80826-86-4 (3,5-二甲基-4-碘苯酚,3,5-Dimethyl-4-iodophenol)

_90%

反应条件：

1.1 Reagents: Iodine , Oxygen Catalysts: Cupric nitrate Solvents: Water ; 1 atm, rt; 2.5 h, 80 °C

参考文献：

A green catalytic method for selective synthesis of iodophenols via aerobic oxyiodination under organic solvent-free conditions

Xin, Hongchuan; Hu, Liangning; Yu, Jianqiang; Sun, Wenshou; An, Zengjian, Catalysis Communications, 2017, 93, 1-4

合成路线：1 步

_79%

反应条件：

1.1 Reagents: Hydrochloric acid , Potassium iodide , Potassium iodate Solvents: Methanol , Water

参考文献：

Stereospecific syntheses of 2-alkyl and 2-phenyl substituted 3-(2,6-dimethyl-4-hydroxyphenyl)propanoic acids

Lu, Yixin; Schiller, Peter W., Synthesis, 2001, (11), 1639-1644

合成路线：1 步

_79%

反应条件：

1.1 Reagents: Hydrochloric acid , Potassium iodide , Potassium iodate Solvents: Methanol

参考文献：

Stereospecific synthesis of (2S)-2-methyl-3-(2',6'-dimethyl-4'-hydroxyphenyl)propionic acid (Mdp) and its incorporation into an ****** peptide

Lu, Y.; Weltrowska, G.; Lemieux, C.; Chung, N. N.; Schiller, P. W., Bioorganic & Medicinal Chemistry Letters, 2001, 11(3), 323-325

合成路线：1 步

_78%

反应条件：

1.1 Reagents: Potassium iodide , Phosphonium, triphenyl(phenylmethyl)-, peroxymonosulfate (1:1) Solvents: Acetonitrile ; 1.5 h, rt

参考文献：

Highly selective iodination of phenols using potassium iodide and benzyltriphenylphosphonium peroxymonosulfate

Hajipour, Abdol Reza; Adibi, Hadi, Journal of Chemical Research, 2004, (4), 294-295

合成路线：1 步

_75%

反应条件：

1.1 Reagents: Iodine , Oxygen Catalysts: Sodium nitrite , Hydrochloric acid Solvents: 1,2-Dichloroethane , Water ; 8 h, 20 °C

参考文献：

Aerobic oxyiodination of activated aromatics using HCl/NaNO2/I2

Wang, Kaiyang; Wang, Xinliang; Zhang, Guofu; Liang, Xinmiao, Jingxi Huagong, 2009, 26(7), 715-719

合成路线：1 步

_72%

反应条件：

1.1 Reagents: Dimethyl sulfoxide , Sulfuric acid , Ammonium iodide Solvents: Ethyl acetate ; 60 °C; 6 h, 60 °C

参考文献：

Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization

Song, Song; Sun, Xiang; Li, Xinwei; Yuan, Yizhi; Jiao, Ning, Organic Letters, 2015, 17(12), 2886-2889

合成路线：1 步

_69%

反应条件：

1.1 Reagents: Hydrochloric acid , Potassium iodate Solvents: Methanol , Water ; 30 min, 0 °C

参考文献：

Modified o-methyl-substituted IBX: room temperature oxidation of alcohols and sulfides in common organic solvents

Moorthy, Jarugu Narasimha; Singhal, Nidhi; Senapati, Kalyan, Tetrahedron Letters, 2008, 49(1), 80-84

合成路线：1 步

_67%

反应条件：

1.1 Reagents: Calcium carbonate , Benzyltrimethylammonium dichloroiodate Solvents: Methanol , Dichloromethane

参考文献：

Halogenation using quaternary ammonium polyhalides. V. Iodination of phenols by use of benzyltrimethylammonium dichloroiodate(1-)

Kajigaeshi, Shoji; Kakinami, Takaaki; Yamasaki, Hiromichi; Fujisaki, Shizuo; Kondo, Manabu; et al, Chemistry Letters, 1987, (11), 2109-12

合成路线：1 步

_59%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Methanol , Water ; 10 - 20 °C; 1 h, 5 °C; 5 °C → 0 °C
1.2 Reagents: Potassium iodide Catalysts: Potassium periodate ; 0 - 15 °C; 30 min, 0 °C; 2 h, 10 °C; overnight, 20 °C
1.3 Reagents: Sodium pyrosulfite ; 20 °C; 30 min, rt

参考文献：

Development of an asymmetric hydrogenation route to (S)-N-Boc-2,6-dimethyltyrosine

Praquin, Celine F. B.; de Koning, Pieter D.; Peach, Philip J.; Howard, Roger M.; Spencer, Sarah L., Organic Process Research & Development, 2011, 15(5), 1124-1129

合成路线：1 步

_24%

反应条件：

1.1 Reagents: Hydrochloric acid , Potassium iodide , Potassium iodate Solvents: Methanol , Water ; 0 °C; overnight, 0 °C → rt

参考文献：

Novel Ligands Lacking a Positive Charge for the δ- and μ-****** Receptors

Schiller, Peter W.; Berezowska, Irena; Nguyen, Thi M.-D.; Schmidt, Ralf; Lemieux, Carole; et al, Journal of Medicinal Chemistry, 2000, 43(4), 551-559

合成路线：1 步

_65%

反应条件：

1.1 Reagents: Iodine , Oxygen Catalysts: Nitric acid Solvents: 1,2-Dichloroethane , Water ; 0.5 h, 0.1 MPa, 20 °C
1.2 Reagents: Sodium sulfite Solvents: Water

参考文献：

Metal-free catalytic aerobic oxyiodination of organic molecules activated by HNO3

Wang, Kaiyang; Wang, Xinliang; Liang, Xinmiao, Jingxi Huagong, 2009, 26(10), 1032-1035

合成路线：1 步

_53%

反应条件：

1.1 Reagents: tert-Butyl hydroperoxide , Potassium iodide Solvents: Methanol , Water ; 30 min, rt; 8 h, rt
1.2 Reagents: Sodium thiosulfate

参考文献：

Mild and efficient oxy-iodination of alkynes and phenols with potassium iodide and tert-butyl hydroperoxide

Rajender Reddy, K.; Venkateshwar, M.; Uma Maheswari, C.; Santhosh Kumar, P., Tetrahedron Letters, 2010, 51(16), 2170-2173

合成路线：1 步

_32%

反应条件：

1.1 Reagents: Sulfuric acid , Potassium iodide , Hydrogen peroxide Catalysts: Sodium dodecyl sulfate Solvents: Water ; 2 h, 303 °C
1.2 Reagents: Hexadecyltrimethylammonium bromide Solvents: Water

参考文献：

Selectivity enhancement of aromatic halogenation reactions at the micellar interface: effect of highly ionic media

Samant, Bhupesh S.; Bhagwat, Sunil S., Monatshefte fuer Chemie, 2012, 143(7), 1039-1044

合成路线：1 步