80-00-2 (4-氯二苯砜,4-Chlorophenyl phenyl sulfone)

反应条件：

1.1 Catalysts: Trifluoromethanesulfonic acid ; 24 h, 160 °C

参考文献：

Triflic-Acid-Catalyzed Friedel-Crafts Reaction for the Synthesis of Diaryl Sulfones

Falconnet, Alban ; Arndt, Jan-Dirk; Hashmi, A. Stephen K. ; Schaub, Thomas, European Journal of Organic Chemistry, 2022, 2022(26),

合成路线：1 步

108-90-7

98-09-9

_100%

反应条件：

1.1 Catalysts: Indium triflate
1.2 Reagents: Hydrochloric acid Solvents: Dichloromethane , Water

参考文献：

Indium-catalyzed aryl and alkyl sulfonylation of aromatics

Frost, Christopher G.; Hartley, Joseph P.; Whittle, Alan J., Synlett, 2001, (6), 830-832

合成路线：1 步

88284-48-4

1142-97-8

_98%

反应条件：

1.1 Reagents: Cesium fluoride Solvents: Acetonitrile ; 3 h, rt

参考文献：

Facile Synthesis of Diaryl Sulfones through Arylsulfonylation of Arynes and Thiosulfonates

Zheng, Yating; Tang, Delin; Xie, Pei; Luo, Jinyun; Cai, Zhihua; et al, Synthesis, 2023, 55(8), 1253-1259

合成路线：1 步

_96%

反应条件：

1.1 Solvents: Dimethylformamide ; 24 h, 90 °C

参考文献：

Metal-free synthesis of diaryl sulfones from arylsulfinic acid salts and diaryliodonium salts

Umierski, Natalie; Manolikakes, Georg, Organic Letters, 2013, 15(1), 188-191

合成路线：1 步

98-80-6

_95%

反应条件：

1.1 Reagents: 1,4-Diazoniabicyclo[2.2.2]octane, 1,4-disulfino-, bis(inner salt) Catalysts: Iron oxide (Fe3O4) , 1-[2-(Methylthio)phenyl]ethanone (reaction products with 3-(Trimethoxysilyl)propylamine, silica functionalized) , Silica , Aminopropyltrimethoxysilane (reaction products with o-(Methylthio)acetophenone, silica functionalized) , Cu2+ Solvents: Dimethylformamide ; 10 h, 140 °C

参考文献：

Fabrication and Characterization of Copper (II) Complex Supported on Magnetic Nanoparticles as a Green and Efficient Nanomagnetic Catalyst for Synthesis of Diaryl Sulfones

Abdelbasset, Walid Kamal; Mohsen, Ahmed M.; Kadhim, Mustafa M.; Alkaim, Ayad F.; Fakri Mustafa, Yasser, Polycyclic Aromatic Compounds, 2023, 43(5), 4032-4044

合成路线：1 步

14752-66-0

780-69-8

_94%

反应条件：

1.1 Reagents: Oxygen , Potassium fluoride Catalysts: Dabco , Cuprous iodide Solvents: Dimethylacetamide ; 6 h, 80 °C

参考文献：

Cu-catalyzed coupling of arylsulfinic salts with arylsilanes under mild conditions

Yang, Xiaomin; Cao, Yanyan; Li, Enbo; Zhang, Pengmei; Hou, Zhanzhong, Applied Organometallic Chemistry, 2014, 28(10), 785-788

合成路线：1 步

873-55-2

_93%

反应条件：

1.1 Reagents: Cesium carbonate Catalysts: Copper Solvents: Dimethyl sulfoxide ; rt; 24 h, rt → 110 °C

参考文献：

Efficient Ullmann C-X coupling reaction catalyzed by a recoverable functionalized-chitosan supported copper complex

Liu, Xuemin; Chang, Shuo; Chen, Xinzhi; Ge, Xin; Qian, Chao, New Journal of Chemistry, 2018, 42(19), 16013-16020

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Aqua(N,N,N′,N′,N′′,N′′-hexamethylphosphoric triamide-κO)oxodiperoxymolybdenum Solvents: Tetrahydrofuran ; 1.5 h, 65 - 70 °C

