83603-31-0 (5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-,5,8,11,13-Eicosatetraenoicacid, 15-hydroxy-, (5Z,8Z,11Z,13E,15R)-)

快速询单

结构式：

5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-MOL文件

CAS号：

83603-31-0

中文名称：

5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-

英文名称：

5,8,11,13-Eicosatetraenoicacid, 15-hydroxy-, (5Z,8Z,11Z,13E,15R)-

分子式：

C₂₀H₃₂O₃

分子量：

320.466286659241

5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-(83603-31-0)名称与标识符

名称

英文别名：

5,8,11,13-Eicosatetraenoicacid, 15-hydroxy-, (5Z,8Z,11Z,13E,15R)-;15(R)-HEDE;15(R)-HETE;(5Z,8Z,11Z,13E,15R)-15-Hydroxy-5,8,11,13-eicosatetraenoic acid (ACI);5,8,11,13-Eicosatetraenoic acid, 15-hydroxy-, [R-(E,Z,Z,Z)]- (ZCI);15(R)-Hydroxyeicosatetraenoic acid;D-(R)-15-Hydroxy-5,8,11,13-eicosatetraenoic acid;KBio2_005193;KBio3_000113;DTXSID50390600;Bio1_000540;KBio2_002625;83603-31-0;15(s)-hydroxy-5,8,11,13-eicosatetraenoic acid;NS00122646;(15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid;KBio2_000057;KBio3_000114;CBiol_001765;Bio1_000051;Bio2_000057;KBioSS_000057;KBioGR_000057;Bio2_000537;Bio1_001029;CTK3E6555;

标识符

InChIKey：

JSFATNQSLKRBCI-UDQWCNDOSA-N

Inchi：

1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m1/s1

SMILES：

C(/[C@H](O)CCCCC)=C\C=C/C/C=C\C/C=C\CCCC(=O)O

5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-(83603-31-0)物化性质

实验特性

LogP : 5.18750
PSA : 57.53000

计算特性

精确分子量 : 320.23514488g/mol
氢键供体数量 : 2
氢键受体数量 : 3
可旋转化学键数量 : 14
同位素质量 : 320.23514488g/mol
重原子数量 : 23
复杂度 : 392
同位素原子数量 : 0
确定原子立构中心数量 : 1
不确定原子立构中心数量 : 0
确定化学键立构中心数量 : 4
不确定化学键立构中心数量 : 0
共价键单元数量 : 1
疏水参数计算参考值（XlogP） : 5.1
拓扑分子极性表面积 : 57.5Å²

5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-(83603-31-0)推荐厂家更多厂家(7)

公司名称	手机号/电话	联系人	QQ	询单
上海源叶生物科技有限公司	15026964105 15026964105	汤思磊	2881489226	询单
江苏永健医药科技有限公司	17701422016	韩经理	3587493084	询单
上海瀚思化工有限公司	18939883912 021-34536277	顾经理	3003949364	询单
上海甄准生物科技有限公司	13816009161 021-68920155	姜经理13816009161	3001086693	询单
上海甄准生物科技有限公司	13816009161 021-68920155	姜经理13816009161	3001086693	询单
上海赛可锐生物科技有限公司	13003271654 021-58000709	赛可锐生物	3004122151	询单
上海吉至生化科技有限公司	18117592386 021-57481218	吉至试剂	3007522982	询单

5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-(83603-31-0)合成路线

合成路线：1 步

102282-63-3

83603-31-0

反应条件：

1.1 Reagents: Pyridine, hydrofluoride (1:1) Solvents: Tetrahydrofuran
1.2 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water

参考文献：

Stereocontrolled total synthesis of (5Z,8Z,11Z,13E)(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15S-HETE) and analogs

Nicolaou, K. C.; et al, Journal of the Chemical Society, 1985, (22), 1580-1

合成路线：2 步

102228-20-6

83603-31-0

反应条件：

1.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
2.1 Reagents: Pyridine, hydrofluoride (1:1) Solvents: Tetrahydrofuran
2.2 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water

参考文献：

Stereocontrolled total synthesis of (5Z,8Z,11Z,13E)(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15S-HETE) and analogs

Nicolaou, K. C.; et al, Journal of the Chemical Society, 1985, (22), 1580-1

合成路线：3 步

102228-24-0

102228-22-8

83603-31-0

反应条件：

1.1 Reagents: Propylamine Catalysts: Cuprous iodide , Tetrakis(triphenylphosphine)palladium Solvents: Benzene
2.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
3.1 Reagents: Pyridine, hydrofluoride (1:1) Solvents: Tetrahydrofuran
3.2 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water

参考文献：

Stereocontrolled total synthesis of (5Z,8Z,11Z,13E)(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15S-HETE) and analogs

