83-25-0 (N-苯基丁二酰亚胺,1-Phenylpyrrolidine-2,5-dione)

反应条件：

1.1 Reagents: Acetic anhydride , Zinc Solvents: Toluene ; rt → 40 °C; 48 h, 86 °C

参考文献：

An Efficient One-Pot Synthesis of Bis Butenolides

Bayat, Mohammad; et al, Journal of Heterocyclic Chemistry, 2016, 53(5), 1661-1664

合成路线：1 步

941-69-5

_99%

反应条件：

1.1 Reagents: Phenylsilane , Water Catalysts: Phosphetane, 1,2,2,3,4,4-hexamethyl-, 1-oxide Solvents: Toluene ; 24 h, 80 °C

参考文献：

Reduction of Activated Alkenes by PIII/PV Redox Cycling Catalysis

Longwitz, Lars ; et al, Angewandte Chemie, 2020, 59(7), 2760-2763

合成路线：1 步

941-69-5

_96%

反应条件：

1.1 Reagents: Ammonium formate Catalysts: Palladium Solvents: Acetic acid

参考文献：

Catalytic transfer hydrogenation of unsaturated ketones and imides via ammonium formate

Pande, P. P.; et al, Synthetic Communications, 1998, 28(22), 4193-4200

合成路线：1 步

3262-89-3

_98%

反应条件：

1.1 Catalysts: Copper(II) triflate Solvents: Ethanol ; 6 h, 40 °C

参考文献：

N-arylation of amines, amides, amides and sulfonamides with arylboroxine catalyzed by simple copper salt/EtOH system

Zheng, Zhang-Guo; et al, Beilstein Journal of Organic Chemistry, 2008, 4,

合成路线：1 步

603-33-8

_98%

反应条件：

1.1 Reagents: Pyridine , Cupric acetate

参考文献：

Promotion of reaction of N-H bonds with triarylbismuth and cupric acetate

Chan, Dominic M. T., Tetrahedron Letters, 1996, 37(50), 9013-9016

合成路线：1 步

603-33-8

_20%

反应条件：

1.1 Reagents: Pyridine Catalysts: Cupric acetate Solvents: Dichloromethane ; 5 min, rt; 7 d, rt

参考文献：

Comparison of copper(II) acetate promoted N-arylation of 5,5-dimethylhydantoin and other imides with triarylbismuthanes and arylboronic acids

Hugel, Helmut M.; et al, Synlett, 2006, (14), 2290-2292

合成路线：1 步

603-33-8

参考文献：

Product class 2: Triacylamines, imides (diacylamines), and related compounds

Luzzio, F. A., Science of Synthesis, 2005, 21, 259-324

合成路线：1 步

108-31-6

_97%

反应条件：

1.1 30 min, 130 - 135 °C; 2 h, 135 °C → 150 °C
1.2 Reagents: Water ; cooled

参考文献：

A modified industrial procedure for large scale preparation of N-alkylimides and N-arylimides in improved yields

Adeppa, K.; et al, Proceedings of the National Academy of Sciences, 2010, 80(1), 30-36

合成路线：2 步

108-31-6

反应条件：

1.1 Solvents: Diethyl ether ; 1 h, rt
1.2 Reagents: Acetic anhydride Catalysts: Sodium acetate Solvents: Acetic anhydride ; 30 min, heated
2.1 Reagents: Triethylsilane Catalysts: Grubbs second generation catalyst Solvents: Dichloromethane ; 30 min, 150 °C

参考文献：

The non-metathetic role of Grubbs' carbene complexes: from hydrogen-free reduction of α,β-unsaturated alkenes to solid-supported sequential cross-metathesis/reduction

Poeylaut-Palena, Andres A.; et al, Chemical Communications (Cambridge, 2011, 47(5), 1565-1567

合成路线：2 步

108-31-6

反应条件：

1.1 Solvents: Polyethylene glycol ; 190 min, 60 °C
2.1 Reagents: Magnesium Solvents: Ethanol ; 2 - 5 h, reflux

参考文献：

PEG-600 mediated simple, efficient and eco-friendly synthesis of N-substituted imides and chemo selective C=C reduction

Kumar, Padam Praveen; et al, Green Chemistry Letters and Reviews, 2011, 4(4), 341-348

