80601-69-0 (4-羟基-6-(3-吡啶)-2H-吡喃-2-酮,2H-Pyran-2-one, 4-hydroxy-6-(3-pyridinyl)-)

快速询单

结构式：

4-羟基-6-(3-吡啶)-2H-吡喃-2-酮MOL文件

CAS号：

80601-69-0

中文名称：

4-羟基-6-(3-吡啶)-2H-吡喃-2-酮

英文名称：

2H-Pyran-2-one, 4-hydroxy-6-(3-pyridinyl)-

分子式：

C₁₀H₇NO₃

分子量：

189.167482614517

4-羟基-6-(3-吡啶)-2H-吡喃-2-酮(80601-69-0)名称与标识符

名称

中文别名：

4-羟基-6-(3-吡啶)-2H-吡喃-2-酮;

英文别名：

2H-Pyran-2-one, 4-hydroxy-6-(3-pyridinyl)-;4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one;4-hydroxy-6-pyridin-3-ylpyran-2-one;2,4-Pentadienoic acid, 3,5-dihydroxy-5-(3-pyridyl)-, δ-lactone (6CI);4-Hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (ACI);

标识符

InChIKey：

HWOWEGAQDKKHDR-UHFFFAOYSA-N

Inchi：

1S/C10H7NO3/c12-8-4-9(14-10(13)5-8)7-2-1-3-11-6-7/h1-6,12H

SMILES：

O=C1C=C(O)C=C(C2C=CC=NC=2)O1

4-羟基-6-(3-吡啶)-2H-吡喃-2-酮(80601-69-0)推荐厂家更多厂家(1)

公司名称	手机号/电话	联系人	QQ	微信	询单
深圳爱拓化学有限公司	13417589054	肖小姐	2644020535		询单

4-羟基-6-(3-吡啶)-2H-吡喃-2-酮(80601-69-0)合成路线

合成路线：1 步

919198-58-6

_96%

80601-69-0

反应条件：

1.1 Reagents: Trifluoroacetic acid , Trifluoroacetic anhydride ; -20 °C; -20 °C → 0 °C; 2 h, 0 °C
1.2 Reagents: Water ; 0 °C; 12 h, 4 °C

参考文献：

Synthesis of the bis-potassium salts of 5-hydroxy-3-oxopent-4-enoic acids and their use for the efficient preparation of 4-hydroxy-2H-pyran-2-ones and other heterocycles

Schmidt, Dietmar; et al, Chemical Communications (Cambridge, 2006, (45), 4732-4734

合成路线：1 步

1812187-88-4

_80%

80601-69-0

反应条件：

1.1 Solvents: Hexane ; 30 min, reflux

参考文献：

Asymmetric Total Synthesis of ent-Pyripyropene A

Fuse, Shinichiro; et al, Chemistry - A European Journal, 2015, 21(26), 9454-9460

合成路线：1 步

141-97-9

614-18-6

80601-69-0

反应条件：

1.1 Reagents: N,N,N′,N′-Tetramethylethylenediamine , Lithium diisopropylamide Solvents: Diethyl ether
1.2 heated

参考文献：

Synthesis, molecular targets, and antitumor activities of substituted tetrahydro-1-oxopyrano[4,3-b][1]benzopyrans and nanogels for drug delivery

Perchellet, Elisabeth M.; et al, Anti-Cancer Agents in Medicinal Chemistry, 2009, 9(8), 864-876

合成路线：1 步

343947-60-4

80601-69-0

反应条件：

1.1 Catalysts: 1,1′-Carbonyldiimidazole

参考文献：

Use of β-ketocarboxylic acids for syntheses of 6-substituted 4-hydroxy-2-pyrones and acyclic β-diketones

Ohta, Shunsaku; et al, Chemical & Pharmaceutical Bulletin, 1981, 29(10), 2762-8

合成路线：2 步

144223-30-3

5394-63-8

80601-69-0

反应条件：

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran , Hexane ; -78 °C
1.2 30 min, 0 °C
1.3 Solvents: Tetrahydrofuran ; -78 °C; 15 h, 0 °C
1.4 Reagents: Sodium bicarbonate , Ammonium chloride Solvents: Water ; 0 °C
2.1 Solvents: Hexane ; 30 min, reflux

