80783-98-8 (N-甲氧基-N-甲基-环己基酰胺,N-methoxy-N-methylcyclohexanecarboxamide)

_100%

反应条件：

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane ; rt; 1 h, rt
1.2 16 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Enolizable β-Fluoroenones: Synthesis and Asymmetric 1,2-Reduction

Zygalski, Lukas; et al, Organic Letters, 2018, 20(16), 5071-5074

合成路线：1 步

_97%

反应条件：

1.1 Solvents: Toluene ; 10 min, 0 °C
1.2 Reagents: Phosphorus trichloride Solvents: Toluene ; 0 °C; 0 °C → rt; 0.5 h, 60 °C; 60 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

One-pot transition-metal-free synthesis of Weinreb amides directly from carboxylic acids

Niu, Teng; et al, Synthesis, 2014, 46(3), 320-330

合成路线：1 步

反应条件：

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; rt; 1 h, rt
1.2 16 h, rt

参考文献：

Asymmetric alkene-alkene reductive cross-coupling reaction via visible-light photoredox/cobalt dual catalysis

Maiti, Mamata; et al, Chemical Communications (Cambridge, 2023, 59(64), 9718-9721

合成路线：1 步

4630-82-4

_99%

反应条件：

1.1 Solvents: Tetrahydrofuran ; rt; rt → -20 °C
1.2 Reagents: Chloro(1-methylethyl)magnesium ; 15 min, -20 °C; 10 h, -20 °C
1.3 Reagents: Ammonium chloride Solvents: Diethyl ether , Water

参考文献：

Copper(I)-Catalyzed Enantioselective Nucleophilic Borylation of Aliphatic Ketones: Synthesis of Enantioenriched Chiral Tertiary α-Hydroxyboronates

Kubota, Koji ; et al, Angewandte Chemie, 2017, 56(23), 6646-6650

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Diethyl ether , Water ; 2 min, 0 °C; 1 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Three-Step Synthetic Pathway toward Fully Decorated [1,2,3]Triazolo[4,5-d]pyrimidine (8-Azapurine) Derivatives

Reniers, Felien ; et al, Organic Letters, 2023, 25(16), 2820-2824

合成路线：1 步

_95%

反应条件：

1.1 Solvents: Dichloromethane ; rt → 0 °C
1.2 Reagents: Triethylamine ; 0 °C → 10 °C; 10 °C → 0 °C
1.3 < 7 °C; 65 h, rt
1.4 Solvents: Water ; rt

参考文献：

Reactions between Weinreb Amides and 2-Magnesiated Oxazoles: A Simple and Efficient Preparation of 2-Acyl Oxazoles

Pippel, Daniel J.; et al, Journal of Organic Chemistry, 2007, 72(15), 5828-5831

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; cooled; 17 h, rt

参考文献：

Catalytic enantioselective construction of β-quaternary carbons via a conjugate addition of cyanide to β,β-disubstituted α,β-unsaturated carbonyl compounds

Tanaka, Yuta; et al, Journal of the American Chemical Society, 2010, 132(26), 8862-8863

合成路线：1 步

30289-28-2

_97%

反应条件：

1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Acetonitrile

参考文献：

An efficient synthesis of N-methoxy-N-methylamides from carboxylic acids using N-methoxy-N-methylcarbamoyl chloride

Lee, Jae In; et al, Bulletin of the Korean Chemical Society, 2002, 23(3), 521-524

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Triethylamine , Diphosgene Solvents: Dichloromethane ; 0 °C
1.2 0 °C → rt

参考文献：

An efficient one-pot synthesis of N-methoxy-N-methylamides from carboxylic acids

Kim, Misoo; et al, Synthetic Communications, 2003, 33(23), 4013-4018

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane
1.2 Reagents: Tributylphosphine , Dipyrithione

参考文献：

A mild, one-pot method for the conversion of carboxylic acids into the corresponding Weinreb amides

Banwell, Martin; et al, Synthetic Communications, 2001, 31(13), 2011-2019

合成路线：1 步

_94%

反应条件：

1.1 Reagents: 4-(Dimethylamino)pyridine , S,S-Di-2-pyridinyl carbonodithioate Solvents: Acetonitrile
1.2 Reagents: Triethylamine
1.3 Solvents: Tetrahydrofuran
1.4 Solvents: Hexane , Ethyl acetate

