829-20-9 (2,4-二甲氧基苯乙酮,2&#x27;,4&#x27;-Dimethoxyacetophenone)

反应条件：

1.1 Reagents: Oxygen Catalysts: Montmorillonite ((Al1.33-1.67Mg0.33-0.67)(Ca0-1Na0-1)0.33Si4(OH)2O10.xH2O) ; rt; 12 h, rt

参考文献：

A facile deprotection of N,N-dimethylhydrazones using montmorillonite KSF as catalyst

Hosseinzadeh, Rahmam; et al, Chemistry: An Indian Journal, 2003, 1(1), 53-56

合成路线：1 步

108-24-7

_99%

反应条件：

1.1 Catalysts: 4′-(4-Hydroxyphenyl)-2,2′:6′,2′′-terpyridine (reaction products with poly{[(hydroxyphenyl)methylene]-methylphosphoro…) , Scandium triflate , Phosphorodichloridothioic hydrazide, 2-[(4-hydroxyphenyl)methylene]-1-methyl-, h… (terpyridinylphenyl-terminated) Solvents: Acetonitrile ; 15 min, rt
1.2 30 min, heated

参考文献：

Efficient and recyclable rare earth-based catalysts for Friedel-Crafts acylations under microwave heating: dendrimers show the way

Perrier, Arnaud; et al, Green Chemistry, 2013, 15(8), 2075-2080

合成路线：1 步

108-24-7

_94%

反应条件：

1.1 4 h, 393 K

参考文献：

Synthesis of industrially important aromatic and heterocyclic ketones using hierarchical ZSM-5 and Beta zeolites

Kore, Rajkumar; et al, Applied Catalysis, 2015, 493, 129-141

合成路线：1 步

75-36-5

_99%

反应条件：

1.1 Catalysts: Benzenesulfonic acid, 4-methyl-, indium(3+) salt (3:1) Solvents: Nitromethane ; 2 h, reflux

参考文献：

Catalysis of the acylation of aromatic derivatives by metallic tosylates

Morizur, Vincent; et al, Tetrahedron, 2015, 71(38), 6813-6817

合成路线：1 步

75-36-5

_91%

反应条件：

1.1 Catalysts: Benzenemethanaminium, N,N,N-triethyl-, μ-chlorodecachlorodiantimonate(1-) Solvents: Nitromethane ; 20 min, reflux

参考文献：

Friedel-Crafts acylation reactions using catalytic SbCl5-TEBA complex as an efficient catalyst

Huang, An Ping; et al, Chinese Chemical Letters, 2004, 15(12), 1415-1418

合成路线：1 步

86774-70-1

16872-11-0

_98%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; 10 min, pH 10, reflux

参考文献：

Reactions of nitrilium salts with indole and pyrrole and their derivatives in the synthesis of imines, ketones and secondary amines

Giles, Robert G.; et al, Tetrahedron, 2015, 71(39), 7367-7385

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; 12 h, 65 °C

参考文献：

Synthesis of 2',4'-dimethoxychalcone derivatives and evaluation of their antitumor activities against non-small cell lung cancer

Choi, Myeong A.; et al, Yakhak Hoechi, 2016, 60(3), 135-140

合成路线：1 步

_83%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone

参考文献：

Synthesis of acyclic and cyclic phosphonates based on substituted 2-hydroxybenzylic alcohols

Terekhova, N. V.; et al, Russian Chemical Bulletin, 2020, 69(11), 2147-2152

合成路线：1 步

829-19-6

_97%

反应条件：

1.1 Reagents: tert-Butyl hydroperoxide Catalysts: Eosin Solvents: Acetonitrile , Decane ; 24 h, 25 °C

参考文献：

Visible light mediated chemo-selective oxidation of benzylic alcohols

Devari, Shekaraiah; et al, Tetrahedron Letters, 2016, 57(30), 3294-3297

合成路线：1 步

829-19-6

_94%

反应条件：

1.1 Reagents: Acetone , Sodium tert-butoxide Catalysts: Stereoisomer of [1,8-bis[bis(1-methylethyl)phosphino-κP]-9,10[1′,2′]-benzenoanth… Solvents: Acetone ; 56 °C; 6 h, 56 °C

参考文献：

Cyclometalated phosphine-based Ir(III) pincer complex as a catalyst for Oppenauer-type oxidation of alcohols

Levy, Roy; et al, Catalysis Communications, 2009, 11(4), 298-301

合成路线：1 步

829-19-6

_93%

反应条件：

1.1 Reagents: Oxygen Catalysts: Palladium (solid-supported) Solvents: Toluene ; 5 h, 110 °C

参考文献：

Solid-supported Pd(0): an efficient heterogeneous catalyst for aerobic oxidation of benzyl alcohols into aldehydes and ketones

Bandna; et al, Tetrahedron Letters, 2011, 52(38), 4954-4956

合成路线：1 步

75-05-8

反应条件：

1.1 Reagents: Water Catalysts: Trifluoromethanesulfonic acid Solvents: Water

参考文献：

The chemistry of nitrilium salts. Part 1. Acylation of phenols and phenol ethers with nitriles and trifluoromethanesulfonic acid

Booth, Brian L.; et al, Journal of the Chemical Society, 1980, (12), 2894-900

合成路线：1 步

74-88-4

_94%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetone ; rt; 44 h, reflux

参考文献：

Peptoid Helix Displaying Flavone and Porphyrin: Synthesis and Intramolecular Energy Transfer

Yang, Woojin; et al, Journal of Organic Chemistry, 2020, 85(3), 1392-1400

合成路线：1 步

74-88-4

_92%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; 16 h, rt

参考文献：

Kolbe-Schmitt type reaction under ambient conditions mediated by an organic base

Sadamitsu, Yuta; et al, Chemical Communications (Cambridge, 2019, 55(66), 9837-9840

