84661-56-3 (二(1H-咪唑-1-基)甲烷,Di(1H-imidazol-1-yl)methane)

_100%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Tetrabutylammonium bromide

参考文献：

Phase transfer catalysis without solvent. Synthesis of bisazolylalkanes

Diez-Barra, Enrique; De la Hoz, Antonio; Sanchez-Migallon, Ana; Tejeda, Juan, Heterocycles, 1992, 34(7), 1365-73

合成路线：1 步

_96%

参考文献：

N-Polyazolylmethanes. III. Synthesis and proton NMR study of 1,1'-methylenediimidazole and 1,1'-methylenedibenzimidazole derivatives

Claramunt, Rosa Maria; Elguero, Jose; Meco, Teresa, Journal of Heterocyclic Chemistry, 1983, 20(5), 1245-9

合成路线：1 步

50-00-0

_92%

反应条件：

1.1 Solvents: Tetrahydrofuran ; 6 min, 120 °C

参考文献：

Antibacterial activity of aminals and hemiaminals of pyrazole and imidazole

Lupsor, Simona; Aonofriesei, Florin; Iovu, Mircea, Medicinal Chemistry Research, 2012, 21(10), 3035-3042

合成路线：1 步

50-00-0

_92%

反应条件：

1.1 Solvents: Tetrahydrofuran ; 1 min, rt; rt → 120 °C; 6 min, 120 °C

参考文献：

Rapid synthesis of azole aminals under microwave heating conditions

Lupsor, Simona; Uivarosi, Valentina; Iovu, Mircea, Revista de Chimie (Bucharest, 2010, 61(3), 333-335

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Tetrabutylammonium bromide Solvents: Water ; overnight, reflux

参考文献：

Exploring different coordination modes of the first tetradentate NHC/1,2,3-triazole hybrid ligand for group 10 complexes

Schlagintweit, Jonas F.; Nguyen, Linda; Dyckhoff, Florian; Kaiser, Felix; Reich, Robert M.; et al, Dalton Transactions, 2019, 48(39), 14820-14828

合成路线：1 步

_83%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Acetonitrile ; 1.5 h, rt; rt → 60 °C; 5 h, 60 °C

参考文献：

Synthesis of bis(1-imidazolyl)methane

Cai, Juan; Zhao, Taotao; An, Gang; Zhou, Baoying; Hu, Quanyuan, Huaxue Yu Shengwu Gongcheng, 2009, 26(7), 22-24

合成路线：1 步

_82%

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Tetrabutylammonium bromide Solvents: Dichloromethane , Water ; 16 h, reflux

参考文献：

A highly stable but highly reactive zinc catalyst for transesterification supported by a bis(imidazole) ligand

Nakatake, Daiki; Yokote, Yuki; Matsushima, Yoshimasa; Yazaki, Ryo; Ohshima, Takashi, Green Chemistry, 2016, 18(6), 1524-1530

合成路线：1 步

_78%

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Tetrabutylammonium bromide Solvents: Dichloromethane , Water ; rt; 14 h, rt → 47 °C

参考文献：

Linear Pyrazole-bridged Tetra(N-heterocyclic carbene) Ligands and Their Hexanuclear Silver(I) Complexes

Resch, Stefan G.; Dechert, Sebastian; Meyer, Franc, Zeitschrift fuer Anorganische und Allgemeine Chemie, 2019, 645(6-7), 605-612

合成路线：1 步

_72%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Tetrabutylammonium bromide ; 1 h, rt
1.2 2 h, rt

参考文献：

Defined tetranuclear coinage metal chains

Kaub, Christoph; Lebedkin, Sergei; Bestgen, Sebastian; Koeppe, Ralf; Kappes, Manfred M.; et al, Chemical Communications (Cambridge, 2017, 53(69), 9578-9581

合成路线：1 步

_71%

反应条件：

1.1 Reagents: Sodium hydroxide , Tetrabutylammonium bromide Solvents: Water

参考文献：

Metallo-Cryptophanes Decorated with Bis-N-Heterocyclic Carbene Ligands: Self-Assembly and Guest Uptake into a Nonporous Crystalline Lattice