合成路线：1 步

_96%

反应条件：

1.1 Solvents: 1-Butyl-3-methylimidazolium hexafluorophosphate ; 20 min, 140 °C

参考文献：

Organic reactions in ionic liquids: Ionic liquid-promoted efficient synthesis of N-alkyl and N-arylimides

Le, Zhang-Gao; et al, Synthesis, 2004, (7), 995-998

合成路线：1 步

_95%

反应条件：

1.1 Solvents: Polyethylene glycol ; 3 h, 120 °C

参考文献：

Polyethylene Glycol as a Nonionic Liquid Solvent for the Synthesis of N-Alkyl and N-Arylimides

Liang, Jun; et al, Synthetic Communications, 2009, 39(16), 2822-2828

合成路线：1 步

98-80-6

_96%

反应条件：

1.1 Catalysts: Copper , Graphene Solvents: Methanol ; 17 h, 40 °C

参考文献：

Enhanced catalytic performance by copper nanoparticle-graphene based composite

Mondal, Paramita; et al, RSC Advances, 2013, 3(16), 5615-5623

合成路线：1 步

98-80-6

_96%

反应条件：

1.1 Reagents: Oxygen Catalysts: Cupric acetate Solvents: Methanol ; 10 - 180 min, reflux

参考文献：

A simple copper salt catalyzed N-arylation of amines, amides, imides, and sulfonamides with arylboronic acids

Lan, Jing-Bo; et al, Synlett, 2004, (6), 1095-1097

合成路线：1 步

98-80-6

_93%

反应条件：

1.1 Reagents: Pyridine Catalysts: Cupric acetate Solvents: Dichloromethane ; 5 min, rt; 7 d, rt

参考文献：

Comparison of copper(II) acetate promoted N-arylation of 5,5-dimethylhydantoin and other imides with triarylbismuthanes and arylboronic acids

Hugel, Helmut M.; et al, Synlett, 2006, (14), 2290-2292

合成路线：1 步

91012-01-0

_96%

反应条件：

1.1 Reagents: Sodium hydroxide , Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water ; 1 h, rt
1.2 Reagents: Sodium bisulfite Solvents: Water ; rt

参考文献：

Metal-Free Synthesis of N-Aryl Amides using Organocatalytic Ring-Opening Aminolysis of Lactones

Guo, Wusheng; et al, ChemSusChem, 2017, 10(9), 1969-1975

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Sodium acetate Solvents: Acetic anhydride

参考文献：

A simple key for benzylic mono- and gem-dibromination of primary aromatic amine derivatives using molecular bromine

Kar, Anirban; et al, Synthesis, 2002, (2), 221-224

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Thionyl chloride Solvents: Benzene ; 30 min, reflux
1.2 reflux

参考文献：

Synthesis, characterization & antimicrobial screening of 1-(substituted phenyl)-2,5-bis(ethylsulfanyl)-1H-pyrrole-3,4-dicarbaldehydes

Rajput, A. P.; et al, Pharma Chemica, 2015, 7(8), 143-148

合成路线：1 步

_94%

反应条件：

1.1 Solvents: Water ; 12 h, 80 °C; cooled
1.2 Solvents: Water ; rt

参考文献：

A convenient one-pot synthesis of polysubstituted pyrroles from N-protected succinimides

Kobeissi, Marwan; et al, Tetrahedron Letters, 2014, 55(15), 2523-2526

合成路线：1 步

_90%

反应条件：

1.1 Catalysts: Niobium oxide (Nb2O3) Solvents: Hexane ; rt → reflux; 10 h, reflux

参考文献：

Versatile and Sustainable Synthesis of Cyclic Imides from Dicarboxylic Acids and Amines by Nb2O5 as a Base-Tolerant Heterogeneous Lewis Acid Catalyst

Ali, Ayub Md.; et al, Chemistry - A European Journal, 2014, 20(44), 14256-14260

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Sodium acetate Solvents: Acetic anhydride
1.2 Solvents: Dichloromethane

参考文献：

The synthesis and reactions of some N-acyl-N-aryliminium ions

Brunton, Shirley; et al, ARKIVOC [online computer file], 2000, 1(3), 292-303

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Thionyl chloride Solvents: Ethanol ; 2 h, 60 °C

参考文献：

Synthesis of cyclic imides from amic acids using thionyl chloride

Guenadil, Faouzi, Journal Marocain de Chimie Heterocyclique, 2020, 19(4), 48-50

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Triethylamine Solvents: Acetonitrile
1.2 Reagents: 1H-Benzotriazole-1-carboxylic acid, ethyl ester, 3-oxide