合成路线：1 步

18986-10-2

_93%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile

参考文献：

Facile transformation of N,N-dimethylhydrazones and tosylhydrazones to ketones with dimethyl sulfate and potassium carbonate

Kamal, Ahmed; et al, Synthetic Communications, 1998, 28(21), 3927-3931

合成路线：1 步

216001-43-3

_93%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile

参考文献：

Facile transformation of N,N-dimethylhydrazones and tosylhydrazones to ketones with dimethyl sulfate and potassium carbonate

Kamal, Ahmed; et al, Synthetic Communications, 1998, 28(21), 3927-3931

合成路线：1 步

917-54-4

91-52-1

_93%

反应条件：

1.1 Solvents: Tetrahydrofuran ; 0.5 - 2 h, -78 °C
1.2 Reagents: Water , Hydrogen ion

参考文献：

A new route for the synthesis of flavanones from 2-methoxybenzoic acids

Lee, Jae In; et al, Bulletin of the Korean Chemical Society, 2005, 26(12), 2044-2046

合成路线：1 步

917-54-4

91-52-1

_93%

反应条件：

1.1 Solvents: Diethyl ether , Tetrahydrofuran ; 1 h, -78 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

A novel synthesis of flavones from 2-methoxybenzoic acids

Lee, Jae In; et al, Bulletin of the Korean Chemical Society, 2005, 26(9), 1461-1463

合成路线：1 步

23997-80-0

_86%

反应条件：

1.1 Reagents: N,N-Dibromobenzenesulfonamide Solvents: Carbon tetrachloride ; 30 min, rt

参考文献：

N,N-dibromobenzenesulfonamide as a reagent for oxidative cleavage of oximes to their parent carbonyl compounds under non-aqueous and aprotic conditions

Tajbakhsh, Mahmood; et al, Journal of Chemical Research, 2004, (2), 141-142

合成路线：1 步

23997-80-0

_86%

反应条件：

1.1 Reagents: N,N-Dibromobenzenesulfonamide Solvents: Carbon tetrachloride ; 30 min, 20 - 25 °C

参考文献：

Deoximation with N-Bromosulfonamides

Tajbaksh, M.; et al, Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii), 2003, 39(7), 1053-1054

合成路线：1 步

150-78-7

75-36-5

_81%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; 4 h, rt

参考文献：

Synthesis of 2,5-dimethoxyethylbenzene

Chen, Guan-fan; et al, Hecheng Huaxue, 2003, 11(5), 443-444

合成路线：1 步

38447-66-4

_77%

反应条件：

1.1 Catalysts: 9,10-Dimethylanthracene Solvents: Acetonitrile ; 15 - 20 h

参考文献：

p-Selective (sp2)-C-H functionalization for an acylation/alkylation reaction using organic photoredox catalysis

Pandey, Ganesh; et al, Chemical Communications (Cambridge, 2017, 53(91), 12337-12340

合成路线：1 步

1124-53-4

_74%

反应条件：

1.1 Reagents: Trifluoromethanesulfonic anhydride , 2-Fluoropyridine Solvents: Dichloromethane ; -78 °C; 10 min, 0 °C
1.2 0 °C; 0 °C → 40 °C; 1 h, 40 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; rt → reflux; 2 h, reflux; reflux → rt

参考文献：

Metal-Free Intermolecular Coupling of Arenes with Secondary Amides: Chemoselective Synthesis of Aromatic Ketimines and Ketones, and N-Deacylation of Secondary Amides

Huang, Pei-Qiang; et al, Journal of Organic Chemistry, 2016, 81(19), 9020-9027

合成路线：1 步

_60%

反应条件：

1.1 Solvents: Dichloromethane ; 48 h, reflux
1.2 Reagents: Sodium hydroxide Solvents: Water ; pH 7, rt

参考文献：

Reactions of nitrilium salts with indole and pyrrole and their derivatives in the synthesis of imines, ketones and secondary amines

Giles, Robert G.; et al, Tetrahedron, 2015, 71(39), 7367-7385

合成路线：1 步

552-41-0

334-88-3

_49%

反应条件：

1.1 Solvents: Diethyl ether , Methanol

参考文献：

Action of diazomethane on hydroxy compounds and of diazomethane derivatives on phenanthraquinone

Schonberg, Alexander; et al, Journal of the Chemical Society, 1946, 746, 746-8

合成路线：1 步

_30%

参考文献：

The synthesis and some reactions of N-methylnitrilium trifluoromethanesulfonate salts

Booth, Brian L.; et al, Journal of the Chemical Society, 1980, (23), 1151-3

合成路线：2 步

反应条件：

1.1 -
2.1 Catalysts: Sodium bicarbonate

参考文献：

The chemistry of nitrilium salts. Part 3. The importance of triazinium salts in Houben-Hoesch reactions catalyzed by trifluoromethanesulfonic acid

Amer, Muhannad I.; et al, Journal of the Chemical Society, 1983, (5), 1075-81

合成路线：1 步

91-52-1

88-12-0

_23%

反应条件：

1.1 Reagents: Quinone Catalysts: Palladium trifluoroacetate , 6-Methyl-2,2′-bipyridine Solvents: Dimethylformamide ; 24 h, rt → 120 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 2 h, rt

参考文献：

Palladium(II)-Catalyzed Decarboxylative Heck Arylations of Acyclic Electron-Rich Olefins with Internal Selectivity

Fardost, Ashkan; et al, Advanced Synthesis & Catalysis, 2014, 356(4), 870-878

合成路线：1 步

1026990-71-5