Henkelis, James J.; Carruthers, Christopher J.; Chambers, Scott E.; Clowes, Rob; Cooper, Andrew I.; et al, Journal of the American Chemical Society, 2014, 136(41), 14393-14396

合成路线：1 步

_70%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 0 °C; 48 h, 25 °C

参考文献：

Luminescence Sensing of Biomacromolecules Heparin and Protamine in 100% Human Serum and Plasma by Supramolecular Polymeric Assemblies

Biswas, Rakesh; Banerjee, Supratim, Biomacromolecules, 2023, 24(2), 766-774

合成路线：1 步

_66%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Tetrabutylammonium bromide Solvents: Water ; 15 min, rt
1.2 24 h, 25 °C

参考文献：

Syntheses of Symmetric and Unsymmetric Bis-imidazole Derivatives Using Phase-Transfer Catalysis

Zhang, Kun-Peng; Jin, Tian-Qi; Zhou, Jun-Qiang; Ma, Ting-Ting; Jin, Chuan-Ming, Journal of Heterocyclic Chemistry, 2017, 54(6), 3065-3070

合成路线：1 步

74-97-5

_64%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 3 h

参考文献：

Acetate-Selective Anion Receptor with Methylene-Bridged Bis-Imidazolium Rings

In, Sungjae; Kang, Jongmin, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2006, 54(1-2), 129-132

合成路线：1 步

74-97-5

_64%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 3 h, rt

参考文献：

Fluorescent anion receptor with two methylene bridged bis-imidazolium ring on anthracene

In, Sungjae; Kang, Jongmin, Bulletin of the Korean Chemical Society, 2005, 26(7), 1121-1124

合成路线：1 步

74-97-5

_64%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 3 h, rt

参考文献：

Iodide selective fluorescent anion receptor with two methylene bridged bis-imidazolium rings on naphthalene

Kim, Hyungil; Kang, Jongmin, Tetrahedron Letters, 2005, 46(33), 5443-5445

合成路线：1 步

_62%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Tetrabutylammonium bromide ; overnight, reflux

参考文献：

Nickel and Platinum PCP Pincer Complexes Incorporating an Acyclic Diaminoalkyl Central Moiety Connecting Imidazole or Pyrazole Rings

Puerta Lombardi, Braulio M.; Brown, Rudy M.; Gendy, Chris; Chang, Chia Yun; Chivers, Tristram; et al, Organometallics, 2017, 36(17), 3250-3256

合成路线：1 步

_60%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Tetrabutylammonium bromide ; 1 h, rt
1.2 rt; 5 h, rt

参考文献：

N-Heterocyclic Carbene-Iridium Complexes as Photosensitizers for In Vitro Photodynamic Therapy to Trigger Non-Apoptotic Cell Death in Cancer Cells

Wang, Xing; Zhang, Chen; Madji, Ryma; Voros, Camille; Mazeres, Serge; et al, Molecules, 2023, 28(2),

合成路线：1 步

_60%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Dichloromethane ; 12 h, 50 °C

参考文献：

Synthesis, crystal structures, in vitro anticancer, and in vivo acute oral toxicity studies of bis-imidazolium/benzimidazolium salts and respective dinuclear Ag(I)-N-heterocyclic carbene complexes

Haque, Rosenani A.; Hasanudin, Noorhafizah; Iqbal, Muhammad Adnan; Ahmad, Ashfaq; Hashim, Suzana; et al, Journal of Coordination Chemistry, 2013, 66(18), 3211-3228

合成路线：1 步

_60%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Tetrabutylammonium bromide ; 1 h, rt
1.2 2 h, rt

参考文献：

Dimeric Gold Bis(carbene) Complexes by Transmetalation in Water

Cure, Jeremy; Poteau, Romuald; Gerber, Iann C.; Gornitzka, Heinz; Hemmert, Catherine, Organometallics, 2012, 31(2), 619-626

合成路线：1 步