参考文献：

A convenient synthesis of N-methoxy-N-methylamides from carboxylic acids using S,S-di-2-pyridyl dithiocarbonate

Lee, Jae In; et al, Bulletin of the Korean Chemical Society, 2001, 22(4), 421-423

合成路线：1 步

1062512-43-9

_95%

反应条件：

1.1 Solvents: Toluene ; 0.5 - 1 h, 60 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

A powerful reagent for synthesis of Weinreb amides directly from carboxylic acids

Niu, Teng; et al, Organic Letters, 2009, 11(19), 4474-4477

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; rt → 0 °C; 0 °C
1.2 1 h, 0 °C

参考文献：

A new synthesis of cyclohexyl-3-fluorobenzylone

Zhou, Xiao-ping; et al, Fenzi Kexue Xuebao, 2005, 21(2), 60-62

合成路线：1 步

参考文献：

N-Methoxy-N-methylamides as effective acylating agents

Nahm, Steven; et al, Tetrahedron Letters, 1981, 22(39), 3815-18

合成路线：1 步

4630-82-4

_94%

反应条件：

1.1 Reagents: Chloro(1-methylethyl)magnesium Solvents: Tetrahydrofuran

参考文献：

A new general method for preparation of N-methoxy-N-methylamides. Application in direct conversion of an ester to a ketone

Williams, J. Michael; et al, Tetrahedron Letters, 1995, 36(31), 5461-4

合成路线：1 步

4630-82-4

_62%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; 25 min, 22 °C
1.2 Reagents: [μ-(1,4-Diazabicyclo[2.2.2]octane-κN1:κN4)]hexamethyldialuminum Solvents: Tetrahydrofuran ; 16 min, 130 °C
1.3 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Microwave acceleration in DABAL-Me3-mediated amide formation

Glynn, Daniel; et al, Tetrahedron Letters, 2008, 49(39), 5687-5688

合成路线：1 步

1020441-41-1

931-51-1

_87%

反应条件：

1.1 Solvents: Tetrahydrofuran ; rt; 15 min, -15 °C; 5 min, -15 °C
1.2 Reagents: Ammonium chloride Solvents: Water

参考文献：

A novel synthesis of N-methoxy-N-methylamides from 4,6-pyrimidyl urethane and Grignard reagents

Lee, Jae In, Bulletin of the Korean Chemical Society, 2007, 28(4), 695-697

合成路线：1 步

912457-54-6

931-51-1

_84%

反应条件：

1.1 Solvents: Tetrahydrofuran ; rt → 0 °C; 10 min, 0 °C; 0.5 h, 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

参考文献：

A new synthesis of N-methoxy-N-methylamides from S-2-pyridyl thiocarbamate and Grignard reagents

Lee, Jae In; et al, Journal of the Korean Chemical Society, 2005, 49(6), 609-612

合成路线：1 步

2043-61-0

_72%

反应条件：

1.1 Reagents: Pivalic acid , Pyridine , tert-Butyl hypochlorite Catalysts: Tempo Solvents: Acetonitrile ; 20 min, 0 °C; 1 h
1.2 25 °C

参考文献：

Organocatalytic oxidation of aldehydes to mixed anhydrides

Toledo, Hila; et al, Chemical Communications (Cambridge, 2013, 49(39), 4367-4369

合成路线：2 步

反应条件：

1.1 Reagents: N,O-Dimethylhydroxylamine hydrochloride , Phosphorus trichloride Solvents: Diethyl ether ; 0 °C; 0 °C → rt; overnight, rt; 4 h, reflux
2.1 Solvents: Toluene ; 0.5 - 1 h, 60 °C
2.2 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

A powerful reagent for synthesis of Weinreb amides directly from carboxylic acids

Niu, Teng; et al, Organic Letters, 2009, 11(19), 4474-4477

合成路线：2 步

30289-28-2

1193-24-4

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 48 h, rt
2.1 Solvents: Tetrahydrofuran ; rt; 15 min, -15 °C; 5 min, -15 °C
2.2 Reagents: Ammonium chloride Solvents: Water

参考文献：

A novel synthesis of N-methoxy-N-methylamides from 4,6-pyrimidyl urethane and Grignard reagents

Lee, Jae In, Bulletin of the Korean Chemical Society, 2007, 28(4), 695-697

合成路线：2 步

55277-90-2