80353-26-0 (他唑巴坦,6-Bromo-3,3-dimethyl-7-oxo-4-oxide-4-thia-1-azabicyclo3.2.0heptane-2-carboxylic Acid Diphenylmethyl Ester)

反应条件：

1.1 Reagents: Hydrogen peroxide Solvents: Phenol , Water ; 25 °C
1.2 Reagents: Sodium sulfite Solvents: Water ; rt
1.3 Reagents: Sodium hydroxide Solvents: Water ; neutralized, rt

参考文献：

A new approach to the synthesis of tazobactam using an organosilver compound

Xu, Wei Liang; et al, Synthesis, 2005, (3), 442-446

合成路线：1 步

74189-25-6

_97%

反应条件：

1.1 Reagents: Peracetic acid Solvents: Water ; 1 min, 25 °C

参考文献：

Application of Continuous Flow in Tazobactam Synthesis

Zhou, Shuhao; et al, Organic Process Research & Development, 2021, 25(7), 1648-1657

合成路线：1 步

74189-25-6

反应条件：

1.1 Reagents: Hydrogen peroxide Solvents: Water

参考文献：

Precise Preparation of a High-Purity Key Intermediate of Tazobactam

Zhou, Yanan; et al, Organic Process Research & Development, 2020, 24(12), 2898-2905

合成路线：1 步

91922-15-5

61765-84-2

_97%

反应条件：

1.1 Reagents: Hydrogen peroxide Solvents: Water ; 1 h, rt

参考文献：

Synthesis of benzhydryl S-oxopenicillanate

Xu, Wei-liang; et al, Jingxi Huagong, 2003, 20(11), 700-701

合成路线：1 步

_91%

反应条件：

1.1 Solvents: Dichloromethane ; 0 °C
1.2 Reagents: Iodine Solvents: Dichloromethane
1.3 Reagents: Alumina , Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Solvents: Water ; 30 min, 0 °C; 3 h, 0 °C

参考文献：

Synthesis of Tazobactam, β-lactamase inhibitor

Li, Yang; et al, Transactions of Tianjin University, 2002, 8(1), 33-36

合成路线：1 步

反应条件：

1.1 Reagents: Peracetic acid , Potassium iodide Solvents: Dichloromethane , Water ; 1 h, 0 °C

参考文献：

Crystal structures of KPC-2 β-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226

Ke, Wei; et al, Antimicrobial Agents and Chemotherapy, 2012, 56(5), 2713-2718

合成路线：1 步

反应条件：

1.1 Reagents: Peracetic acid Solvents: Chloroform , Water
1.2 Reagents: Potassium iodide
1.3 Reagents: Peracetic acid Solvents: Water
1.4 Reagents: Sulfuric acid Solvents: Water

参考文献：

Synthesis of 2β-azidomethylpenicillin 1,1-dioxides and 3β-azido-3α-methylcepham 1,1-dioxides

Micetich, Ronald G.; et al, Synthesis, 1986, (4), 292-6

合成路线：2 步

883-40-9

反应条件：

1.1 Solvents: Methanol , Dichloromethane ; 2 h, 0 °C
2.1 Reagents: Hydrogen peroxide Solvents: Water

参考文献：

Precise Preparation of a High-Purity Key Intermediate of Tazobactam

Zhou, Yanan; et al, Organic Process Research & Development, 2020, 24(12), 2898-2905

合成路线：2 步

91-01-0

反应条件：

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 1 min, 25 °C
1.2 Reagents: Ethylenediaminetetraacetic acid , Acetic acid , Sulfuric acid , Hydrogen peroxide Solvents: Water ; 10 min, 55 °C
2.1 Reagents: Peracetic acid Solvents: Water ; 1 min, 25 °C

参考文献：

Application of Continuous Flow in Tazobactam Synthesis

Zhou, Shuhao; et al, Organic Process Research & Development, 2021, 25(7), 1648-1657

合成路线：2 步

91-01-0

反应条件：

1.1 Reagents: Dicyclohexylcarbodiimide Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; rt
2.1 Reagents: Hydrogen peroxide Solvents: Phenol , Water ; 25 °C
2.2 Reagents: Sodium sulfite Solvents: Water ; rt
2.3 Reagents: Sodium hydroxide Solvents: Water ; neutralized, rt

参考文献：

A new approach to the synthesis of tazobactam using an organosilver compound

Xu, Wei Liang; et al, Synthesis, 2005, (3), 442-446

合成路线：3 步