参考文献：

Oxidation of chalcogenides using the peroxo complex of molybdenum [MoO(O2)2(H2O)(hmpa)], hmpa = hexamethylphosphoramide

Khurana, Jitender M.; Agrawal, Arpita; Kumar, Sanjay, Journal of the Brazilian Chemical Society, 2009, 20(7), 1256-1261

合成路线：1 步

4547-68-6

71-43-2

_90%

反应条件：

1.1 Reagents: Trifluoromethanesulfonic acid Solvents: Dichloromethane ; 3 h, rt
1.2 Reagents: Water ; rt

参考文献：

Regiospecific Cleavage of S-N Bonds in Sulfonyl Azides: Sulfonyl Donors

Zhang, Zhiguo ; Wang, Songnan; Zhang, Yong; Zhang, Guisheng, Journal of Organic Chemistry, 2019, 84(7), 3919-3926

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: 1-Propanol ; 18 h, 100 °C

参考文献：

Base-promoted synthesis of diarylsulfones from sulfonyl hydrazines and diaryliodonium salts

Gong, Bozhen; Zhu, Haibo; Yang, Liu; Wang, Haifeng; Fan, Qiangwen; et al, Organic & Biomolecular Chemistry, 2022, 20(17), 3501-3505

合成路线：1 步

515-42-4

_87%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: N,N′-Dimethylethylenediamine , Cupric acetate Solvents: Dimethyl sulfoxide ; rt → 110 °C; 2 h, 110 °C

参考文献：

Mechanistic aspects of copper (II)-catalyzed synthesis of sulfones from sulfinate salts and aryl halides under C-S coupling

Ge, Xin; Sun, Fengli; Liu, Xuemin; Chen, Xinzhi; Qian, Chao; et al, Molecular Catalysis, 2018, 449, 72-78

合成路线：1 步

153766-81-5

14752-66-0

_87%

反应条件：

1.1 Reagents: Sodium acetate , Oxygen Catalysts: Cuprous iodide Solvents: 1,2-Dichloroethane ; 3 h, 25 °C

参考文献：

Diaryl sulfones synthesis with aryltrifluoroborates and aryl sulfinic salts under mild conditions

Zhang, Wei; Li, Ke; Zhao, Baoli, Journal of Chemical Research, 2014, 38(5), 269-271

合成路线：1 步

14752-66-0

591-50-4

_86%

反应条件：

1.1 Catalysts: Cupric acetate , 2747892-13-1 Solvents: Water ; 7 h, 100 °C

参考文献：

Interfacing sugar-based surfactant micelles and Cu nanoparticles: a nanoreactor for C-S coupling reactions in water

Ge, Xin; Song, Weili; He, Xi; Yang, Jinguo; Qian, Chao; et al, Green Chemistry, 2021, 23(17), 6322-6329

合成路线：1 步

_86%

反应条件：

1.1 Reagents: Oxygen Solvents: Diethylene glycol dibutyl ether ; 20 h, 150 °C

参考文献：

Oxidation of aromatic sulfides with molecular oxygen: Controllable synthesis of sulfoxides or sulfones

Tang, Lili; Du, Kejie; Yu, Bing; He, Liangnian, Chinese Chemical Letters, 2020, 31(12), 2991-2992

合成路线：1 步

_86%

反应条件：

1.1 Reagents: Oxygen Solvents: Diethylene glycol dibutyl ether ; rt; 20 h, 150 °C

参考文献：

Selective oxidation of (hetero)sulfides with molecular oxygen under clean conditions

Liu, Kai-Jian; Deng, Ji-Hui; Yang, Jie; Gong, Shao-Feng; Lin, Ying-Wu; et al, Green Chemistry, 2020, 22(2), 433-438

合成路线：1 步

873-55-2

_86%

反应条件：

1.1 Reagents: Potassium acetate Catalysts: Glucosamine hydrochloride , Cuprous iodide Solvents: Dimethyl sulfoxide , Water ; 24 h, rt → 100 °C

参考文献：

D-Glucosamine as a green ligand for copper catalyzed synthesis of aryl sulfones from aryl halides and sodium sulfinates

Yang, Ming; Shen, Hongyun; Li, Yuanyuan; Shen, Chao; Zhang, Pengfei, RSC Advances, 2014, 4(50), 26295-26300

合成路线：1 步

_84%