参考文献：

Asymmetric Total Synthesis of ent-Pyripyropene A

Fuse, Shinichiro; et al, Chemistry - A European Journal, 2015, 21(26), 9454-9460

合成路线：2 步

194937-71-8

86969-13-3

80601-69-0

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Ethanol ; 30 min, rt; 12 h, -20 °C
2.1 Reagents: Trifluoroacetic acid , Trifluoroacetic anhydride ; -20 °C; -20 °C → 0 °C; 2 h, 0 °C
2.2 Reagents: Water ; 0 °C; 12 h, 4 °C

参考文献：

Synthesis of the bis-potassium salts of 5-hydroxy-3-oxopent-4-enoic acids and their use for the efficient preparation of 4-hydroxy-2H-pyran-2-ones and other heterocycles

Schmidt, Dietmar; et al, Chemical Communications (Cambridge, 2006, (45), 4732-4734

合成路线：2 步

4111-54-0

3594-37-4

80601-69-0

反应条件：

1.1 Catalysts: Carbon dioxide
2.1 Catalysts: 1,1′-Carbonyldiimidazole

参考文献：

Use of β-ketocarboxylic acids for syntheses of 6-substituted 4-hydroxy-2-pyrones and acyclic β-diketones

Ohta, Shunsaku; et al, Chemical & Pharmaceutical Bulletin, 1981, 29(10), 2762-8

合成路线：3 步

141-97-9

919198-16-6

80601-69-0

反应条件：

1.1 Reagents: Diisopropylamine , Butyllithium Solvents: Tetrahydrofuran ; 30 min, -10 °C; 30 min, -10 °C; -10 °C → -78 °C
1.2 Solvents: Tetrahydrofuran ; -78 °C → 0 °C; 10 min, 0 °C
1.3 Solvents: Tetrahydrofuran ; 3 h, 0 °C
1.4 -20 °C
2.1 Reagents: Potassium hydroxide Solvents: Ethanol ; 30 min, rt; 12 h, -20 °C
3.1 Reagents: Trifluoroacetic acid , Trifluoroacetic anhydride ; -20 °C; -20 °C → 0 °C; 2 h, 0 °C
3.2 Reagents: Water ; 0 °C; 12 h, 4 °C

参考文献：

Synthesis of the bis-potassium salts of 5-hydroxy-3-oxopent-4-enoic acids and their use for the efficient preparation of 4-hydroxy-2H-pyran-2-ones and other heterocycles

Schmidt, Dietmar; et al, Chemical Communications (Cambridge, 2006, (45), 4732-4734

合成路线：4 步

10400-19-8

75-55-8

80601-69-0

反应条件：

1.1 -
2.1 Reagents: Diisopropylamine , Butyllithium Solvents: Tetrahydrofuran ; 30 min, -10 °C; 30 min, -10 °C; -10 °C → -78 °C
2.2 Solvents: Tetrahydrofuran ; -78 °C → 0 °C; 10 min, 0 °C
2.3 Solvents: Tetrahydrofuran ; 3 h, 0 °C
2.4 -20 °C
3.1 Reagents: Potassium hydroxide Solvents: Ethanol ; 30 min, rt; 12 h, -20 °C
4.1 Reagents: Trifluoroacetic acid , Trifluoroacetic anhydride ; -20 °C; -20 °C → 0 °C; 2 h, 0 °C
4.2 Reagents: Water ; 0 °C; 12 h, 4 °C

参考文献：

Synthesis of the bis-potassium salts of 5-hydroxy-3-oxopent-4-enoic acids and their use for the efficient preparation of 4-hydroxy-2H-pyran-2-ones and other heterocycles

Schmidt, Dietmar; et al, Chemical Communications (Cambridge, 2006, (45), 4732-4734