Nicolaou, K. C.; et al, Journal of the Chemical Society, 1985, (22), 1580-1

合成路线：4 步

102228-21-7

83603-31-0

反应条件：

1.1 Reagents: Potassium fluoride (KF), dihydrate Solvents: Dimethylformamide
2.1 Reagents: Propylamine Catalysts: Cuprous iodide , Tetrakis(triphenylphosphine)palladium Solvents: Benzene
3.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
4.1 Reagents: Pyridine, hydrofluoride (1:1) Solvents: Tetrahydrofuran
4.2 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water

参考文献：

Stereocontrolled total synthesis of (5Z,8Z,11Z,13E)(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15S-HETE) and analogs

Nicolaou, K. C.; et al, Journal of the Chemical Society, 1985, (22), 1580-1

合成路线：5 步

102279-39-0

83603-31-0

反应条件：

1.1 Reagents: Chromic acid (H2CrO4) Solvents: Acetone
1.2 Reagents: Diazomethane Solvents: Diethyl ether
2.1 Reagents: Potassium fluoride (KF), dihydrate Solvents: Dimethylformamide
3.1 Reagents: Propylamine Catalysts: Cuprous iodide , Tetrakis(triphenylphosphine)palladium Solvents: Benzene
4.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
5.1 Reagents: Pyridine, hydrofluoride (1:1) Solvents: Tetrahydrofuran
5.2 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water

参考文献：

Stereocontrolled total synthesis of (5Z,8Z,11Z,13E)(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15S-HETE) and analogs

Nicolaou, K. C.; et al, Journal of the Chemical Society, 1985, (22), 1580-1

合成路线：6 步

102228-19-3

83603-31-0

反应条件：

1.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
2.1 Reagents: Chromic acid (H2CrO4) Solvents: Acetone
2.2 Reagents: Diazomethane Solvents: Diethyl ether
3.1 Reagents: Potassium fluoride (KF), dihydrate Solvents: Dimethylformamide
4.1 Reagents: Propylamine Catalysts: Cuprous iodide , Tetrakis(triphenylphosphine)palladium Solvents: Benzene
5.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
6.1 Reagents: Pyridine, hydrofluoride (1:1) Solvents: Tetrahydrofuran
6.2 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water

参考文献：

Stereocontrolled total synthesis of (5Z,8Z,11Z,13E)(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15S-HETE) and analogs

Nicolaou, K. C.; et al, Journal of the Chemical Society, 1985, (22), 1580-1

合成路线：7 步

102228-18-2

1066-54-2

83603-31-0

反应条件：

1.1 Reagents: Ethylmagnesium bromide Solvents: Tetrahydrofuran
1.2 Reagents: Copper bromide (CuBr)
2.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
3.1 Reagents: Chromic acid (H2CrO4) Solvents: Acetone
3.2 Reagents: Diazomethane Solvents: Diethyl ether
4.1 Reagents: Potassium fluoride (KF), dihydrate Solvents: Dimethylformamide
5.1 Reagents: Propylamine Catalysts: Cuprous iodide , Tetrakis(triphenylphosphine)palladium Solvents: Benzene
6.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
7.1 Reagents: Pyridine, hydrofluoride (1:1) Solvents: Tetrahydrofuran
7.2 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water

参考文献：

Stereocontrolled total synthesis of (5Z,8Z,11Z,13E)(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15S-HETE) and analogs

Nicolaou, K. C.; et al, Journal of the Chemical Society, 1985, (22), 1580-1

合成路线：8 步

102228-17-1

83603-31-0

反应条件：

1.1 Reagents: Sodium iodide Solvents: Acetone
2.1 Reagents: Ethylmagnesium bromide Solvents: Tetrahydrofuran
2.2 Reagents: Copper bromide (CuBr)
3.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
4.1 Reagents: Chromic acid (H2CrO4) Solvents: Acetone
4.2 Reagents: Diazomethane Solvents: Diethyl ether
5.1 Reagents: Potassium fluoride (KF), dihydrate Solvents: Dimethylformamide
6.1 Reagents: Propylamine Catalysts: Cuprous iodide , Tetrakis(triphenylphosphine)palladium Solvents: Benzene
7.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
8.1 Reagents: Pyridine, hydrofluoride (1:1) Solvents: Tetrahydrofuran
8.2 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water

参考文献：

Stereocontrolled total synthesis of (5Z,8Z,11Z,13E)(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15S-HETE) and analogs

Nicolaou, K. C.; et al, Journal of the Chemical Society, 1985, (22), 1580-1

合成路线：9 步

73448-13-2

1476-11-5

83603-31-0

反应条件：

1.1 Reagents: Ethylmagnesium bromide Solvents: Tetrahydrofuran
1.2 Reagents: Copper bromide (CuBr)
1.3 -
2.1 Reagents: Sodium iodide Solvents: Acetone
3.1 Reagents: Ethylmagnesium bromide Solvents: Tetrahydrofuran
3.2 Reagents: Copper bromide (CuBr)
4.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
5.1 Reagents: Chromic acid (H2CrO4) Solvents: Acetone
5.2 Reagents: Diazomethane Solvents: Diethyl ether
6.1 Reagents: Potassium fluoride (KF), dihydrate Solvents: Dimethylformamide
7.1 Reagents: Propylamine Catalysts: Cuprous iodide , Tetrakis(triphenylphosphine)palladium Solvents: Benzene
8.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
9.1 Reagents: Pyridine, hydrofluoride (1:1) Solvents: Tetrahydrofuran
9.2 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water