参考文献：

Synthesis of the succinimides by the 3-(ethoxycarbonyl)benzotriazole-1-oxide

Topuzyan, V. O.; et al, Hayastani Kimiakan Handes, 2002, 55(3), 90-94

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Potassium carbonate , Oxygen Catalysts: Copper chloride Solvents: Dimethyl sulfoxide ; 1 h, 25 °C; 12 h, 25 °C

参考文献：

Efficient copper-catalyzed N-arylation of NH-containing heterocycles and sulfonamides with arenediazonium tetrafluoroborates

Ouyang, Yu-Qing; et al, Synthetic Communications, 2017, 47(8), 771-778

合成路线：1 步

168333-60-6

_92%

反应条件：

1.1 Solvents: Dichloromethane
1.2 Reagents: Acetic acid , Tetrabutylammonium fluoride Solvents: Methanol , Tetrahydrofuran
1.3 Reagents: Potassium cyanide Solvents: Methanol , Dimethylformamide

参考文献：

Ketenes in Soluble Polymer Bound Synthesis: Preparation of Succinamides and 4-Pyridones

Far, Adel Rafai; et al, Journal of Organic Chemistry, 1998, 63(24), 8636-8637

合成路线：1 步

71-43-2

_88%

反应条件：

1.1 Reagents: Iodobenzene diacetate Solvents: Benzene ; 4 h, 140 °C

参考文献：

Intermolecular Oxidative C-N Bond Formation under Metal-Free Conditions: Control of Chemoselectivity between Aryl sp2 and Benzylic sp3 C-H Bond Imidation

Kim, Hyun Jin; et al, Journal of the American Chemical Society, 2011, 133(41), 16382-16385

合成路线：1 步

71-43-2

_83%

反应条件：

1.1 Reagents: Iodobenzene diacetate Solvents: Benzene ; 3 h, 145 °C

参考文献：

Metal-Free Intermolecular Oxidative C-N Bond Formation via Tandem C-H and N-H Bond Functionalization

Kantak, Abhishek A.; et al, Journal of the American Chemical Society, 2011, 133(49), 19960-19965

合成路线：1 步

591-50-4

_87%

反应条件：

1.1 Reagents: Copper Solvents: Water ; 6 min

参考文献：

Active-copper-promoted expeditious N-arylations in aqueous media under microwave irradiation

Yadav, Lal Dhar S.; et al, Synthesis, 2006, (11), 1868-1872

合成路线：1 步

591-50-4

_64%

反应条件：

1.1 Reagents: Copper sulfate

参考文献：

Copper promoted coupling reaction. I. Phenylation of oxygen-hydrogen and nitrogen-hydrogen compounds with C6H5X by using copper catalyst itself as the acceptor of HX released

Yamamoto, Takakazu, Synthetic Communications, 1979, 9(3), 219-22

合成路线：1 步

102-07-8

_85%

参考文献：

A new method for the preparation of carboxylic anilides and N-substituted succinimides

Rahman, Azizur; et al, Chemische Berichte, 1953, 86, 945-7

合成路线：1 步

128-08-5

71-43-2

_83%

反应条件：

1.1 Catalysts: Gold trichloride Solvents: 1,2-Dichloroethane ; 11 h, 80 °C
1.2 Reagents: Copper Solvents: Dimethylformamide ; 0.5 h, 150 °C

参考文献：

Gold-catalyzed halogenation of aromatics by N-halosuccinimides

Mo, Fanyang; et al, Angewandte Chemie, 2010, 49(11), 2028-2032

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cupric nitrate Solvents: Toluene ; 24 h, 70 °C

参考文献：

Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts

Neerbye Berntsen, Linn; et al, Organic Letters, 2020, 22(7), 2687-2691

合成路线：1 步

582-61-6

_80%

参考文献：

Acid azides: Part VII. Synthesis of N-arylimides from acid azides

Fahmy, A. F. M.; et al, Indian Journal of Chemistry, 1979, (4), 399-400

合成路线：1 步

36342-11-7

_78%

反应条件：

1.1 Catalysts: Zinc Solvents: Acetic acid ; 1 h, reflux; rt

参考文献：

α-Chlorosuccinimides, a new source for maleimides and succinimides

Gaina, Constantin; et al, Revue Roumaine de Chimie, 2005, 50(7-8), 655-661

合成路线：1 步

64-10-8

_77%