84359-61-5 (9-(3-溴丙基)-9H-咔唑,9-(3-Bromopropyl)-9H-carbazole)

反应条件：

1.1 Reagents: Acetic acid Solvents: Tetrahydrofuran , Water ; 3 h, rt → 80 °C; cooled
1.2 Reagents: Ammonium hydroxide ; basified
1.3 Reagents: Carbon tetrabromide , Triphenylphosphine Solvents: Acetonitrile ; 2 h, rt
1.4 Reagents: Sodium hydroxide Solvents: Water ; basified

参考文献：

Structure-Activity Relationships at the Monoamine Transporters and σ Receptors for a Novel Series of 9-[3-(cis-3,5-Dimethyl-1-piperazinyl)- propyl]carbazole (Rimcazole) Analogues

Husbands, Stephen M.; et al, Journal of Medicinal Chemistry, 1999, 42(21), 4446-4455

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Benzyltriethylammonium chloride Solvents: Benzene , Water ; rt

参考文献：

Azocarbazole Polymethacrylates as Single-Component Electrooptic Materials

Barrett, Christopher; et al, Macromolecules, 1998, 31(15), 4845-4851

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Acetone ; 45 min
1.2 12 h, 70 °C

参考文献：

Hot-exciton harvesting via through-space single-molecule based white-light emission and optical waveguides

Barman, Debasish; et al, Chemical Science, 2022, 13(31), 9004-9015

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 0 °C; 15 h, rt
1.2 Solvents: Water ; cooled

参考文献：

New classes of carbazoles as potential multi-functional anti-Alzheimer's agents

Choubdar, Niloufar; et al, Bioorganic Chemistry, 2019, 91,

合成路线：1 步

106-94-5

_42%

反应条件：

1.1 Reagents: Sodium hydroxide , Tetrabutylammonium bromide Solvents: Benzene , Water ; overnight, rt

参考文献：

Photolytic Release of Carboxylic Acids Using Linked Donor-Acceptor Molecules: Direct versus Mediated Photoinduced Electron Transfer to N-Alkyl-4-picolinium Esters

Sundararajan, Chitra; et al, Organic Letters, 2005, 7(13), 2631-2634

合成路线：2 步

33821-94-2

反应条件：

1.1 Reagents: Sodium hydride , 15-Crown-5 Solvents: Toluene ; 20 min, rt
1.2 4 d, rt → reflux; reflux → rt
1.3 Reagents: Water
2.1 Reagents: Acetic acid Solvents: Tetrahydrofuran , Water ; 3 h, rt → 80 °C; cooled
2.2 Reagents: Ammonium hydroxide ; basified
2.3 Reagents: Carbon tetrabromide , Triphenylphosphine Solvents: Acetonitrile ; 2 h, rt
2.4 Reagents: Sodium hydroxide Solvents: Water ; basified

参考文献：

Structure-Activity Relationships at the Monoamine Transporters and σ Receptors for a Novel Series of 9-[3-(cis-3,5-Dimethyl-1-piperazinyl)- propyl]carbazole (Rimcazole) Analogues

Husbands, Stephen M.; et al, Journal of Medicinal Chemistry, 1999, 42(21), 4446-4455

合成路线：3 步

627-18-9

110-87-2

反应条件：

1.1 Catalysts: p-Toluenesulfonic acid Solvents: Chloroform ; 2 h, rt
2.1 Reagents: Sodium hydride , 15-Crown-5 Solvents: Toluene ; 20 min, rt
2.2 4 d, rt → reflux; reflux → rt
2.3 Reagents: Water
3.1 Reagents: Acetic acid Solvents: Tetrahydrofuran , Water ; 3 h, rt → 80 °C; cooled
3.2 Reagents: Ammonium hydroxide ; basified
3.3 Reagents: Carbon tetrabromide , Triphenylphosphine Solvents: Acetonitrile ; 2 h, rt
3.4 Reagents: Sodium hydroxide Solvents: Water ; basified

参考文献：

Structure-Activity Relationships at the Monoamine Transporters and σ Receptors for a Novel Series of 9-[3-(cis-3,5-Dimethyl-1-piperazinyl)- propyl]carbazole (Rimcazole) Analogues

Husbands, Stephen M.; et al, Journal of Medicinal Chemistry, 1999, 42(21), 4446-4455

合成路线：1 步

_55%