84228-93-3 (反-3-(4-吡啶基)烯丙酸,4-Pyridineacrylic Acid)

_95%

反应条件：

1.1 Reagents: Pyridine Catalysts: Piperidine ; 67 °C

参考文献：

Synthesis and Hypoglycemic Activity of Aryl(Hetaryl)Propenoic Cyanopyrrolidine Amides

Kuranov, S. O.; Blokhin, M. E.; Borisov, S. A.; Khvostov, M. V.; Luzina, O. A.; et al, Russian Journal of Bioorganic Chemistry, 2019, 45(5), 374-380

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Pyridine Catalysts: Piperidine , Hydroquinone ; 50 °C; 1 h, 50 °C; 5 h, 50 °C → reflux

参考文献：

Structural features of pyridylcinnamic acid dimers and their extended hydrogen-bonded aggregations

Csanko, K.; Ruusuvuori, K. I.; Tolnai, B.; Sipos, P.; Berkesi, O.; et al, Journal of Molecular Structure, 2015, 1090, 25-33

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Aniline Solvents: Pyridine ; 8 - 10 h, reflux; reflux → rt
1.2 Reagents: Potassium carbonate Solvents: Water ; rt; reflux; reflux → rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents

Wu, Meng; Wang, Ziwen; Meng, Chuisong; Wang, Kailiang; Hu, Yanna; et al, PLoS One, 2013, 8(2),

合成路线：1 步

_86%

反应条件：

1.1 Solvents: Pyridine , Piperidine
1.2 Solvents: Diethyl ether

参考文献：

An advantageous synthesis of 2-substituted benzimidazoles using polyphosphoric acid. 2-(Pyridyl)-1H-benzimidazoles, 1-alkyl-(1H-benzimidazol-2-yl)pyridinium salts, their homologs and vinylogs.

Alcalde, Ermitas; Dinares, Immaculada; Perez-Garcia, Lluisa; Roca, Tomas, Synthesis, 1992, (4), 395-8

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Piperidine Solvents: Pyridine ; 0.5 h, rt → 100 °C

参考文献：

Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases

Vassiliou, Stamatia; Weglarz-Tomczak, Ewelina; Berlicki, Lukasz; Pawelczak, Malgorzata; Nocek, Boguslaw; et al, Journal of Medicinal Chemistry, 2014, 57(19), 8140-8151

合成路线：1 步

81124-49-4

_78%

反应条件：

1.1 Reagents: Lithium hydroxide Solvents: Methanol , Tetrahydrofuran , Water ; 24 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Development of tryptase inhibitors derived from thalidomide

Tetsuhashi, Masashi; Ishikawa, Minoru; Hashimoto, Mariko; Hashimoto, Yuichi; Aoyama, Hiroshi, Bioorganic & Medicinal Chemistry, 2010, 18(14), 5323-5338

合成路线：1 步

_76%

反应条件：

1.1 Catalysts: Piperidine Solvents: Pyridine ; 2 h, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid-base interactions

Kudelko, Agnieszka; Jasiak, Karolina; Ejsmont, Krzysztof, Monatshefte fuer Chemie, 2015, 146(2), 303-311

合成路线：1 步

_60%

反应条件：

1.1 Catalysts: Piperidine Solvents: Pyridine ; rt → 110 °C; 10 - 12 h, 110 °C; 110 °C → rt
1.2 Reagents: Sodium hydroxide Solvents: Water ; rt
1.3 Reagents: Sulfuric acid Solvents: Water ; pH 2

参考文献：

Design, synthesis and biological evaluation of (E)-5-styryl-1,2,4-oxadiazoles as anti-tubercular agents

Atmaram Upare, Abhay; Gadekar, Pradip K.; Sivaramakrishnan, H.; Naik, Nishigandha; Khedkar, Vijay M.; et al, Bioorganic Chemistry, 2019, 86, 507-512

合成路线：1 步

24489-96-1

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Methanol , Tetrahydrofuran , Water ; 0.5 - 2 h, rt

参考文献：

Synthesis, in vitro cytotoxicity, and molecular docking study of novel 3,4-dihydroisoquinolin-1(2H)-one based piperlongumine analogues

Kulkarni, Mahesh R. ; Lad, Nitin P.; Khedkar, Vijay M.; Gaikwad, Nitin D., Journal of Heterocyclic Chemistry, 2021, 58(6), 1359-1370

合成路线：1 步

反应条件：

1.1 Catalysts: Piperidine Solvents: Pyridine ; 4 h, 90 °C

参考文献：

[2+2] Photodimerization of Stilbazoles Promoted by Oxalic Acid in Suspension

Nguyen, Thanh Binh; Nguyen, Tuan Minh; Retailleau, Pascal, Chemistry - A European Journal, 2020, 26(21), 4682-4689

合成路线：1 步

123293-78-7

反应条件：

1.1 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water ; rt; 16 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 4 - 5, rt

参考文献：

Synthesis and evaluation of N-heteroaromatic ring-based analogs of piperlongumine as potent anticancer agents

Zou, Yu; Yan, Chang; Zhang, Huibin; Xu, Jinyi; Zhang, Dayong; et al, European Journal of Medicinal Chemistry, 2017, 138, 313-319

合成路线：1 步

参考文献：

Functionalization and Isoreticulation in a Series of Metal-Organic Frameworks Derived from Pyridinecarboxylates

Pachfule, Pradip; Garai, Bikash; Banerjee, Rahul, Inorganic Chemistry, 2016, 55(15), 7200-7205

合成路线：1 步

100-21-0

反应条件：

1.1 Reagents: Perchloric acid, iron(3+) salt, hydrate Solvents: Dimethylacetamide ; 5 d, 100 °C

参考文献：

Framework Cationization by Preemptive Coordination of Open Metal Sites for Anion-Exchange Encapsulation of Nucleotides and Coenzymes

Zhao, Xiang; Mao, Chengyu; Luong, Karen Tu; Lin, Qipu; Zhai, Quan-Guo; et al, Angewandte Chemie, 2016, 55(8), 2768-2772

合成路线：1 步

37535-49-2

反应条件：

1.1 Catalysts: Phenylalanine ammonia-lyase Solvents: Water ; pH 8.3, 30 °C

参考文献：

Bacterial Anabaena variabilis phenylalanine ammonia lyase: A biocatalyst with broad substrate specificity

Lovelock, Sarah L.; Turner, Nicholas J., Bioorganic & Medicinal Chemistry, 2014, 22(20), 5555-5557

合成路线：1 步

462633-44-9