参考文献：

Stereocontrolled total synthesis of (5Z,8Z,11Z,13E)(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15S-HETE) and analogs

Nicolaou, K. C.; et al, Journal of the Chemical Society, 1985, (22), 1580-1

合成路线：10 步

18162-48-6

928-90-5

83603-31-0

反应条件：

1.1 Reagents: Imidazole Solvents: Dimethylformamide
2.1 Reagents: Ethylmagnesium bromide Solvents: Tetrahydrofuran
2.2 Reagents: Copper bromide (CuBr)
2.3 -
3.1 Reagents: Sodium iodide Solvents: Acetone
4.1 Reagents: Ethylmagnesium bromide Solvents: Tetrahydrofuran
4.2 Reagents: Copper bromide (CuBr)
5.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
6.1 Reagents: Chromic acid (H2CrO4) Solvents: Acetone
6.2 Reagents: Diazomethane Solvents: Diethyl ether
7.1 Reagents: Potassium fluoride (KF), dihydrate Solvents: Dimethylformamide
8.1 Reagents: Propylamine Catalysts: Cuprous iodide , Tetrakis(triphenylphosphine)palladium Solvents: Benzene
9.1 Reagents: Hydrogen Solvents: Quinoline , Hexane
10.1 Reagents: Pyridine, hydrofluoride (1:1) Solvents: Tetrahydrofuran
10.2 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water

参考文献：

Stereocontrolled total synthesis of (5Z,8Z,11Z,13E)(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15S-HETE) and analogs

Nicolaou, K. C.; et al, Journal of the Chemical Society, 1985, (22), 1580-1

合成路线：1 步

反应条件：

1.1 Reagents: NADPH , Ethylenediaminetetraacetic acid , EGTA , Phenylmethylsulfonyl fluoride , Dithiothreitol , Oxygen Catalysts: Monooxygenase Solvents: Water ; 30 - 40 min, pH 7.4, 37 °C

参考文献：

bis-Allylic hydroxylation of polyunsaturated fatty acids by hepatic monooxygenases and its relation to the enzymic and nonenzymic formation of conjugated hydroxy fatty acids

Oliw, Ernst H.; et al, Archives of Biochemistry and Biophysics, 1993, 300(1), 434-9

合成路线：1 步

_52%

反应条件：

1.1 Reagents: Oxygen Catalysts: Arachidonate lipoxygenase Solvents: Water ; 0 - 3 °C; 25 min, 35 psi, < 5 °C
1.2 Reagents: Sodium borohydride ; 60 - 90 min, 0 - 5 °C
1.3 Reagents: Sulfuric acid Solvents: Water ; pH 3

参考文献：

Manufacture of (5Z,8Z,11Z,13E)(15S)-15-Hydroxyeicosa-5,8,11,13-tetraenoic Acid Sodium Salt for Clinical Trials

Conrow, Raymond E.; et al, Organic Process Research & Development, 2011, 15(1), 301-304

155976-53-7(4,7,10,13,15,19-二十二碳六烯酸，17-羟基-（4Z，7Z，10Z，13Z，15E，17R，19Z）-) 10075-11-3(10,12-十八碳二烯酸，9-羟基-（9R，10E，12Z）-) 105500-09-2(（R，5Z，9E，11Z，14Z）-8-羟基-5,9,11,14-四烯酸) 109430-11-7(5,8,12,14,17-二十碳五烯酸，11-羟基-（5Z，8Z，11R，12E，14Z，17Z）-) 81246-81-3(5'-O-[二(4-甲氧基苯基)苯基甲基]-3'-O-[(叔丁基)二甲基硅烷基]尿苷) 80791-88-4(3'-甲氧基-2-氨基腺苷) 80808-96-4(1,5-二甲基-3,7-二氮杂双环3.3.1壬-9-酮) 80912-60-3(4-(1,3-苯并二氧代l-5-基)-1-环己酮)

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83603-31-0 (5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-,5,8,11,13-Eicosatetraenoicacid, 15-hydroxy-, (5Z,8Z,11Z,13E,15R)-)

5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-(83603-31-0)名称与标识符

名称

标识符

5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-(83603-31-0)物化性质

实验特性

计算特性

5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-(83603-31-0)推荐厂家 更多厂家(7)

5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-(83603-31-0)合成路线

目录

5,8,11,13-二十碳四烯酸，15-羟基-（5Z，8Z，11Z，13E，15R）-(83603-31-0)推荐厂家更多厂家(7)