) ; 1 h, 130 °C; 130 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

Conjugate Addition Routes to 2-Alkyl-2,3-dihydroquinolin-4(1H)-ones and 2-Alkyl-4-hydroxy-1,2-dihydroquinoline-3-carboxylates

Kingsbury, Alex; Brough, Steve; McCarthy, Antonio Pedrina; Lewis, William; Woodward, Simon, European Journal of Inorganic Chemistry, 2020, 2020(11-12), 1011-1017

合成路线：1 步

87-13-8

_66%